Patents by Inventor Lili YUE

Lili YUE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MAGE-B2-SPECIFIC T-CELL RECEPTORS
    Publication number: 20240100162
    Abstract: Provided herein are T-cell receptors (TCRs) that when expressed recombinantly on the surface of a T cell are able to recognize the MAGE-B2-derived peptide GVYDGEEHSV (SEQ ID NO: 1) when presented by HLA-A*02:01 sufficiently to activate the recombinant T cell. Certain TCRs provided herein also are able to recognize the MAGE-A4-derived peptide GVYDGREHTV (SEQ ID NO:2) sufficiently to activate the recombinant T cell. Importantly, exemplary TCRs provided herein were thoroughly screened for lack of cross-reactivity with similar peptides that may be presented by normal cells or tissue and for alloreactivity.
    Type: Application
    Filed: December 21, 2021
    Publication date: March 28, 2024
    Applicant: AMGEN INC.
    Inventors: Sungeun KIM, Yan ZHENG, Dhanashri S. BAGAL, Lili YUE