Abstract: The present disclosure provides a method for mapping one or more analytes that contact a biological structure. The method uses surface-enhanced Raman spectroscopy and includes contacting the biological structure and a metallic nanoparticle. The method further includes collecting a spectrum with a Raman spectrometer. The method further includes determining a location of the analyte along at least one of an x-direction, a y-direction and a z-direction on the structure.

Abstract: Techniques for optimizing a magnetic resonance imaging (MRI) protocols are described herein. An example method can include receiving one or more MRI scanner settings for an imaging sequence; selecting at least one objective function from a plurality of objective functions; selecting an acquisition train length; selecting a k-space strategy; selecting one or more imaging parameters; and acquiring a magnetic resonance (MR) image using at least one of an optimized k-space strategy, an optimized acquisition train length, or optimized imaging parameters.

Abstract: Systems and methods are provided herein for the extraction, detection and measurement of MNPs in complex matrices in particular, the method includes mixing a solution including a predetermined organic substance with a matrix including the metal nanoparticles, the predetermined organic substance adapted to bind to the metal nanoparticles, to facilitate extraction by an organic solvent and to provide a distinct SERS signal, the mixing resulting in a suspension, adding a solution of a predetermined organic extraction solvent to the suspension, extracting and separating the metal nanoparticles; the metal nanoparticles, after extraction, functionalized by binding with the predetermined organic substance, and extracting and separating the metal nanoparticles; the metal nanoparticles, after extraction, functionalized by binding with the predetermined organic substance; and performing SERS imaging on the functionalized metal nanoparticles in order to detect metals nanoparticles.

Abstract: A bacterial detection platform integrating the sensitive SERS technique and the advanced mapping technique. Bacterial cells on the SERS substrate are detected using the mapping technique. The identification is based on the fingerprint of the bacterial SERS spectra. The quantification of the cells is based on the mapping technique. For different applications, silver or gold nanoparticles can be integrated onto a filter membrane for concentration and detection of bacterial cells in water or silver dendrites can be used as the SERS substrate. The SERS substrates are also modified with capturers and fixed in a vessel to concentrate cells from complex liquid matrices.

Abstract: Disclosed is a hand-held, medical, multi-channel biological information acquisition mobile terminal system, comprising two signal sensing gloves RL with a cable end embedded therein, for use in acquiring a variety of biological signals comprising multi-channel interconnected ECG, heart sounds, finger blood volume pulse, and skin impedance etc., the signal sensing gloves RL also comprising a signal acquisition device S, a signal transmission device C connected to the signal acquisition device S, and a mobile terminal T connected wirelessly or with a wired connection. The system has the characteristics of low power consumption, small size, low cost and fewer control channels needed for multi-channel connection; and the system can achieve on-site acquisition of a variety of biological information and the mobile function of electronic health records.

Abstract: A method for manufacturing compatible vertical double diffused metal oxide semiconductor (VDMOS) transistor and lateral double diffused metal oxide semiconductor (LDMOS) transistor includes: providing a substrate having an LDMOS transistor region and a VDMOS transistor region; forming an N-buried region in the substrate; forming an epitaxial layer on the N-buried layer region; forming isolation regions in the LDMOS transistor region and the VDMOS transistor region; forming a drift region in the LDMOS transistor region; forming gates in the LDMOS transistor region and the VDMOS transistor region; forming PBODY regions in the LDMOS transistor region and the VDMOS transistor region; forming an N-type GRADE region in the LDMOS transistor region; forming an NSINK region in the VDMOS transistor region, where the NSINK region is in contact with the N-buried layer region; forming sources and drains in the LDMOS transistor region and the VDMOS transistor region; and forming a P+ region in the LDMOS transistor region,

Abstract: A method for manufacturing compatible vertical double diffused metal oxide semiconductor (VDMOS) transistor and lateral double diffused metal oxide semiconductor (LDMOS) transistor includes: providing a substrate having an LDMOS transistor region and a VDMOS transistor region; forming an N-buried region in the substrate; forming an epitaxial layer on the N-buried layer region; forming isolation regions in the LDMOS transistor region and the VDMOS transistor region; forming a drift region in the LDMOS transistor region; forming gates in the LDMOS transistor region and the VDMOS transistor region; forming PBODY regions in the LDMOS transistor region and the VDMOS transistor region; forming an N-type GRADE region in the LDMOS transistor region; forming an NSINK region in the VDMOS transistor region, where the NSINK region is in contact with the N-buried layer region; forming sources and drains in the LDMOS transistor region and the VDMOS transistor region; and forming a P+ region in the LDMOS transistor region,