Abstract: The present disclosure provides a risk assessment method of water inrush in tunnels constructed in water-rich grounds. The method includes the following steps: simulating a tunnel excavation process by finite element software MIDAS GTS NX and fluid-structure interaction; according to a research method of control variables, analyzing effects of a groundwater level, an elastic modulus and advanced pipe shed grouting on the stability of surrounding rock, and improving an algorithm of a radial basis function (RBF) neural network using a Grey Relation Analysis (GRA)-based Partitioning Around Medoid (PAM) clustering algorithm to assess risks of water inrush occurring in Qingdao area.

Abstract: Provided is the carbonyl heterocyclic compound shown in formula (I) or a pharmaceutically acceptable salt thereof, capable of being used as a compound having a targeted lanthionine synthetase C-like protein 2 pathway and being used for the treatment of various conditions, including infectious diseases, autoimmune diseases, diabetes, and chronic inflammatory diseases.

Abstract: A control process of inclusions in ultra-clean rare earth steel, wherein the content of rare earth elements REM in the ultra-clean rare earth steel, the total oxygen content T[O]m, the total sulfur content T[S]m in the steel, and the total oxygen content T[O]r in a rare earth metal or alloy added to the steel are controlled to satisfy the following formula: ?500<REM?(m*T[O]m+n*T[O]r+k*T[S]m)<?30, where REM is the content of rare earth elements in the steel, in ppm; T[O]m is the total oxygen content in the steel, in ppm; T[O]r is the total oxygen content in a rare earth metal or alloy added to the steel, in ppm; T[S]m is the total sulfur content in the steel, in ppm; m is a first correction coefficient, with a value of 2-4.5;n is a second correction coefficient; and k is a third correction coefficient.

Abstract: Provided in the present application are a rare-earth microalloyed steel and a control process. The steel has a special microstructure, and the microstructure comprises a rare earth-rich nanocluster having a diameter of 1-50 nm. The nanocluster has the same crystal structure type as a matrix. The rare earth-rich nanocluster inhibits the segregation of the elements S, P and As on a grain boundary, and obviously improves the fatigue life of the steel. In addition, a rare-earth solid solution also directly affects a phase change dynamics process so that the diffusion-type phase change starting temperature in the steel changes at least to 2° C., and even changes to 40-60° C. in some kinds of steel, thereby greatly improving the mechanical properties thereof, and providing a foundation for the development of more kinds of high-performance steel.

Abstract: Provided in the present application are a rare-earth microalloyed steel and a control process. The steel has a special microstructure, and the microstructure comprises a rare earth-rich nanocluster having a diameter of 1-50 nm. The nanocluster has the same crystal structure type as a matrix. The rare earth-rich nanocluster inhibits the segregation of the elements S, P and As on a grain boundary, and obviously improves the fatigue life of the steel. In addition, a rare-earth solid solution also directly affects a phase change dynamics process so that the diffusion-type phase change starting temperature in the steel changes at least to 2° C., and even changes to 40-60° C. in some kinds of steel, thereby greatly improving the mechanical properties thereof, and providing a foundation for the development of more kinds of high-performance steel.

Abstract: Provided are an ultra-clean rare earth steel and an occluded foreign substance modification control method, the steel includes 10-200 ppm of rare earth elements, 50% or more occluded foreign substances in the steel are dispersed into RE-oxygen-sulfide with the average equivalent diameter Dmean ranging from 1-5 ?m in a spherical shape or a substantially spherical shape or a granular shape; according to the method, at least 80%, preferably at least 90%, of Al2O3 occluded foreign substances in the steel are modified into RE-oxygen-sulfide, compared with steel with the same components without rare earth, the total amount of the occluded foreign substances in the steel is reduced by 18% or higher, the cracking probability caused by occluded foreign substances such as Al2O3 in traditional pure steel is reduced, the mechanical performance such as the fatigue life of the steel is remarkably improved.

Abstract: The present invention includes methods for treating and/or preventing a viral or virally-induced tissue dysfunction or failure in a patient comprising administering an inhibitor of SARS-CoV-2 binding to L-SIGN in an amount effective to treat the viral or virally-induced tissue dysfunction or failure of cells do not express ACE2.

Abstract: The present invention includes a method of treating a bone disease caused by a intracellular protein trafficking defect comprising: identifying a subject having the bone disease caused by the intracellular protein trafficking defect in a membrane bound transcription factor peptidase, site 1 (MBTPS1) gene; and providing the subject with an effective amount of a composition that bypasses or corrects a defect in MBTPS1 gene expression, gene splicing, or corrects protein trafficking defects in the endoplasmic reticulum and to the lysosome.

Abstract: A population of cells possesses enhanced selectin binding based upon a fucosylated selectin ligand present on a surface thereof. Methods of producing the population of cells, along with therapeutic methods of using the cells, are also disclosed.

Abstract: A light-emitting diode epitaxial wafer, including: a substrate; and a buffer layer, an undoped GaN layer, an n-type GaN contact layer, a multi-quantum well layer, and a p-type GaN contact layer, which are sequentially laminated on the substrate in that order. The multi-quantum well layer includes GaN barrier layers and at least one InxGa1-xN well layer, where 0<X<1. At least part of the GaN barrier layers and the at least one InxGa1-xN well layer include a pre-grown layer provided therebetween; the pre-grown layer is made of InN, or the pre-grown layer is a superlattice structure including InN layers and GaN layers. When the pre-grown layer is a superlattice structure including InN layers and GaN layers, the InxGa1-xN well layer is adjacent to a GaN layer of the superlattice structure, and the thickness of the pre-grown layer is more than 0 nm and less than 0.3 nm.

Abstract: A population of cells possesses enhanced selectin binding based upon a fucosylated selectin ligand present on a surface thereof. Methods of producing the population of cells, along with therapeutic methods of using the cells, are also disclosed.

Abstract: A light-emitting diode epitaxial wafer, including: a substrate; and a buffer layer, an undoped GaN layer, an n-type GaN contact layer, a multi-quantum well layer, and a p-type GaN contact layer, which are sequentially laminated on the substrate in that order. The multi-quantum well layer includes GaN barrier layers and at least one InxGa1-xN well layer, where 0<X<1. At least part of the GaN barrier layers and the at least one InxGa1-xN well layer include a pre-grown layer provided therebetween; the pre-grown layer is made of InN, or the pre-grown layer is a superlattice structure including InN layers and GaN layers. When the pre-grown layer is a superlattice structure including InN layers and GaN layers, the InxGa1-xN well layer is adjacent to a GaN layer of the superlattice structure, and the thickness of the pre-grown layer is more than 0 nm and less than 0.3 nm.

Abstract: A population of cells possesses enhanced selectin binding based upon a fucosylated selectin ligand present on a surface thereof. Methods of producing the population of cells, along with therapeutic methods of using the cells, are also disclosed.

Abstract: A population of cells possesses enhanced selectin binding based upon a fucosylated selectin ligand present on a surface thereof. Methods of producing the population of cells, along with therapeutic methods of using the cells, are also disclosed.

Abstract: A method for controlling A-shaped segregation of steel ingot. The method includes: 1) controlling a content of phosphorus in liquid steel at less than or equal to 0.005 wt. % upon tapping from an electric furnace, preventing steel slag from entering a ladle, controlling content of harmful elements at less than or equal to 100 ppm; and adding between 3 and 15 kg of calcium oxide and less than or equal to 0.5 kg of aluminum to each ton of the liquid steel; 2) pre-deoxidizing the liquid metal using vacuum carbon deoxidation; 3) de-sulfurizing, controlling content of oxygen, and controlling the content of sulfur in the liquid steel at less than or equal to 0.005 wt. %; and 4) performing vacuum degasification, controlling the total oxygen content at less than or equal to 15 ppm; and casting the steel in the presence of inert gas or in vacuum.

Abstract: The present invention relates generally to the use of modulators of podoplanin (PDPN) mediated platelet activation. For example, an agonist or mimic of podoplanin (PDPN)/C-type lectin-like receptor 2 (CLEC-2) signaling may be used to inhibit vascular leakage or promote vascular integrity. Alternatively, an antagonist of podoplanin (PDPN)/C-type lectin-like receptor 2 (CLEC-2) signaling may be used to inhibit platelet activation.

Abstract: A method for controlling A-shaped segregation of steel ingot. The method includes: 1) controlling a content of phosphorus in liquid steel at less than or equal to 0.005 wt. % upon tapping from an electric furnace, preventing steel slag from entering a ladle, controlling content of harmful elements at less than or equal to 100 ppm; and adding between 3 and 15 kg of calcium oxide and less than or equal to 0.5 kg of aluminum to each ton of the liquid steel; 2) pre-deoxidizing the liquid metal using vacuum carbon deoxidation; 3) de-sulfurizing, controlling content of oxygen, and controlling the content of sulfur in the liquid steel at less than or equal to 0.005 wt. %; and 4) performing vacuum degasification, controlling the total oxygen content at less than or equal to 15 ppm; and casting the steel in the presence of inert gas or in vacuum.

Abstract: A method of in vitro fucosylation of selectin ligands on cord blood-derived hematopoietic stem cells for bone marrow transplantation is disclosed. In this method, an effective amount of an ?1,3-fucosyltransferase, e.g., ?1,3-fucosyltransferase VI, is used in vitro to treat cord blood-derived hematopoietic stem cells to convert non-functional PSGL-1 or other ligands on the cell surface into functional forms that bind selectins, especially P-selectin or E-selectin. The treated cells have enhanced effectiveness in reconstituting bone marrow in patients in need of such therapy.

Abstract: A population of cells possesses enhanced selectin binding based upon a fucosylated selectin ligand present on a surface thereof. Methods of producing the population of cells, along with therapeutic methods of using the cells, are also disclosed.