Patents by Inventor Lih-Chu Chiou

Lih-Chu Chiou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIGANDS SELECTIVE TO ALPHA 6 SUBUNIT-CONTAINING GABAA RECEPTORS AND THEIR METHODS OF USE
    Publication number: 20210047322
    Abstract: Provided herein are novel pyrazoloquinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 18, 2021
    Inventors: Lih-Chu Chiou, James Cook, Margot Ernst, Pi-Chuan Fan, Daniel Knutson, Matheus Meirelles, Marko Mihovilovic, Werner Sieghart, Zdravko Varagic, Ranjit Verma, Laurin Wimmer, Christopher Witzigmann, David Chan Bodin Siebert, Miroslav M. Savic
  • Method for preparing hispidulin and its derivatives
    Patent number: 10532991
    Abstract: Provided is a method for preparing hispidulin or a derivative thereof. The method includes selective protection of trihydroxybenzaldehyde, followed by regioselective iodination, selective protection, Stille coupling, Baeyer-Villiger oxidation and basic hydrolysis to obtain a protected intermediate compound. Then, alkylation, Claisen-Schmidt condensation, cyclization and deprotection of the protected intermediate compound are performed to obtain hispidulin or the derivative thereof. The present disclosure provides an efficient method for total synthesis of hispidulin or the derivative thereof with concise reaction steps and high yield.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: January 14, 2020
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Wei-Jan Huang, Kai-Cheng Hsu, Lih-Chu Chiou, Liang-Chieh Chen, Hui-Ju Tseng, Pi-Chuan Fan
  • METHOD FOR PREPARING HISPIDULIN AND ITS DERIVATIVES
    Publication number: 20190322637
    Abstract: Provided is a method for preparing hispidulin or a derivative thereof. The method includes selective protection of trihydroxybenzaldehyde, followed by regioselective iodination, selective protection, Stille coupling, Baeyer-Villiger oxidation and basic hydrolysis to obtain a protected intermediate compound. Then, alkylation, Claisen-Schmidt condensation, cyclization and deprotection of the protected intermediate compound are performed to obtain hispidulin or the derivative thereof. The present disclosure provides an efficient method for total synthesis of hispidulin or the derivative thereof with concise reaction steps and high yield.
    Type: Application
    Filed: November 1, 2018
    Publication date: October 24, 2019
    Inventors: Wei-Jan Huang, Kai-Cheng Hsu, Lih-Chu Chiou, Liang-Chieh Chen, Hui-Ju Tseng, Pi-Chuan Fan
  • LIGANDS SELECTIVE TO ALPHA 6 SUBUNIT-CONTAINING GABAA RECEPTORS AND THEIR METHODS OF USE
    Publication number: 20180134698
    Abstract: Provided herein are novel pyrazolo-quinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis;depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.
    Type: Application
    Filed: June 3, 2016
    Publication date: May 17, 2018
    Inventors: Lih-Chu Chiou, James Cook, Margot Ernst, Pi-Chuan Fan, Daniel Knutson, Matheus Meirelles, Marko Mihovilovic, Werner Sieghart, Zdravko Varagic, Ranjit Verma, Laurin Wimmer, Christopher Witzigmann, David Chan Bodin Siebert, Miroslav M. Savic
  • Use of sp. for treating tic disorders or psychiatric disorders with sensorimotor gating deficits
    Patent number: 8182844
    Abstract: The present invention relates to the use of a composition made from Clerodendrum for treating tic disorder or sensorimotor gating deficits, wherein the composition is particularly made from the leaves of the plant.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: May 22, 2012
    Assignees: National Taiwan University, Taipei Medical University, Fu Jen Catholic University
    Inventors: Lih-Chu Chiou, Pi-Chuan Fan, Wei-Jan Huang, Su-Jane Wang
  • USE OF FLAVONES FOR TREATING PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS
    Publication number: 20120029066
    Abstract: Novel Use of flavones having 2-phenylchromen-4-one skeleton is disclosed herein. The flavones are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient diagnosed with a psychiatric disorder with sensorimotor gating deficits.
    Type: Application
    Filed: August 1, 2011
    Publication date: February 2, 2012
    Applicants: Taipei Medical University, National Taiwan University
    Inventors: Lih-Chu CHIOU, Wei-Jan HUANG
  • USE OF CLERODENDRUM SP. FOR TREATING TIC DISORDERS OR PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS
    Publication number: 20110159129
    Abstract: The present invention relates to the use of a composition made from Clerodendrum for treating tic disorder or sensorimotor gating deficits, wherein the composition is particularly made from the leaves of the plant.
    Type: Application
    Filed: June 30, 2010
    Publication date: June 30, 2011
    Applicants: NATIONAL TAIWAN UNIVERSITY, TAIPEI MEDICAL UNIVERSITY, FU JEN CATHOLIC UNIVERSITY
    Inventors: Lih-Chu Chiou, Pi-Chuan Fan, Wei-Jan Huang, Su-Jane Wang