Patents by Inventor Lilach Hedvati

Lilach Hedvati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Raltegravir Salts And Crystalline Forms Thereof
    Publication number: 20140256755
    Abstract: The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 11, 2014
    Applicant: Teva Pharmaceutical Industries LTD
    Inventors: Ana KWOKAL, Lilach HEDVATI, Revital BURSTEIN, Adi YEORI, Rinat MOSHKOVITS-KAPTSAN
  • Raltegravir salts and crystalline forms thereof
    Patent number: 8722722
    Abstract: The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: May 13, 2014
    Assignee: Teva Pharmaceutical Industries Ltd
    Inventors: Ana Kwokal, Lilach Hedvati, Revital Burstein, Adi Yeori, Rinat Moshkovits-Kaptsan
  • Raltegravir Salts and Crystalline Forms Thereof
    Publication number: 20130096147
    Abstract: The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium.
    Type: Application
    Filed: December 7, 2012
    Publication date: April 18, 2013
    Inventors: Ana KWOKAL, Lilach Hedvati, Revital Burstein, Adi Yeori, Rinat Moshkovits-Kaptsan
  • RALTEGRAVIR SALTS AND CRYSTALLINE FORMS THEREOF
    Publication number: 20130079360
    Abstract: The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium.
    Type: Application
    Filed: April 1, 2011
    Publication date: March 28, 2013
    Inventors: Ana Kwokal, Lilach Hedvati, Revital Burstein, Adi Yeori, Rinat Moshkovits-Kaptsan
  • Method for the preparation of Pregabalin and salts thereof
    Patent number: 7763749
    Abstract: Processes for preparing and purifying Pregabalin and salts thereof are provided.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: July 27, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Ziv Dee Noor, Claude Singer, Gideon Pilarski
  • Preparation of Retapamulin via its Pleuromutilin-thiol precursor
    Publication number: 20100184987
    Abstract: Provided are processes for preparation of Retapamulin via its pleuromutilin-thiol precursor.
    Type: Application
    Filed: November 12, 2009
    Publication date: July 22, 2010
    Inventors: Nimer Jaber, Lilach Hedvati, Eyal Gilboa, Sharon Avhar-Maydan
  • STEREOSELECTIVE ENZYMATIC SYNTHESIS OF (S) OR (R)-ISO-BUTYL-GLUTARIC ESTER
    Publication number: 20100087525
    Abstract: The present invention relates to a stereoselective enzymatic synthesis of (S) or (R)-iso-butyl-glutaric ester, an intermediate of S-Pregabalin.
    Type: Application
    Filed: June 23, 2009
    Publication date: April 8, 2010
    Inventors: Lilach Hedvati, Greta Sterimbaum, Yuriy Raizi, Rahamin Aminov
  • Purification of olmesartan medoxomil
    Publication number: 20100076200
    Abstract: The present invention provides a process for purifying olmesartan medoxomil.
    Type: Application
    Filed: September 17, 2009
    Publication date: March 25, 2010
    Inventors: Lilach Hedvati, Gideon Pilarsky, Yuriy Raizi, Esti Esty Marom
  • Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
    Patent number: 7678938
    Abstract: The invention relates to pure (R)-CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)-CMH and to the process for isolating (S)-CMH from the mother liquor.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: March 16, 2010
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Ziv Dee-Noor, Claude Singer, Gideon Pilarski
  • Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
    Patent number: 7619112
    Abstract: The invention relates to pure (R)—CMH and to the optical resolution of CMH-racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)—CMH and to the process for isolating (S)—CMH from the mother liquor.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: November 17, 2009
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Ziv Dee-Noor, Claude Singer, Gideon Pilarski
  • Amorphous retapamulin and processes for preparation thereof
    Publication number: 20090234125
    Abstract: An amorphous form of Retapamulin, preferably in powder form, and processes for preparation thereof, are provided. Amorphous Retapamulin of the present invention can contain less than about 10 percent crystallinity, preferably less than about 5 percent crystallinity. Pharmaceutical compositions comprising amorphous Retapamulin are also provided.
    Type: Application
    Filed: November 26, 2008
    Publication date: September 17, 2009
    Inventors: Eli Lancry, Lilach Hedvati, Greta Sterimbaum, Ariel Mittelman, Tali Katav
  • Olmesartan medoxomil with reduced levels of impurities
    Publication number: 20090209603
    Abstract: The present invention provides the preparation of olmesartan medoxomil containing less than about 0.1% of one or more of the impurities OLM-Me, OLM-Cl, and OLM-eliminate.
    Type: Application
    Filed: February 19, 2009
    Publication date: August 20, 2009
    Inventors: Lilach Hedvati, Gideon Pilarski
  • Olmesartan medoxomil with reduced levels of impurities
    Patent number: 7563814
    Abstract: The present invention provides the preparation of olmesartan medoxomil containing less than about 0.1% of one or more of the impurities OLM-Me, OLM-Cl, and OLM-eliminate.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: July 21, 2009
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Gideon Pilarsky
  • Process for the preparation of Retapamulin and its intermediates
    Publication number: 20090149655
    Abstract: Processes for preparing tropine derivatives of the following Formula B are provided where LG represents a leaving group. The tropine derivatives may be used to prepare Retapamulin, preferably in substantially pure form.
    Type: Application
    Filed: December 5, 2008
    Publication date: June 11, 2009
    Inventors: Lilach Hedvati, Eyal Gilboa, Sharon Avhar-Maydan, Sharona Shachan-Tov
  • PREGABALIN -4-ELIMINATE, PREGABALIN 5-ELIMINATE, THEIR USE AS REFERENCE MARKER AND STANDARD, AND METHOD TO PRODUCE PREGABALIN CONTAINING LOW LEVELS THEREOF
    Publication number: 20090137842
    Abstract: The present invention provides 3-(aminomethyl)-5-methylhex-4-enoic acid (Pregabalin-4-eliminate or PRG-4E) and 3-(aminomethyl)-5-methylhex-5-enoic acid (Pregabalin-5-eliminate or PRG-5E), and their uses as reference markers and standards for determining the purity of Pregabalin. The invention also provides a method to produce Pregabalin containing low levels of these impurities.
    Type: Application
    Filed: October 3, 2008
    Publication date: May 28, 2009
    Inventors: Yuri VOLLERNER, Yanai Golub, Lilach Hedvati, Yuriy Raizi, Mirit Leibovich, Amihai Eisenstadt, Rahamin Aminov
  • Preparation of olmesartan medoxomil
    Patent number: 7528258
    Abstract: The present invention provides a process for preparing olmesartan medoxomil.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: May 5, 2009
    Assignee: Teva Pharmaceutical Industries Ltd
    Inventors: Lilach Hedvati, Gideon Pilarsky
  • Pregabalin free of lactam and a process for preparation thereof
    Patent number: 7488846
    Abstract: The present invention encompasses Pregabalin substantially free of Lactam and a process for obtaining Pregabalin substantially free of Lactam comprising extracting an acidic mixture containing a complex of Pregabalin with a strong mineral acid, with C3-8 alcohol; and combining the organic phase with an organic base.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: February 10, 2009
    Assignee: Teva Pharmaceuical Industries Ltd.
    Inventors: Lilach Hedvati, Gideon Pilarski, Yuriy Raizi, Sharon Tomer, Ziv Dee-Noor, Claude Singer
  • Pregabalin free of isobutylglutaric acid and a process for preparation thereof
    Patent number: 7462737
    Abstract: A Pregabalin having a low level of 3-isobutylglutaric acid is provided.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: December 9, 2008
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Ziv Dee-Noor, Claude Singer, Gideon Pilarski, Yuriy Raizi, Sharon Tomer
  • Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
    Patent number: 7462738
    Abstract: Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: December 9, 2008
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Lilach Hedvati, Eyal Gilboa, Sharon Avhar-Maydan
  • Crystalline forms of pregabalin
    Patent number: 7417165
    Abstract: Crystalline form of Pregabalin characterized by X-ray powder diffraction peaks at about 5.8, 18.4, 19.2, 20.7, and 23.7° 2?±0.2° 2?, methods for its preparation, its pharmaceutical compositions thereof, and methods for the preparation of crystalline form of Pregabalin characterized by X-ray powder diffraction peaks at about 5.7, 15.4, 17.2, 18.2, and 23.0° 2?±0.2° 2?, are provided.
    Type: Grant
    Filed: April 6, 2006
    Date of Patent: August 26, 2008
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Judith Aronhime, Sigalit Levi, Lilach Hedvati