Patents by Inventor Lihren Chen

Lihren Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dihydrodipyrazolopyridinone inhibitors of B7-1
    Publication number: 20040044024
    Abstract: The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection, autoimmune disease or graft vs. host disease.
    Type: Application
    Filed: July 28, 2003
    Publication date: March 4, 2004
    Applicant: Wyeth
    Inventors: Neal Jeffrey Green, Steve Yikkai Tam, Jason Shaoyun Xiang, Audrey Molina Davies, Lihren Chen, Gary Paul Stack
  • Dihydropyrazolo[3,4-d]thieno-[2,3-B]pyridinone inhibitors of B7-1
    Publication number: 20040024009
    Abstract: The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection, autoimmune disease or graft vs. host disease.
    Type: Application
    Filed: July 28, 2003
    Publication date: February 5, 2004
    Applicant: Wyeth
    Inventors: Neal Jeffrey Green, Lihren Chen, Steve Yikkai Tam
  • Dihydrodipyrazolopyridinylbenzamide and -sulfonamide inhibitors of B7-1
    Publication number: 20040024008
    Abstract: The present invention provides a compound of formula I and the use thereof for the immunotherapeutic treatment of transplant rejection or autoimmune disease.
    Type: Application
    Filed: July 28, 2003
    Publication date: February 5, 2004
    Applicant: Wyeth
    Inventors: Neal Jeffrey Green, Jason Shaoyun Xiang, Audrey Molina Davies, Lihren Chen
  • N-benzhydryl indole compounds
    Patent number: 6635771
    Abstract: Compounds of the formula in which R, R′, R7-R11, X, n1 and n3 are as defined herein. These compounds are useful as intermediates for preparing pharmaceutical compounds having pharmacological activity as chemical inhibitors of the activity of various phospholipase enzymes, particularly phospholipase A2 enzymes.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: October 21, 2003
    Assignee: Wyeth
    Inventors: John C. McKew, Steven Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Inhibitors of phospholipase enzymes
    Patent number: 6630496
    Abstract: This invention provides substituted indole and indoline compounds useful in inhibiting phospholipase activity, particularly including cytosolic phospholipase A2 (cPLA2) activity, as well as pharmaceutical compositions containing the compounds and methods of using them to treat various maladies, including pain and inflammatory conditions.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: October 7, 2003
    Assignee: Genetics Institute LLC
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Jean E. Bemis, YiBin Xiang, Lihren Chen
  • Methods for treating arthritic disorders
    Publication number: 20030166649
    Abstract: This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: September 4, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • N-BENZHYDRYL INDOLE COMPOUNDS
    Publication number: 20030158405
    Abstract: Compounds of the formula 1
    Type: Application
    Filed: November 22, 2002
    Publication date: August 21, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Methods for treating asthmatic conditions
    Publication number: 20030149029
    Abstract: This invention provides methods for treating in mammals asthma and asthmatic conditions using substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: August 7, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Inhibitors of cytosolic phospholipase A2
    Publication number: 20030144282
    Abstract: This invention provides substituted indole compounds of the general formula: 1
    Type: Application
    Filed: November 22, 2002
    Publication date: July 31, 2003
    Applicant: Wyeth
    Inventors: John C. McKew, Steve Y. Tam, Katherine L. Lee, Lihren Chen, Paresh Thakker, Fuk-Wah Sum, Mark Behnke, Baihua Hu, James D. Clark
  • Inhibitors of phospholipase enzymes
    Patent number: 6500853
    Abstract: This invention concerns compounds and pharmaceutical compositions useful for treating or preventing inflammatory conditions in a mammal, the methods comprising administration of novel pharmaceutically useful compounds of the general formulae: or pharmaceutically acceptable salts thereof, wherein R1-R5 are as defined in the specification.
    Type: Grant
    Filed: October 11, 2000
    Date of Patent: December 31, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang, Lihren Chen, John L. Knopf
  • Omega-deoxy-azasugars
    Patent number: 5596005
    Abstract: Omega-deoxy-azapyranose compounds, processes of making and using the same are disclosed, as are a process of making omega-deoxy-azafuranose compounds.
    Type: Grant
    Filed: December 23, 1993
    Date of Patent: January 21, 1997
    Assignee: The Scripps Research Institute
    Inventors: Chi-Huey Wong, Tetsuya Kajimoto, Kun-Chin Liu, Lihren Chen
  • Process for forming omega-deuxy-azasugars
    Patent number: 5276120
    Abstract: A process for the preparation of a 1,5-dideoxyazafuranose or 1,6-dideoxy-azapyranose is disclosed. In such a process, an azido-substituted .alpha.-ketose phosphate having a five- or a six-carbon chain is hydrogenated in the presence of a palladium catalyst. The carbon atom bearing the azido substituent and the carbon atom of the keto group of the .alpha.-ketose phosphate starting material are separated by two or three carbon atoms.
    Type: Grant
    Filed: February 13, 1992
    Date of Patent: January 4, 1994
    Assignee: The Scripps Research Institute
    Inventors: Chi-Huey Wong, Tetsuya Kajimoto, Kun-Chin Liu, Lihren Chen