Abstract: The present invention relates to a cathepsin K inhibitor having the structure as shown in formula (0) and/or formula (II), wherein cyanopyrimidine or a keto group as an electrophilic group is a key group to exert a good inhibitory effect on cathepsin K. Further provided are a preparation method therefor and use thereof. The provided cathepsin K inhibitor has a relatively high inhibitory effect and selectivity, and is expected to be used for treating diseases including thyroid diseases, cardiovascular diseases, bone diseases and gum diseases.

Abstract: Systems and methods are disclosed for reducing a comet tail aberration in an image of an ablation catheter. In one example, the method includes receiving ICE images depicting the ablation catheter tip and an area proximate to the ablation catheter tip; automatically determining, by the computer system, a location of the tip of the ablation catheter in the received ICE images; automatically determining, by the computer system, the presence of a comet tail aberration in a region of interest (ROI) near the ablation catheter tip in the received ICE images; and in response to determining the aberration is present in the ROI, automatically changing, by the computer system, an imaging characteristic of the ICE imaging system to affect the appearance of the aberration in the ROI in subsequent images generated by the ICE imaging system using the changed imaging characteristic.

Abstract: A method for monitoring a target in a medical display in a medical imaging apparatus includes receiving echo signals from an area of interest of a patient, extracting raw data from the received echo signals, processing the extracted raw data to display a dual mode image on the medical display, and setting a location and displaying a first marker/cursor in a first image of the dual mode image. In addition, the method further includes determining a corresponding location of the marker/cursor in a second image of the dual mode image, and displaying a second marker/cursor in the second image of the dual mode image at the corresponding location simultaneously with the displaying of the first marker/cursor in the first image.

Abstract: A non-linear response may be measured by transmitting a first pulse at an amplitude and transmit frequency, using an aperture having N elements. A first response is measured at a sub-harmonic frequency based on the transmit frequency. At least second and third pulses are transmitted at the amplitude and transmit frequency. At least second and third responses are measured at the sub-harmonic frequency. The second and third pulses have the same phase with respect to each other and use first and second sub-apertures that have different ones of the N elements. A sum of the elements within the first and second sub-apertures is equal to N. Alternatively, at least two pulses having the same aperture and different amplitudes may be transmitted, and the responses measured at the sub-harmonic frequency. The responses are combined to suppress linear echoes and determine a non-linear response.

Abstract: Method and apparatus for automatically adjusting a parameter used in the display of a Doppler spectral image comprises acquiring a plurality of spectral lines of Doppler data. A subset of Doppler data is determined from the plurality of spectral lines of Doppler data. A noise characteristic of the subset of Doppler data is calculated, and a signal characteristic of the subset of Doppler data is identified. The noise and signal characteristics are compared, and a system parameter is adjusted based on a result of the comparing step.

Abstract: A method for measuring a non-linear response from a target using an imaging apparatus includes transmitting a signal towards a region of interest from a transducer at a first amplitude and measuring a first response thereto, and transmitting, from the transducer towards the region of interest, at least one additional signal of the same phase as the first amplitude signal but at one or more different, lower amplitudes and measuring at least one additional response thereto. A difference of a function of the measured additional response or responses from the first response is determined, thereby obtaining a non-linear response of the object of interest, and a representation of the non-linear response is displayed.

Abstract: Systems and methods for signal filtering are provided. A signal filter includes a linear regression filter component and a finite impulse response filter component. A received signal is first filtered by the linear regression filter component and then filtered by the finite impulse response filter component.

Abstract: A non-linear response may be measured by transmitting a first pulse at an amplitude and transmit frequency, using an aperture having N elements. A first response is measured at a sub-harmonic frequency based on the transmit frequency. At least second and third pulses are transmit at the amplitude and transmit frequency. At least second and third responses are measured at the sub-harmonic frequency. The second and third pulses have the same phase with respect to each other and use first and second sub-apertures that have different ones of the N elements. A sum of the elements within the first and second sub-apertures is equal to N. Alternatively, at least two pulses having the same aperture and different amplitudes may be transmit, and the responses measured at the sub-harmonic frequency. The responses are combined to suppress linear echoes and determine a non-linear response.

Abstract: A method for measuring a non-linear response from a target using an imaging apparatus includes transmitting a signal towards a region of interest from a transducer at a first amplitude and measuring a first response thereto, and transmitting, from the transducer towards the region of interest, at least one additional signal of the same phase as the first amplitude signal but at one or more different, lower amplitudes and measuring at least one additional response thereto. A difference of a function of the measured additional response or responses from the first response is determined, thereby obtaining a non-linear response of the object of interest, and a representation of the non-linear response is displayed.

Abstract: A method for monitoring a target in a medical display in a medical imaging apparatus includes receiving echo signals from an area of interest of a patient, extracting raw data from the received echo signals, processing the extracted raw data to display a dual mode image on the medical display, and setting a location and displaying a first marker/cursor in a first image of the dual mode image. In addition, the method further includes determining a corresponding location of the marker/cursor in a second image of the dual mode image, and displaying a second marker/cursor in the second image of the dual mode image at the corresponding location simultaneously with the displaying of the first marker/cursor in the first image.

Abstract: Contrast-enhancing agents enhance 3D and/or 4D ultrasound imagery, by which ultrasound machines acquire ultrasound image data and processors convert the ultrasound image data into contrast-enhanced 3D and/or 4D images using the contrast-enhancing agents. Various other embodiments may also include CTI processors, which can be adapted to generate CTI image data, and/or TIC processors, which can be adapted to generate TIC image data. Systems, methods, and computer-readable storage medium including a set of instructions for a computer are disclosed.

Abstract: Methods and systems for controlling an ultrasound system are provided. The method includes receiving scanning information from an ultrasound system, with the scanning information including at least one of image information and spectral information. The method further includes controlling power to a transducer of the ultrasound system based on the scanning information.

Abstract: Method and apparatus for automatically adjusting a parameter used in the display of a Doppler spectral image comprises acquiring a plurality of spectral lines of Doppler data. A subset of Doppler data is determined from the plurality of spectral lines of Doppler data. A noise characteristic of the subset of Doppler data is calculated, and a signal characteristic of the subset of Doppler data is identified. The noise and signal characteristics are compared, and a system parameter is adjusted based on a result of the comparing step.

Abstract: The present invention provides a method and system for using the computer keyboard and/or speech recognition technology to automatically fill an image annotation during an ultrasound scan. More specifically, it provides a method and a system for annotating a displayed ultrasound image using commands that is comprised of; providing an annotation vocabulary sorted in descending order of usage frequency providing a method to select a subset of words from the vocabulary that are relevant to the imaged anatomy, detecting the initial command, selecting a suggestion list from the selected sub-vocabulary, and displaying the suggestion list to the user for optional acceptance or further specification.

Abstract: A system for automatically adjusting color gain of an ultrasound image. Image data passes through a wall filter and is processed into a time-gain compensation curve. Values of the time-gain compensation curve are multiplied with corresponding image data values to compensate for attenuation of image data values with increasing depth in a patient. The values used to generate the time-gain compensation curve may be averaged to reduce localized gain variations and produce an image with smoother intensity transitions. To reduce the effect of a time-gain compensation curve on overall system gain, values of the time-gain compensation curve may be scaled to produce equalized values for the time-gain compensation curve. Values of the time-gain compensation curve may be used to adjust front end gain of an ultrasound system to bring the front end gain within a few decibels of noise floor.

Abstract: Systems and methods for signal filtering are provided. A signal filter includes a linear regression filter component and a finite impulse response filter component. A received signal is first filtered by the linear regression filter component and then filtered by the finite impulse response filter component.

Abstract: Methods and systems for controlling an ultrasound system are provided. The method includes receiving scanning information from an ultrasound system, with the scanning information including at least one of image information and spectral information. The method further includes controlling power to a transducer of the ultrasound system based on the scanning information.

Abstract: A system for automatically adjusting color gain of an ultrasound image. Image data passes through a wall filter and is processed into a time-gain compensation curve. Values of the time-gain compensation curve are multiplied with corresponding image data values to compensate for attenuation of image data values with increasing depth in a patient. The values used to generate the time-gain compensation curve may be averaged to reduce localized gain variations and produce an image with smoother intensity transitions. To reduce the effect of a time-gain compensation curve on overall system gain, values of the time-gain compensation curve may be scaled to produce equalized values for the time-gain compensation curve. Values of the time-gain compensation curve may be used to adjust front end gain of an ultrasound system to bring the front end gain within a few decibels of noise floor.

Abstract: The present invention provides a method and system for using the computer keyboard 12 and/or speech recognition technology to automatically fill an image annotation 32 during an ultrasound scan. More specifically, it provides a method and a system for annotating a displayed ultrasound image 30 using commands that is comprised of; providing an annotation vocabulary sorted in descending order of usage frequency providing a method to select a subset of words from the vocabulary that are relevant to the imaged anatomy, detecting the initial command, selecting a suggestion list from the selected sub-vocabulary, and displaying the suggestion list to the user for optional acceptance or further specification.