Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: The present invention provides a method for preparing an additive-free cell-wall-broken granule of a Chinese medicinal material. The cell-wall-broken granule is obtained by medicinal material concocting and grinding, first cell-wall-breaking and grinding, screening, second wall-breaking and grinding, mixing, pelleting, and granulating and sieving. The obtained granule has a moderate tightness, a relatively rapid dissolution and diffusion and a good uniformity, overcoming problems of a difficulty of dissolution and diffusion and a poor uniformity of the existing cell-wall-broken granules.

Abstract: The present invention provides a method for preparing an additive-free cell-wall-broken granule of a Chinese medicinal material. The cell-wall-broken granule is obtained by medicinal material concocting and grinding, first cell-wall-breaking and grinding, screening, second wall-breaking and grinding, mixing, pelleting, and granulating and sieving. The obtained granule has a moderate tightness, a relatively rapid dissolution and diffusion and a good uniformity, overcoming problems of a difficulty of dissolution and diffusion and a poor uniformity of the existing cell-wall-broken granules.

Abstract: The present application provides a rubber spring, including a first mounting plate and a second mounting plate, the first mounting plate having a first V-shaped plate with an opening angle larger than 90°, and the second mounting plate having a second V-shaped plate with an opening angle larger than 90°; and a plurality of rubber layers arranged between the first V-shaped plate and the second V-shaped plate, wherein each two adjacent rubber layers are separated by an intermediate plate, the intermediate plate is a V-shaped plate with an opening angle larger than 90°, and openings of the first V-shaped plate, the second mounting plate and the intermediate plate are facing the same direction. The present application further provides a rubber suspension system and a truck.