Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Disclosed are novel compounds of Formula I that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: Provided is a pixel circuit. The pixel circuit includes a data writing circuit, a light-emission adjusting circuit, a light-emission control circuit, and a light-emission driving circuit; wherein the data writing circuit is coupled to a gate signal terminal, a first data signal terminal and a first node; the light-emission adjusting circuit is coupled to a target signal terminal, the first node and a second node; the light-emission control circuit is coupled to the second node, a reference signal terminal, a light-emission control signal terminal and a third node; the light-emission driving circuit is coupled to the third node, the gate signal terminal, a first power supply terminal, a second data signal terminal and a light-emitting element.

Abstract: Processing a network configuration file is described. An example method includes acquiring a network configuration file of a first cluster system, the network configuration file including an original Internet protocol address and acquiring an address translation rule set by a user, the address translation rule including a rule for translating one address of an original network address and an original host address that form the original Internet protocol address. The method further includes acquiring a target Internet protocol address by translating the one address in the original Internet protocol address based on the address translation rule. The method further includes storing the network configuration file including the target Internet protocol address in a second cluster system.

Abstract: A display substrate and a display device are provided. The display substrate includes light emitting diode chips, each light emitting diode chip includes light emitting units which respectively emit light of different colors, each light emitting unit includes a first electrode, a light emitting layer, a base and a second electrode, and the base and the second electrode are respectively located at both sides of the light emitting layer. In each light emitting diode chip, the light emitting units share the base and the first electrode, the light emitting layers of the light emitting units emit light of the same color, and at least one light emitting unit further includes a first color conversion layer located at a side of the base away from the light emitting layer, so as to convert first color light emitted by the light emitting layer into second color light.

Abstract: An atomization core is provided in an atomization channel and configured to heat an atomization substrate. The atomization core includes a first heating member, a second heating member, an electrode portion and a controller. The first heating member and the second heating member are disposed in the atomization channel, the first heating member is disposed near an outlet of the atomization channel, and the second heating member is disposed near an atomization substrate outlet of the atomization channel. The controller is connected to each of the first heating member and the second heating member through the electrode portion to control an operation of the first heating member and/or an operation of the second heating member.

Abstract: Disclosed is a method for determining a reasonable soaking time of a shale oil/gas well, implementing testing and experimentation using a device for testing a reasonable soaking time of a shale oil/gas well.

Abstract: The present invention discloses systems and methods for supplying hot water for primary extraction in the oil sands bitumen extraction process. Direct contact process and method for producing hot water using mature fine tailings are provided by employing a double staged submerge arrangement with a thickener vessel containing a submerged fuel burner and a hot water vessel containing a submerged fuel burner, a flash submerged arrangement with a flash concentrator vessel containing or adjacent to a fuel burner and a hot water vessel containing a submerged fuel burner or a triple cascade arrangement with a flash concentrator vessel, a thickener vessel containing a submerged fuel burner and a hot water vessel containing a submerged fuel burner.

Abstract: An oscillator includes a resonator, sustaining circuit and detector circuit. The sustaining circuit receives a sense signal indicative of mechanically resonant motion of the resonator generates an amplified output signal in response. The detector circuit asserts, at a predetermined phase of the amplified output signal, one or more control signals that enable an offset-reducing operation with respect to the sustaining amplifier circuit.

Abstract: Structured surfaces are described. In one embodiment, the structured surface comprises a plurality of structures having complement cumulative slope magnitude distribution (Fcc) such that at least 30, 40, 50, 60, 70, 80 or 90% of structures have a slope greater than 10 degrees; and less than 80% of the structures have a slope greater than 35 degrees. In other embodiments, the structures comprise peaks and valleys defined by a Cartesian coordinate system such that the peaks and valleys have a width and length in the x-y plane and a height in the z-direction and at least a portion of the peaks and/or valleys vary in height in the y direction and/or the x-direction by at least 10% of the average height. Articles and methods are also described.

Abstract: A rolling bearing includes an outer ring having an outer surface configured to be fitted into a first component, an inner ring having an inner surface configured to be fitted onto a second component, at least one rolling element arranged between the outer ring and the inner ring, and an antimony-free composite coating on the outer surface of the outer ring and/or the inner surface of the inner ring. The antimony-free composite comprises a binder and polytetrafluorethylene as a solid lubricant.

Abstract: Disclosed are smart glasses and a manufacturing method therefor. The smart glasses comprise a first assembly comprising a front crossbeam portion, a camera assembly and an optical mechanical assembly; and a second assembly comprising a rear crossbeam portion, a first temple and a second temple, wherein the first assembly is inserted into the second assembly. The first temple is provided with a first cavity; and the second temple is provided with a second cavity. A hollow passage for communicating the first cavity with the second cavity is enclosed by the front crossbeam portion and the rear crossbeam portion, the camera assembly is at least partially arranged in the first cavity, and the optical-mechanical assembly is at least partially arranged in the second cavity. The disclosed smart glasses have improved performance with enhanced convenience of assembly and ease of operation.

Abstract: A rolling bearing includes an outer ring having an outer surface configured to be fitted into a first component, an inner ring having an inner surface configured to be fitted onto a second component, at least one rolling element arranged between the outer ring and the inner ring, and a polymer composite sheet bonded to the outer surface of the outer ring and/or to the inner surface of the inner ring by a bonding agent.

Abstract: A rolling bearing includes an outer ring having an outer surface configured to be fitted into a first component, an inner ring having an inner surface configured to be fitted onto a second component, at least one rolling element arranged between the outer ring and the inner ring, and an antimony-free composite coating comprising a binder and a solid lubricant on the outer surface of the outer ring and/or the inner surface of the inner ring.

Abstract: A rolling bearing includes an outer ring having an outer surface configured to be fitted into a first component, an inner ring having an inner surface configured to be fitted onto a second component, at least one rolling element arranged between the outer ring and the inner ring, and a polymer composite sheet bonded on the outer surface of the outer ring and/or the inner surface of the inner ring by a bonding agent, where the polymer composite sheet includes at least one perfluoroalkyl and/or polyfluoroalkyl component.

Abstract: Disclosed is an aerosol generating device, which includes an outer housing, and an inner housing and an atomizing assembly disposed in the outer housing. A first liquid storage space is formed between the outer housing and the inner housing, a second liquid storage space is formed in the inner housing, a hole is disposed on the inner housing to communicate the first liquid storage space with the second liquid storage space, the atomizing assembly is disposed in the inner housing, and at least a part of the outer housing is made of a transparent or translucent material.

Abstract: Disclosed is an aerosol generating device, which includes a housing and a liquid storage cup mounted in the housing. A suction nozzle is disposed on the housing, a first liquid storage space is formed between the housing and the liquid storage cup, a second liquid storage space is formed in the liquid storage cup, a first sealing member is disposed between the housing and the liquid storage cup and at a side away from the suction nozzle, a second sealing member is disposed at a side of the second liquid storage space away from the suction nozzle, a third sealing member is disposed at a side of the liquid storage cup away from the suction nozzle, and the third sealing member is disposed at a side of the second sealing member away from the suction nozzle.

Abstract: The present invention provides Paraburkholderia sp. LSOJM18 and use thereof as well as a microbial inoculum, belonging to the technical field of microorganisms. The Paraburkholderia sp. LSOJM18 was deposited to the China Center for Type Culture Collection on Dec. 29, 2022, with the depository number CCTCCNO: M20222102. With a strong phosphate solubilization capacity, the strain provided by the present invention is suitable for activating phosphorus in farmland soil. Using the phosphate-solubilizing bacteria can significantly increase the available phosphorus content of soil and reduce the application of chemical phosphate fertilizers. Acting on a wide range of substrates, the phosphate-solubilizing bacteria strain provided by the present invention can not only secrete phosphatase to hydrolyze organic phosphorus, but also release small molecules such as organic acids, etc.

Abstract: An oscillator includes a resonator, sustaining circuit and detector circuit. The sustaining circuit receives a sense signal indicative of mechanically resonant motion of the resonator generates an amplified output signal in response. The detector circuit asserts, at a predetermined phase of the amplified output signal, one or more control signals that enable an offset-reducing operation with respect to the sustaining amplifier circuit.