Abstract: This invention relates generally to segmented oligonucleotides capable of modulating gene expression. Specifically, the instant invention relates to segmented microRNA (miRNA) oligonucleotides, including segmented miRNA precursors and segmented pre-microRNAs. The invention also relates to compositions comprising such segmented oligonucleotides, as well as to methods of making and using such oligonucleotides for diagnosis and treatment of diseases associated or causally linked to aberrant levels or activities of gene expression, including aberrant levels of coding and/or non-coding RNA.

Abstract: Disclosed are a composite material, a shell for a mobile device, their manufacturing methods, and a mobile device. The composite material includes: a first metal substrate (100); a first resin fiber plate (200) disposed on an upper surface of the first metal substrate; an antenna layer (300) disposed on an upper surface of the first resin fiber plate; a second resin fiber plate (400) disposed on an upper surface of the antenna layer; and a second metal substrate (500) disposed on an upper surface of the second resin fiber plate.

Abstract: The present application relates to a garment steaming device (1). The garment steaming device comprises a housing (2) with a steam channel (8) arranged in the housing (2) for the passage of steam and a cavity extending into the housing (2). The garment steaming device (1) further comprises a fragrance cartridge (10) that is removeably disposed in the cavity and a valve assembly (11) which is disposed between the cavity and the steam channel (8). The valve assembly (11) is adapted to prevent steam to from flowing between the steam channel (8) and the cavity when the fragrance cartridge (10) is not disposed in the cavity. The valve assembly and the fragrance cartridge are adapted to cooperate such as to allow steam to flow between the steam channel and the cavity when the fragrance cartridge is disposed in the cavity. This solution allows a user to safely remove the fragrance cartridge from the cavity even when there is steam in the steam channel.

Abstract: Stain removal accessory (171) intended to cooperate with a stain removal device (1) for treating a stained area, the stain removal accessory (171) is attached to the front head of the stain removal device (1), namely to the water and/or steam venting face of said stain removal device (1), and comprises a container (400) like a pad, a cartridge, a sachet or a capsule provided with a permeable external layer, for containing a stain removing material (300), and a holder (600) for holding said container (400), whereby said stain removal accessory (171) is adapted to release said stain removing material (300) on the stained area when cooperating with the stain removal device (1) by facing the flow of water and/or steam (200) generated by said stain removal device (1).

Abstract: Portable stain removal kit (1) for locally removing a stained area on a fabric comprising a container (4) for containing a stain removing material (5) in a solid form, the container (4) being intended to be in direct contact with the stained area when the portable stain removal kit (1) is in use, whereby said portable stain removal kit (1) also comprises a base holder (3) for holding the container (4), and a cover (2) cooperating with the base holder (3) for enclosing the container (4) when the portable stain removal kit (1) is not in use.

Abstract: A metal-plastic composite and method for producing the same are provided. The metal-plastic composite comprises: a metal substrate and a plastic body jointed to the metal substrate via a dual-snap-fit structure, in which the dual-snap-fit structure comprises: a micro-snap-fit structure disposed on the metal substrate and a macro-snap-fit structure formed by the micro-snap-fit structure and a surface of the metal substrate.

Abstract: This invention relates generally to segmented oligonucleotides capable of modulating gene expression. Specifically, the instant invention relates to segmented microRNA (miRNA) oligonucleotides, including segmented miRNA precursors and segmented pre-microRNAs. The invention also relates to compositions comprising such segmented oligonucleotides, as well as to methods of making and using such oligonucleotides for diagnosis and treatment of diseases associated or causally linked to aberrant levels or activities of gene expression, including aberrant levels of coding and/or non-coding RNA.

Abstract: The instant disclosure features single-stranded RNA molecules comprising one or more internal, non-nucleotide spacers. A non-nucleotide spacer covalently links nucleotide portions of the molecule. The single-stranded RNA molecules function as guide or antisense strands that are capable of inhibiting gene expression via an RNA interference mechanism and, thus, represent single-stranded RNAi agents. The single-stranded RNAi molecules can be used in methods for a variety of therapeutic, diagnostic, target validation, genomic discovery, genetic engineering, and pharmacogenomic applications.

Abstract: The present application relates to a garment steaming device (1). The garment steaming device comprises a housing (2) with a steam channel (8) arranged in the housing (2) for the passage of steam and a cavity extending into the housing (2). The garment steaming device (1) further comprises a fragrance cartridge (10) that is removeably disposed in the cavity and a valve assembly (11) which is disposed between the cavity and the steam channel (8). The valve assembly (11) is adapted to prevent steam to from flowing between the steam channel (8) and the cavity when the fragrance cartridge (10) is not disposed in the cavity. The valve assembly and the fragrance cartridge are adapted to cooperate such as to allow steam to flow between the steam channel and the cavity when the fragrance cartridge is disposed in the cavity. This solution allows a user to safely remove the fragrance cartridge from the cavity even when there is steam in the steam channel.

Abstract: The present application relates to steam iron (1). The steam iron (1) comprises a sole plate (3). The sole plate (3) has a steam channel (6) for the passage of steam, an ironing surface (10), vents (4) for the passage of steam between the steam channel (6) and the ironing surface (10), an aperture (9) extending between the steam channel (6) and the ironing surface (10), and a fragrance cartridge (7) being received in the aperture (9) such that it extends into the steam channel (6) to diffuse fragrance in the steam channel (6). The aperture (9) secures the fragrance cartridge (10) in the sole plate (3) such that fragrance cartridge (7) is flush with the ironing surface (10). The present invention also relates to a fragrance cartridge (7) and to a method of imparting a fragrance to steam produced by a steam iron (1).

Abstract: The invention relates to a garment care device (D) comprising a chamber (C) to receive at least one garment (G). The garment care device (D) also comprises a heating system (HS) for heating the at least one garment (G). The garment care device (D) also comprises a lighting system (LS) for emitting inside the chamber (C), a radiation having wavelength in the range [280; 500] nm. The garment care device (D) also comprises a metal oxide photocatalyst element (MO) disposed inside the chamber (C) such that the metal oxide photocatalyst element (MO) can receive the radiation. The chamber (C) comprises receiving means to receive the at least one garment (G) such that the at least one garment (G) remains spaced from the metal oxide photocatalyst element (MO). The garment care device according to the invention allows the combination of drying and sanitizing of garments, while imparting pleasant smell to garment in a safe and eco-friendly way.

Abstract: Single-stranded RNA molecules comprise one or more internal, non-nucleotide spacers, covalently linked with nucleotide portions of the molecule are provided. The single-stranded RNA molecules function as guide or antisense strands that are capable of inhibiting gene expression via an RNA interference mechanism, and thus represent single-stranded RNAi agents. The single-stranded RNAi molecules can be used in methods for a variety of therapeutic, diagnostic, target validation, genomic discovery, genetic engineering, and pharmacogenomic applications.

Abstract: Disclosed are a composite material, a shell for a mobile device, their manufacturing methods, and a mobile device. The composite material includes: a first metal substrate (100); a first resin fibre plate (200) disposed on an upper surface of the first metal substrate; an antenna layer (300) disposed on an upper surface of the first resin fibre plate; a second resin fibre plate (400) disposed on an upper surface of the antenna layer; and a second metal substrate (500) disposed on an upper surface of the second resin fibre plate.

Abstract: The present application relates to steam iron (1). The steam iron (1) comprises a sole plate (3). The sole plate (3) has a steam channel (6) for the passage of steam, an ironing surface (10), vents (4) for the passage of steam between the steam channel (6) and the ironing surface (10), an aperture (9) extending between the steam channel (6) and the ironing surface (10), and a fragrance cartridge (7) being received in the aperture (9) such that it extends into the steam channel (6) to diffuse fragrance in the steam channel (6). The aperture (9) secures the fragrance cartridge (10) in the sole plate (3) such that fragrance cartridge (7) is flush with the ironing surface (10). The present invention also relates to a fragrance cartridge (7) and to a method of imparting a fragrance to steam produced by a steam iron (1).

Abstract: The invention relates to a treatment plate (10) for a garment treatment appliance (100) for treating garments (30), which plate has a contact surface which is provided with a sol-gel coating (20) that comprises an oxide of titanium, zirconium, hafnium, scandium, yttrium, or a mixture or combination thereof. The layer preferably has a thickness of less than 1 ?m. Such a layer shows excellent properties. A garment treatment appliance comprising such a treatment plate, as well as processes to produce the coating on the contact surface of the treatment plate are also disclosed.

Abstract: This invention relates generally to segmented oligonucleotides capable of modulating gene expression. Specifically, the instant invention relates to segmented microRNA (miRNA) oligonucleotides, including segmented miRNA precursors and segmented pre-microRNAs. The invention also relates to compositions comprising such segmented oligonucleotides, as well as to methods of making and using such oligonucleotides for diagnosis and treatment of diseases associated or causally linked to aberrant levels or activities of gene expression, including aberrant levels of coding and/or non-coding RNA.

Abstract: A metal-plastic composite and method for producing the same are provided. The metal-plastic composite comprises: a metal substrate and a plastic body jointed to the metal substrate via a dual-snap-fit structure, in which the dual-snap-fit structure comprises: a micro-snap-fit structure disposed on the metal substrate and a macro-snap-fit structure formed by the micro-snap-fit structure and a surface of the metal substrate.

Abstract: Single-stranded RNA molecules comprise one or more internal, non-nucleotide spacers, covalently linked with nucleotide portions of the molecule are provided. The single-stranded RNA molecules function as guide or antisense strands that are capable of inhibiting gene expression via an RNA interference mechanism, and thus represent single-stranded RNAi agents. The single-stranded RNAi molecules can be used in methods for a variety of therapeutic, diagnostic, target validation, genomic discovery, genetic engineering, and pharmacogenomic applications.

Abstract: Single-stranded RNA molecules comprise one or more internal, non-nucleotide spacers, covalently linked with nucleotide portions of the molecule are provided. The single-stranded RNA molecules function as guide or antisense strands that are capable of inhibiting gene expression via an RNA interference mechanism, and thus represent single-stranded RNAi agents. The single-stranded RNAi molecules can be used in methods for a variety of therapeutic, diagnostic, target validation, genomic discovery, genetic engineering, and pharmacogenomic applications.

Abstract: The invention relates to a treatment plate (10) for a garment treatment appliance (100) for treating garments (30), which plate has a contact surface which is provided with a sol-gel coating (20) that comprises an oxide of titanium, zirconium, hafnium, scandium, yttrium, or a mixture or combination thereof. The layer preferably has a thickness of less than 1 ?m. Such a layer shows excellent properties. A garment treatment appliance comprising such a treatment plate, as well as processes to produce the coating on the contact surface of the treatment plate are also disclosed.