Patents by Inventor Liguo Chi

Liguo Chi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLE DERIVATIVES AS ANTI-PLATELET AND ANTI-THROMBOTIC AGENTS
    Publication number: 20080269293
    Abstract: This invention relates to novel compounds of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof wherein Y, R1 through R9, and X1 through X7 are as defined in the specification, pharmaceutical compositions containing said compounds useful as P2Y1 antagonists, and to methods of treating thromboembolic disorders.
    Type: Application
    Filed: August 22, 2007
    Publication date: October 30, 2008
    Inventors: Liguo Chi, Chulho Choi, Andrew G. Geyer, Robert M. Kennedy, Jeffery A. Pfefferkorn, Roy T. Winters
  • Method for direct measurement of coagulation factor VIIa activity in plasma
    Patent number: 6773896
    Abstract: The present invention generally provides a method of measuring the biological activity of Coagulation Factor VIIa (Factor VIIa). Specifically, the present invention provides a method for directly measuring the activity of Factor VIIa in a plasma sample. More specifically, the present invention provides a method for utilizing Factor VIIa activity as a bio-marker to monitor Factor VIIa inhibition to screen compounds which are able to inhibit the biological activity of Factor VIIa.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: August 10, 2004
    Assignee: Warner-Lambert Company
    Inventors: Liguo Chi, Robert Joseph Leadley, Jr., Yun-Wen Peng
  • Method for direct measurement of coagulation factor VIIa activity in plasma
    Publication number: 20020168700
    Abstract: The present invention generally provides a method of measuring the biological activity of Coagulation Factor VIIa (Factor VIIa). Specifically, the present invention provides a method for directly measuring the activity of Factor VIIa in a plasma sample. More specifically, the present invention provides a method for utilizing Factor VIIa activity as a bio-marker to monitor Factor VIIa inhibition to screen compounds which are able to inhibit the biological activity of Factor VIIa.
    Type: Application
    Filed: May 8, 2002
    Publication date: November 14, 2002
    Inventors: Liguo Chi, Robert Joseph Leadley, Jr., Yun-Wen Peng
  • Cardiovascular testing device
    Patent number: 5782759
    Abstract: The present invention relates to a method and device for creating and testing arterial and venous thrombotic conditions. The invention includes a tube which is inserted into a blood vessel of an animal. The tube contains one or more strands upon which various materials, such as procoagulants and anticoagulants may be placed. Blood flows through the tube and clots form on the threads. After the completion of the test, the tube is removed from the animal, the strands are removed from the tube and the clots may be measured and weighed. In a preferred embodiment, a flowmeter may be connected to the blood vessel to measure the blood flow so that the clot measurements may be correlated with the blood flow.
    Type: Grant
    Filed: December 30, 1996
    Date of Patent: July 21, 1998
    Assignee: Warner-Lambert Company
    Inventors: Liguo Chi, Lori Saganek, Kim P. Gallagher, Andrew Uprichard