Abstract: Disclosed relates to a method for skinning technology based on extended PBD and for weight retargeting in character animation. A corresponding tetrahedral mesh is generated for a given triangular mesh; a tensile constraint, a volume constraint, a self-collision constraint and an energy constraint of the extended PBD are initialized for the tetrahedral mesh, and vertex weights of the triangular mesh and the tetrahedral mesh are optimized simultaneously; the deformations of the triangular and the tetrahedral meshes are implemented through LBS technique; deformation results of the LBS are optimized through extended PBD; the joint region of the triangular mesh is smoothed through a Laplacian smoothing; bi-harmonic distance fields of the original mesh and a new mesh are calculated respectively, and two corresponding vertices of the mesh are given and a prediction function is defined; A weight retargeting algorithm is implemented in the present application and has a good practicability.

Abstract: The present invention relates to the field of the chemical medicines, and in particular, to purinyl-N-hydroxyl pyrimidine formamide derivatives, a preparation method therefor and a use thereof. The present invention provides a purinyl-N-hydroxyl pyrimidine formamide derivative having a structure represented by formula (I). The invention also provides a method for preparing said purinyl-N-hydroxyl pyrimidine formamide derivative and a use thereof. Purinyl-N-hydroxyl pyrimidine formamide derivative provided in the invention can be not only a PI3K and HDAC double-functional target kinase inhibitor, but also a PI3K or HDAC single target kinase inhibitor, thus providing new choice for preparing multi-target inhibitors.

Abstract: The invention discloses a crystal form A of a compound (I) and a preparation method thereof, and further discloses an application of the crystal form A as a PDE2 or TNF-? inhibitor.

Abstract: The present invention pertains to the field of chemical medicine, particularly to 4-substituted coumarin derivatives and preparation methods and applications thereof. The invention provides 4-substituted coumarin derivatives with a structural formula as shown in Formula I. The invention also provides preparation methods and applications for the above 4-substituted coumarin derivatives. The compounds provided in the invention have strong anti-tumor activity with IC50 for plural tumor cell lines between 0.01-5 nM, and it also performs better to inhibit microtubule polymerization and has diversified biological activities and low toxicity, providing new options for drug-sensitive and drug-resistant tumor cells.

Abstract: Disclosed relates to a method for skinning technology based on extended PBD and for weight retargeting in character animation. A corresponding tetrahedral mesh is generated for a given triangular mesh; a tensile constraint, a volume constraint, a self-collision constraint and an energy constraint of the extended PBD are initialized for the tetrahedral mesh, and vertex weights of the triangular mesh and the tetrahedral mesh are optimized simultaneously; the deformations of the triangular and the tetrahedral meshes are implemented through LBS technique; deformation results of the LBS are optimized through extended PBD; the joint region of the triangular mesh is smoothed through a Laplacian smoothing; bi-harmonic distance fields of the original mesh and a new mesh are calculated respectively, and two corresponding vertices of the mesh are given and a prediction function is defined; A weight retargeting algorithm is implemented in the present application and has a good practicability.

Abstract: The present invention relates to the field of the chemical medicines, and in particular, to purinyl-N-hydroxyl pyrimidine formamide derivatives, a preparation method therefor and a use thereof. The present invention provides a purinyl-N-hydroxyl pyrimidine formamide derivative having a structure represented by formula (I). The invention also provides a method for preparing said purinyl-N-hydroxyl pyrimidine formamide derivative and a use thereof. Purinyl-N-hydroxyl pyrimidine formamide derivative provided in the invention can be not only a PI3K and HDAC double-functional target kinase inhibitor, but also a PI3K or HDAC single target kinase inhibitor, thus providing new choice for preparing multi-target inhibitors.

Abstract: A compound represented by Formula I or pharmaceutically acceptable salt thereof. The present invention relates to a 4-arylamino quinazoline hydroxamic acid compound having a histone deacetylase inhibitory activity, preparation method of the compound, pharmaceutical composition comprising the compound, and use of the compound and the pharmaceutical composition in the preparation of a histone deacetylase inhibitor medicine. The present invention aims at acquiring, via a medicine design and a synthetic technology, a series of selective histone deacetylase inhibitors having good hypotype selectivity and favorable pharmacokinetic characteristics based on optimization of an enzyme surface recognition region and connection region of 4-arylamino quinazoline, thus reducing an effect on normal tissues or cells while improving an antineoplastic activity of the normal tissues or cells.

Abstract: Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

Abstract: The present application provides audio file acquisition and update notification sending methods, devices, and systems. One audio file acquisition method disclosed herein includes: receiving an audio file update notification by an audio playing device; prompting update by the audio playing device in response to the audio file update notification; receiving an audio file acquisition instruction by the audio playing device; and acquiring an updated audio file by the audio playing device in response to the audio file acquisition instruction. The present application further discloses audio playing devices. Embodiments of the present disclosure can help improve audio file acquisition efficiency and reduce resource consumption.

Abstract: Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

Abstract: The present invention relates to millepachine ((E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one) and its analogs. The present invention provides methods for preparing these compounds, pharmaceutical compositions including these compounds, and methods of treating diseases utilizing pharmaceutical compositions including these compounds.

Abstract: The present invention relates to millepachine ((E)-1-(5-methoxy-2,2-dimethyl-2H-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one) and its analogues. The present invention provides methods for preparing these compounds, pharmaceutical compositions including these compounds, and methods of treating diseases utilizing pharmaceutical compositions including these compounds.

Abstract: Interactive resource competition ranks resource users using coefficients of performance (CoP). Resource users compete for a target resource and each offer a quantifiable reciprocal resource in exchange for using the target resource. A trigger frequency of a predetermined action with respect to the target resource is recorded, and the CoP based on the respective reciprocal resource value and the trigger frequency is determined. The target resource is then allocated based on the ranking of the CoP's. An intermediate and credit fund account is used for both making payments and recording the trigger frequency. The competition is particularly useful for allocating an information display position in online electronic marketing.