Abstract: Methods, devices and apparatus for CT imaging in a CT system are provided. The CT system includes a CT console, a CT scanner and an image reconstruction computer. In one aspect, a method includes detecting, by the CT console, whether a parameter adjustment instruction is received from a user during a scanning process in which a preview image is generated and displayed to the user. If the parameter adjustment instruction is received, the CT console sends adjusted scan parameters to at least one of the CT scanner or the image reconstruction computer such that the CT scanner and the image reconstruction computer generate a new preview image based on the adjusted scan parameters that are determined according to the preview image. If the parameter adjustment instruction is not received, the CT console displays to the user a CT image generated by the image reconstruction computer after finishing the scanning process.

Abstract: Disclosed is a preparation method of phenoxycarboxylic acid herbicides. The preparation method comprises the following steps. S1: mixing an anhydrous phenol and a basic substance with a chloro-substituted carboxylic acid ester and performing a one-pot condensation reaction in an anhydrous system to obtain a phenoxycarboxylic acid ester. The chloro-substituted carboxylic acid ester is represented by the formula ClR1COOR, in which R1 is a C1-3 alkanediyl or alkylidene group, R is a C1-10 alkyl group or a C3-10 cycloalkyl group; S2: the phenoxycarboxylic acid ester undergoes selective chlorination with a chlorinating agent in the presence of a first catalyst and a second catalyst to obtain a chloro-substituted phenoxycarboxylic acid ester; and S3: the chloro-substituted phenoxycarboxylic acid ester undergoes an acid hydrolysis reaction to obtain a phenoxycarboxylic acid herbicide represented by formula I, in which R3 is H, Cl or CH3.

Abstract: Provided is a method for producing a chlorophenoxycarboxylate, comprising the following steps of: a phenoxycarboxylate under actions of a catalyst A and a catalyst B performing a selective chlorination of a chlorinating agent at a 2-position and/or a 4-position to obtain the chlorophenoxycarboxylate; the catalyst A is a Lewis acid; and the catalyst B has the following structure: R1?—S—R2?. The present disclosure redesigns the process route, and finely screens the catalyst and the chlorinating agent, thereby effectively improving the chlorination selectivity while avoiding the loss of the active ingredient, and the content of the obtained chlorophenoxycarboxylate can reach more than 98.5%, and the yield can reach more than 99%.

Abstract: Some embodiments of the invention include methods for treating an animal for disease or nerve damage, comprising administration of a composition comprising a myelination enhancing inhibitor to the animal. Other embodiments of the invention include methods for treating an animal for disease or nerve damage, comprising administration of a composition comprising an HDAC3 inhibitor to the animal. Still other embodiments of the invention include methods for treating an animal for MS or nerve damage, comprising administration of a composition comprising an HDAC3 inhibitor to the animal. Additional embodiments of the invention are also discussed herein.

Abstract: The present disclosure discloses monoclonal antibodies binding to type I interferon alpha receptor and their uses. The antibodies are capable of inhibiting the biological activity of type I interferons, and can be used for treating, preventing, or diagnosing the diseases mediated by the type I interferons. Also provided are immunoconjugate, bispecific molecule and pharmaceutical compositions comprising the antibodies of the present disclosure.

Abstract: Methods, devices and apparatus for CT imaging in a CT system are provided. The CT system includes a CT console, a CT scanner and an image reconstruction computer. In one aspect, a method includes detecting, by the CT console, whether a parameter adjustment instruction is received from a user during a scanning process in which a preview image is generated and displayed to the user. If the parameter adjustment instruction is received, the CT console sends adjusted scan parameters to at least one of the CT scanner or the image reconstruction computer such that the CT scanner and the image reconstruction computer generate a new preview image based on the adjusted scan parameters that are determined according to the preview image. If the parameter adjustment instruction is not received, the CT console displays to the user a CT image generated by the image reconstruction computer after finishing the scanning process.

Abstract: Provided herein is a recombinant non-human mammal having an immune system including human immune cells and having a liver including human liver cells, and methods for producing the same. Also provided are methods of screening a compound for activity in treating hepatitis, comprising: administering a test compound to a recombinant non-human mammal as described herein; and then detecting the presence or absence of said activity in said mammal (e.g., by biochemical assay), said presence of said activity in said mammal indicating that said compound has activity in treating hepatitis. Methods of making fusion cells useful for the production of human monoclonal antibodies are also provided.

Abstract: Provided herein is a recombinant non-human mammal having an immune system including human immune cells and having a liver including human liver cells, and methods for producing the same. Also provided are methods of screening a compound for activity in treating hepatitis, comprising: administering a test compound to a recombinant non-human mammal as described herein; and then detecting the presence or absence of said activity in said mammal (e.g., by biochemical assay), said presence of said activity in said mammal indicating that said compound has activity in treating hepatitis. Methods of making fusion cells useful for the production of human monoclonal antibodies are also provided.

Abstract: Provided herein is a recombinant non-human mammal having an immune system including human immune cells and having a liver including human liver cells, and methods for producing the same. Also provided are methods of screening a compound for activity in treating hepatitis, comprising: administering a test compound to a recombinant non-human mammal as described herein; and then detecting the presence or absence of said activity in said mammal (e.g., by biochemical assay), said presence of said activity in said mammal indicating that said compound has activity in treating hepatitis. Methods of making fusion cells useful for the production of human monoclonal antibodies are also provided.

Abstract: An ultrasonic imaging device, comprising: a receiver, for receiving ultrasonic signals which carry information about human body; a processor, for analyzing and processing the received ultrasonic signals in order to get image and/or sound signals; a controller, for issuing at least one instruction; and a recorder, for recording the image and/or sound signals on recording medium in digital form in accordance with the instruction.

Abstract: An ultrasonic imaging device, comprising: a receiver, for receiving ultrasonic signals which carry information about human body; a processor, for analyzing and processing the received ultrasonic signals in order to get image and/or sound signals; a controller, for issuing at least one instruction; and a recorder, for recording the image and/or sound signals on recording medium in digital form in accordance with the instruction.

Abstract: An ultrasonic imaging device, comprising: a receiver, for receiving ultrasonic signals which carry information about human body; a processor, for analyzing and processing the received ultrasonic signals in order to get image and/or sound signals; a controller, for issuing at least one instruction; and a recorder, for recording the image and/or sound signals on recording medium in digital form in accordance with the instruction.

Abstract: An ultrasonic imaging device, comprising: a receiver, for receiving ultrasonic signals which carry information about human body; a processor, for analyzing and processing the received ultrasonic signals in order to get image and/or sound signals; a controller, for issuing at least one instruction; and a recorder, for recording the image and/or sound signals on recording medium in digital form in accordance with the instruction.