Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.

Abstract: An endoscope locking device comprises: a pedestal, a lock buckle and an elastic element, the pedestal is provided with a slot for mounting the lock buckle, the lock buckle is provided with an oblong hole in the center, and the lock buckle is mounted within the slot of the pedestal, and the lock buckle may reciprocate within the slot; and the lock buckle and the pedestal are elastically connected by the elastic element. The endoscope is fixed by using the elasticity of the elastic rubber ring to the endoscope locking device formed by the lock buckle and the pedestal.

Abstract: A magnetic resonance imaging apparatus according to an aspect of the present disclosure includes a sequence controlling circuit and a processing circuit. The sequence controlling circuit is configured to acquire undersampled frequency domain scan data by executing a pulse sequence while carrying out an undersampling process. The processing circuit is configured: to generate image domain corrected data of the frequency domain scan data, by correcting the frequency domain scan data in an image domain; to generate frequency domain corrected data of the frequency domain scan data by correcting the frequency domain scan data in a frequency domain; to optimize the frequency domain scan data based on the image domain corrected data and the frequency domain corrected data; and to reconstruct image data by using the optimized frequency domain scan data.

Abstract: Provided in the present invention is an enzyme reaction solution for constructing a sequencing library and the use thereof. The enzyme reaction solution comprises an enzyme composition and a reaction buffer, wherein the enzyme composition comprises a nucleic acid endonuclease, a DNA polymerase, and a polynucleotide kinase; and the reaction buffer comprises a metal salt, a substrate, and a buffer medium aqueous solution. The present application aims to optimize the formulation of an enzyme reaction solution. The cleavage, terminal repair and addition of A to the terminal of a nucleic acid sample is achieved by a one-step reaction. In a suitable buffer system, the enzyme digestion reaction rate and the terminal repair reaction rate reach a balance. In the case where the initial amount of the sample is 100 pg to 1 µg and the processing time is the same, a sequencing library with a consistent length distribution is obtained.

Abstract: Provided are novel heteroaromatic compound as an Autotaxin inhibitor, a pharmaceutical composition comprising the compound, and a use thereof in a treatment of a disease with a pathological feature of Autotaxin overexpression in a mammal, wherein the compound is according to formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, nitrogen oxide, metabolite, prodrug, or mixture thereof; wherein each of R1, Ar1, Ar2, Ar3, W, Y, Z, and Cy is defined in the present disclosure.

Abstract: An electronic device may have an antenna embedded in a substrate. The substrate may have first layers, second layers on the first layers, and third layers on the second layers. The antenna may include a first patch on the first layers that radiates in a first band, a second patch on the second antenna layers that radiates in a second band, and a parasitic patch on the third layers. A short path may couple ground to a location on the first patch that allows the first patch to form a ground extension in the second band for the second patch without affecting performance of the first patch in the first band. The first layers may have a higher dielectric permittivity than the second and third layers to minimize the thickness of the substrate without requiring a separate dielectric loading layer over the substrate.

Abstract: The disclosure discloses a spinning process of a magnesium alloy wheel hub, which comprises the following steps: step 1, heating a magnesium alloy bar at 350-430° C. and keeping the temperature for 20 minutes; step 2, initially forging and forming on the bar under a forging press, wherein the forging down-pressing speed is 6-15 mm/s; step 3, finally forging and forming on the bar under a forging press, wherein the forging down-pressing speed is 5-8 mm/s; step 4, stress relief annealing on the final forged magnesium alloy blank; step 5, solid dissolving on the annealed magnesium alloy blank; step 6, taking out the solid-dissolved blank and directly spinning by a spinning machine; step 7, heating treatment and aging treatment. The magnesium alloy wheel hub with excellent performance is obtained by the process, and the spinning process and processing efficiency are greatly improved.

Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a processing circuitry configured to generate a pulse sequence including a plurality of repetition times (TRs) each of which includes an echo train and a driven equilibrium pulse applied following the echo train, vary a flip angle of the driven equilibrium pulse, obtain magnetic resonance image data collected by executing the pulse sequence, and reconstruct a magnetic resonance image by using the magnetic resonance image data.

Abstract: An adjustable endoscope fixing device, comprises a tail bed, a three-way connector and a locking screw; an outer wall surface of a straight column section of the tail bed is provided with a rectangular slot; and an outer wall surface of a first connecting end of the three-way connector is provided with a locking structure, and the straight column section of the tail bed is connected to the first connecting end of the three-way connector, and the tail bed is fixed to the three-way connector by the locking structure.

Abstract: Provided herein are crystalline forms of a triazolopyrimidine compound, which is useful for treating a PRC2-mediated disease or disorder.

Abstract: A bladder-type pressure tank includes an outer shell, a bladder, a nozzle, and an elbow pipe. The outer shell includes a liner and a glass-fiber layer covering the outer surface of the liner. The liner includes polyethylene (PE). The liner further includes a chamber, a first opening, and a second opening. The bladder is disposed in the chamber. In an inflated state of the bladder, a gap is formed between the inflated bladder and the inner surface of the liner. The bladder includes polyurethane (PU). The nozzle is integrated with the bladder, and is disposed in the first opening and seals the first opening. The elbow pipe includes a first end and a second end. The first end of the elbow pipe is disposed in the second opening and communicates with the chamber; and the second end of the elbow pipe is configured to connect to a pipeline.

Abstract: A two-stage energy dissipation type shed tunnel support structure connected by a principle of Dougong and a design method thereof are provided. The two-stage energy dissipation type shed tunnel support structure includes a Dougong joint domain, crossbeams and columns. The Dougong joint domain includes section steel members, wavy-wall cylindrical elastoplastic buffers, U-shaped sliding connecting troughs and high-strength bolts. Multiple layers of the section steel members are orthogonally stacked to form a Dougong shape, the wavy-wall cylindrical elastoplastic buffers are arranged between adjacent layers of the section steel members, and the U-shaped sliding connecting troughs are arranged at upper and lower ends of the wavy-wall cylindrical elastoplastic buffers, which realizes a connection between the wavy-wall cylindrical elastoplastic buffers and a section steel in two orthogonal directions.

Abstract: A method for cracking crude oil includes delivering the crude oil to a first tube group of a convection section of a cracking furnace for preheating and then performing vaporization to obtain a first gas phase and a first liquid phase; performing high-pressure extraction on the first liquid phase to obtain a non-asphalt oil and an asphalt; and mixing the first gas phase and the non-asphalt oil with water vapor respectively, or mixing the first gas phase with the non-asphalt oil prior to mixing with water vapor, then delivering the same to a second tube group of the convection section of the cracking furnace for heating, followed by delivering same to a radiation section of the cracking furnace for cracking to obtain a cracked product, and separating the cracked product to obtain low-carbon olefins.

Abstract: An electronic device may be provided with a phased antenna array on an antenna module. The array may include low band antennas and high band antennas that radiate at frequencies greater than 10 GHz. The module may include antenna layers, transmission line layers, and ground traces that separate the antenna layers from the transmission line layers. The low band antennas and the high band antennas may have radiators patterned onto the antenna layers. The radiators may be fed by transmission lines on the transmission line layers. The antenna layers may have a dielectric permittivity that is greater than the dielectric permittivity of the transmission line layers. This may serve to reduce the lateral footprint of the low band and high band antennas, which allows the antennas to be interleaved along a common linear axis in the phased antenna array, thereby minimizing the lateral footprint of the antenna module.

Abstract: An electronic device may have an antenna embedded in a substrate. The substrate may have first layers, second layers on the first layers, and third layers on the second layers. The antenna may include a first patch on the first layers that radiates in a first band, a second patch on the second antenna layers that radiates in a second band, and a parasitic patch on the third layers. A short path may couple ground to a location on the first patch that allows the first patch to form a ground extension in the second band for the second patch without affecting performance of the first patch in the first band. The first layers may have a higher dielectric permittivity than the second and third layers to minimize the thickness of the substrate without requiring a separate dielectric loading layer over the substrate.

Abstract: An electronic device may have a cover layer and an antenna. A dielectric adapter may have a first surface coupled to the antenna and a second surface pressed against the cover layer. The cover layer may have a three-dimensional curvature. The second surface may have a curvature that matches the curvature of the cover layer. Biasing structures may exert a biasing force that presses the antenna against the dielectric adapter and that presses the dielectric adapter against the cover layer. The biasing force may be oriented in a direction normal to the cover layer at each point across dielectric adapter. This may serve to ensure that a uniform and reliable impedance transition is provided between the antenna and free space through the cover layer over time, thereby maximizing the efficiency of the antenna.

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.

Abstract: Provided is a wheel spinning die wherein the plurality of identical slide blocks are connected end to end to form a circular ring, and the slide blocks are inserted into an annular groove between the side wall of a circular groove at the upper end of the lower die and the central connecting block; during spinning, each arc flange is clamped at the joint of an outer wheel lip and a rim under a spoke; and during die releasing, the slide blocks can move up and down together with the vertical movement of a wheel blank, so that the problem of releasing of a reverse draft die at the joint of the cold spinning wheel rim and the outer wheel lip can be solved, wheel damage caused by die releasing can be eliminated, and the yield and production efficiency of wheels are improved.

Abstract: A flexible glass protective net with landscape function for falling objects and a design method thereof includes flexible support ropes, buckling clamps, articulated pieces, glass plates and seam rubber strips; the flexible support ropes are arranged crosswise in a grid shape, the buckling clamps are arranged at grid nodes, and the glass plates are arranged in the grids; the glass plate includes pieces of glass, and the pieces of glass are connected by the seam rubber strips at seams; the glass is clamped and fixed by the articulated piece, the tail end of the articulated piece is connected to the buckling clamp, and the glass plate is connected to the buckling clamp via the articulated piece; mutually crossing and separated slots are reserved in the buckling clamps, and the flexible support ropes at the grid nodes respectively pass through the slots.

Abstract: An electronic device may include first and second phased antenna arrays that convey radio-frequency signals at frequencies greater than 10 GHz. The second array may have fewer antennas than the first array. Control circuitry may control the first and second arrays in a diversity mode and in a simultaneous array mode. In the diversity mode, the first array may form a first signal beam while the second array is inactive. When the first array is blocked by an object or otherwise exhibits unsatisfactory performance, the second array may form a second signal beam while the first array is inactive. In the simultaneous mode, the first and second arrays may form a combined array that produces a third signal beam. The combined array may maximize gain. Hierarchical beam searching operations may be performed. The arrays may be distributed across one or more modules.