Patents by Inventor Lilach Tencer

Lilach Tencer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic implications of dickkopf affecting cancer stem cell fate
    Patent number: 8762069
    Abstract: A method of determining a therapeutic regimen for the treatment of cancer with Dickkopf (Dkk) protein in which a mathematical model of differential equations describing the major signaling pathways involved in stem cell regulation is created and used to simulate signals from the cancer stem cell environment based upon administration of at least a single dose of Dkk in vitro and/or in vivo. A method of modulating cancer stem cells is also provided in which the stem cell computer model is simulates the effect of Dkk and performs a calibration test to determine a threshold value above which Dkk induces cell differentiation and a threshold value below which Dkk induces stem cell proliferation.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: June 24, 2014
    Assignee: Institute for Medical Biomathematics
    Inventors: Zvia Agur, Oleg U. Kirnasovsky, Yuri Kogan, Lilach Tencer
  • THERAPEUTIC IMPLICATIONS OF DICKKOPF AFFECTING CANCER STEM CELL FATE
    Publication number: 20100235150
    Abstract: A method of determining a therapeutic regimen for the treatment of cancer with Dickkopf (Dkk) protein in which a mathematical model of differential equations describing the major signaling pathways involved in stem cell regulation is created and used to simulate signals from the cancer stem cell environment based upon administration of at least a single dose of Dkk in vitro and/or in vivo. A method of modulating cancer stem cells is also provided in which the stem cell computer model is simulates the effect of Dkk and performs a calibration test to determine a threshold value above which Dkk induces cell differentiation and a threshold value below which Dkk induces stem cell proliferation.
    Type: Application
    Filed: March 11, 2010
    Publication date: September 16, 2010
    Inventors: Zvia AGUR, Oleg U. Kirnasovsky, Yuri Kogan, Lilach Tencer