Patents by Inventor Lihong V. Wang

Lihong V. Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11137375
    Abstract: Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: October 5, 2021
    Assignee: California Institute of Technology
    Inventors: Lihong V. Wang, Lidai Wang, Chi Zhang, Puxiang Lai, Jian Wei Tay
  • Patent number: 11020006
    Abstract: Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: June 1, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Lihong V. Wang, Liming Nie, Xin Cai, Konstantin Maslov, Mark A. Anastasio, Chao Huang, Robert W. Schoonover
  • Publication number: 20160305914
    Abstract: Systems and methods for focusing a light pulse within a focus area using nonlinear photoacoustic wavefront shaping (PAWS) are disclosed herein. The method includes modulating a spatial phase pattern of a light pulse's waveform based on a Grueneisen-relaxation photoacoustic (GR-PA) feedback signal. In addition, systems and methods for performing Grueneisen-relaxation photoacoustic microscopy (GR-PAM) are disclosed herein that include analyzing photoacoustic signals resulting from illumination of a focus region by two closely spaced light pulses. A method of obtaining an absorption coefficient of a sample using Grueneisen-relaxation photoacoustic microscopy (GR-PAM) is also disclosed.
    Type: Application
    Filed: November 19, 2014
    Publication date: October 20, 2016
    Inventors: Lihong V. Wang, Lidai Wang, Chi Zhang, Puxiang Lai, Jian Wei Tay
  • Publication number: 20150245771
    Abstract: Systems and methods of reconstructing photoacoustic imaging data corresponding to a brain of a subject through a skull of a subject utilizing a reconstruction method that incorporates a spatial model of one or more acoustic properties of the brain and skull of the subject derived from an adjunct imaging dataset.
    Type: Application
    Filed: October 18, 2013
    Publication date: September 3, 2015
    Inventors: Lihong V. Wang, Liming Nie, Xin Cai, Konstantin Maslov, Mark A. Anastasio, Chao Huang, Robert W. Schoonover
  • Publication number: 20140142404
    Abstract: A single-RBC photoacoustic flowoxigraphy (FOG) device is described that delivers laser pulses of two different wavelengths separated by a pulse separation period of about 20 ?s. This separation period is sufficiently brief to enable pulses of two different wavelengths to illuminate the same single moving RBC. The acoustic signals elicited by the single RBC in response to the laser pulses of two different wavelengths may be analyzed using pulse oximetry methods similar to those described herein above to simultaneously determine a variety of functional parameters.
    Type: Application
    Filed: January 24, 2014
    Publication date: May 22, 2014
    Applicant: The Washington University
    Inventors: Lihong V. Wang, Konstantin Maslov, Lidai Wang