Abstract: The present disclosure provides methods and devices for separation of motile sperm. A method of separating motile sperm comprises: introducing a fluid sample comprising motile sperm to an inlet portion of a microfluidic device; and causing the fluid sample to flow through a separation portion of the microfluidic device at a flow velocity within a rheotaxis range such that motile sperm in the sample undergo rheotaxis and remain in the separation whereas a part of the fluid sample flows out of the separation zone through an outlet portion of the microfluidic device.

Abstract: A fluid cartridge, comprising a channel layer within which at least one circumferentially sealed fluid channel is formed, the channel layer comprising a substrate and an elastic layer fixedly arranged on the substrate, wherein the substrate has a rigidity being greater than that of the elastic layer, and wherein the at least one fluid channel is defined on at least one side thereof by the elastic layer.

Abstract: A tunable MEMS filter is disclosed, having a substrate with first and second isolated substrate areas. First and second anchor points are coupled to the substrate. A base is coupled to the first and second anchor points by first and second coupling beams, respectively. A dielectric layer is coupled to the base. An input conductor is coupled to the at least one dielectric layer. An output conductor is coupled to the at least one dielectric layer. A method of tuning a center frequency and a bandwidth of a MEMS resonator filter is also disclosed. A first bias voltage is adjusted between a base layer and input and output conductor layers. A second bias voltage is adjusted between the base layer and isolated substrate areas. The center frequency and the bandwidth are determined until the adjustments to the bias voltages provide a desired center frequency and a desired bandwidth.

Abstract: A fluid cartridge, comprising a channel layer within which at least one circumferentially sealed fluid channel is formed, the channel layer comprising a substrate and an elastic layer fixedly arranged on the substrate, wherein the substrate has a rigidity being greater than that of the elastic layer, and wherein the at least one fluid channel is defined on at least one side thereof by the elastic layer.

Abstract: A tamable MEMS filter is disclosed, having a substrate with first and second isolated substrate areas. First and second anchor points are coupled to the substrate. A base is coupled to the first and second anchor points by first and second coupling beams, respectively. A dielectric layer is coupled to the base. An input conductor is coupled to the at least one dielectric layer. An output conductor is coupled to the at least one dielectric layer. A method of tuning a center frequency and a bandwidth of a MEMS resonator filter is also disclosed. A first bias voltage is adjusted between a base layer and input and output conductor layers. A second bias voltage is adjusted between the base layer and isolated substrate areas. The center frequency and the bandwidth are determined until the adjustments to the bias voltages provide a desired center frequency and a desired bandwidth.

Abstract: The present invention provides a device/kit and methods of use thereof in rapid detection of target molecule binding to a cognate binding partner. The methods, inter-alia, make use of a device comprising channels or reservoirs, which are linked to nanochannels, whereby upon application of the cognate binding partner to the nanochannel comprising the target molecule under flow, a detectable change in conductance, capacitance or fluorescence or surface potential occurs.