Abstract: A nasogastic device and method is provided, including a first flexible tube having a distal end configured to be threaded through the nose of a patient, down the esophagus and into the stomach for enteral feeding, a second flexible tube disposed adjacent to the first tube having a distal end proximate to the distal end of the first flexible tube, the distal end of the second tube configured to terminate inside the esophagus for delivery of liquids to the esophagus or for sampling of the local environment, an inflatable balloon configured around the first and second flexible tubes, the inflatable balloon disposed proximal to the distal end of the first and second flexible tubes, a third flexible tube in fluid communication with the balloon configured to inflate the inflatable balloon; and a fourth flexible tube having a distal end portion communicating with an exterior portion of the inflatable balloon, the fourth tube configured to transport suspensions or solutions of materials, such as therapeutic molecules

Abstract: A nasogastric device and method is provided, including a first flexible tube configured to be threaded through the nose of a patient, down the esophagus and into the stomach for enteral feeding, a second flexible tube disposed adjacent to the first tube having a distal end, the distal end of said second tube configured to terminate inside the esophagus for delivery of liquids to the esophagus or for sampling of the local environment, an inflatable balloon configured around said first and second flexible tubes, a third flexible tube configured to inflate said inflatable balloon; and a fourth flexible tube communicating with an exterior portion of said inflatable balloon, the fourth tube configured to transport suspensions or solutions of materials; and an elastomeric sleeve which is used to control delivery of therapeutic suspensions of solutions of materials to the exterior of the device to the adjacent esophageal tissue.

Abstract: A nasogastric device and method is provided, including a first flexible tube configured to be threaded through the nose of a patient, down the esophagus and into the stomach for enteral feeding, a second flexible tube disposed adjacent to the first tube having a distal end, the distal end of said second tube configured to terminate inside the esophagus for delivery of liquids to the esophagus or for sampling of the local environment, an inflatable balloon configured around said first and second flexible tubes, a third flexible tube configured to inflate said inflatable balloon; and a fourth flexible tube communicating with an exterior portion of said inflatable balloon, the fourth tube configured to transport suspensions or solutions of materials; and an elastomeric sleeve which is used to control delivery of therapeutic suspensions of solutions of materials to the exterior of the device to the adjacent esophageal tissue.

Abstract: Calcium phosphate nanoparticle active agent conjugates are described. Specifically, anticancer agent conjugates are prepared which are suitable for targeted active agent delivery to tumor cells and lymphatics for the treatment of cancer and the treatment or prevention of cancer metastasis.

Abstract: Calcium phosphate nanoparticle active agent conjugates are described. Specifically, anticancer agent conjugates are prepared which are suitable for targeted active agent delivery to tumor cells and lymphatics for the treatment of cancer and the treatment or prevention of cancer metastasis.