Abstract: The present application discloses a primer set, a reagent, a kit for detecting methylation of a specific region of a human colorectal cancer-related gene from feces, blood, or tissue by using specific PCR, and the application thereof. The primer set includes specific amplified primer probe sequences for the methylated regions of specific regions of the gene markers PRDM12, FOXE1, and B3GAT2 genes found in this study; and the primer probe group also includes the specific amplification primer probe sequence of the methylated region of the specific region of the Vimentin, SFRP2-1, and SFRP2-2 genes and the specific amplification primer probe group of the internal reference gene ACTB, thus having high detection efficiency and strong pertinence.

Abstract: A method for preparing an SCR catalyst may include: (1) placing a first aqueous solution containing a titanium oxide and a tungstate in an electric field environment, adjusting the pH value of the first aqueous solution, and adjusting the current direction of the electric field environment to obtain a first mixture; (2) providing a second mixture by, in the electric field environment, adding dropwise a second aqueous solution containing a soluble salt of one or more active components, a copper-organic polyamine complex and a dispersant to the first mixture, and adjusting the current direction; and (3) processing the second mixture to obtain the SCR catalyst. The one or more active components may be selected from Ce, Zr, Cu, Fe, Pr and Sc.

Abstract: The present disclosure discloses an inhibitor for abnormal lipid metabolism of tumor cells with a plant cyclopeptide as an effective component, and discloses application of the inhibitor to preparation of drugs for inhibiting abnormal lipid metabolism of the tumor cells, which specifically can be applied to preparation of drugs for treating and preventing abnormal lipid metabolism related cancers including liver cancer, colon cancer, rectal cancer and prostatic cancer. The inhibitor for abnormal lipid metabolism of the cells of the present disclosure can effectively inhibit abnormal lipid metabolism of the tumor cells. Its effective component, the plant cyclopeptide, is wide in source and mature in extraction technology. The inhibitor has diversified dosage forms and medication ways and has a wide clinical application prospect.

Abstract: A cell autophagy inhibitor using a rubiaceae-type cyclopeptide as the active ingredient, and is particularly used for inhibiting KRAS mutation, especially protective autophagy of KRAS dependent tumor cells, and promoting tumor cell apoptosis; the inhibitor is preferably a nano-micelle injection, which can be used to the preparation of a medicament for treating and preventing KRAS-related cancers including colon cancer, rectal cancer, lung cancer and pancreatic cancer. The cell autophagy inhibitor of the present invention can effectively inhibit the protective autophagy of tumor cells, and its active ingredient rubiaceae-type cyclopeptides have a wide range of sources, mature extraction processes, diversified dosage forms and administration methods, and can be used to the treatment and prevention of KRAS-related cancers and have broad clinical application prospects.

Abstract: The disclosure relates to application of a compositae type cyclopeptide compound or a pharmacologically permissible salt as a cGAS-STING signal channel inhibitor and application of the compositae type cyclopeptide compound or the pharmacologically permissible salt as the cGAS-STING signal channel inhibitor in preparing a drug for treating diseases caused by abnormal activation of a cGAS-STING signal channel. As the compositae type cyclopeptide compound is a natural compound diversified in dosage form and medication mode, the compositae type cyclopeptide compound has a wide clinical application prospect.

Abstract: A variable geometry turbine having a wastegate includes a turbine housing, a power turbine, and a regulating valve. The turbine housing is provided with an inner intake gas flow channel and an outer intake gas flow channel. The turbine housing is further provided with a wastegate pipeline configured to bypass the power turbine, and a wastegate valve configured to control communication of the wastegate pipeline. One of the regulating valve and the wastegate valve has a regulating face having a varying axial height in a rotation direction of the regulating valve, and the other of the regulating valve and the wastegate valve has a linking portion which makes contact and cooperates with the regulating face. Thus, the efficiency of the turbine is improved significantly and backflow of the gas flow is reduced.

Abstract: A method for preparing an SCR catalyst may include: (1) placing a first aqueous solution containing a titanium oxide and a tungstate in an electric field environment, adjusting the pH value of the first aqueous solution, and adjusting the current direction of the electric field environment to obtain a first mixture; (2) providing a second mixture by, in the electric field environment, adding dropwise a second aqueous solution containing a soluble salt of one or more active components, a copper-organic polyamine complex and a dispersant to the first mixture, and adjusting the current direction; and (3) processing the second mixture to obtain the SCR catalyst. The one or more active components may be selected from Ce, Zr, Cu, Fe, Pr and Sc.

Abstract: A variable geometry turbine having a wastegate, which meets the requirements of EGR circulation, includes a turbine housing and a power turbine. The turbine housing is provided with an inner intake gas flow channel and an outer intake gas flow channel which is configured to guide exhaust gas of an engine to the power turbine for driving the power turbine to rotate. The turbine housing is further provided with a wastegate pipeline configured to discharge the exhaust gas without passing through the power turbine, and a wastegate valve configured to control communication and cutting off of the wastegate pipeline, and in the case that an intake gas amount of the exhaust gas entering into the turbine exceeds a preset value, the wastegate valve is opened to discharge a part of the exhaust gas via the wastegate pipeline.

Abstract: A centrifugal compressor, including: a housing, the housing including: an inlet, a flow channel, an impeller outlet, and an air diffusing channel; a centrifugal impeller disposed inside the housing; a rotating wall, the rotating wall including a front cascade; and a rotating disc, the rotating disc including a rear cascade. The impeller outlet is disposed adjacent to a rear part of the centrifugal impeller and is connected to the flow channel via the air diffusing channel. The rotating wall is disposed between the centrifugal impeller and the housing. The front cascade is disposed inside the front part of the rotating wall and is connected to a dynamic driving device. The rotating disc is disposed inside the housing adjacent to the air diffusing channel and is in a rigid connection with the rotating wall.

Abstract: A turbine device, including: a turbine housing including an inlet, a flow channel, an outlet, a middle partition, an arced partition; a turbine impeller; a gas outlet; and an exhaust manifold. The turbine impeller and the gas outlet are arranged inside the turbine housing. The exhaust manifold is connected to the inlet. The flow channel is arranged inside the turbine housing. The outlet is arranged on the flow channel close to the turbine impeller. The middle partition is disposed inside the flow channel and divides the flow channel into a left flow channel and a right flow channel. The arced partition is arranged in both the left and right flow channels. One end of the arced partition is in a rigid connection with the middle partition, and the other end of the arced partition is close to the outlet of the turbine housing.

Abstract: A compressor of a turbocharger including a compressor housing and a compressor impeller. The compressor housing includes: a compressor flow passage, a compressor air inlet, and a compressor air outlet. The compressor impeller includes an impeller feeding flow passage. The compressor impeller is disposed inside the compressor housing. The compressor flow passage is disposed inside the compressor housing. The compressor flow passage is connected to the compressor air inlet and the compressor air outlet. The impeller air feeding flow passage is connected to the compressor air inlet and the compressor flow passage.

Abstract: A volute, including: an intake passage, a diffuser channel, an air inlet communicating with the intake passage, an air outlet communicating with the diffuser channel, a left pneumatic baffle, a right pneumatic baffle, and intake regulating devices. The left pneumatic baffle and the right pneumatic baffle are disposed in the intake passage to divide the intake passage into a left outer passage, an inner passage, and a right outer passage. The intake regulating devices are disposed in the left outer passage and in the right outer passage, in the proximity of the air inlet.