Patents by Inventor Lilianne K. Bar

Lilianne K. Bar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6156337
    Abstract: A method for loading liposomes with biopolymeric substances functional in humans involves combining a physiologically compatible solution of the biopolymeric substances with one or more dry, liposome-forming lipids, effecting a lipid-containing fraction, combining the lipid-containing fraction with an organic solvent, effecting an organic solvent fraction, and drying the organic solvent fraction, which effects a dry fraction of liposomes loaded with the biopolymeric substances.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: December 5, 2000
    Assignee: Opperbas Holding B.V.
    Inventors: Yechezkel Barenholz, Israel Nur, Lilianne K. Bar, Dvorah Diminsky, Moshe Baru
  • Patent number: 6066331
    Abstract: A composition useful for preparing vesicles loaded with biological cell-structures, biopolymers and/or -oligomers is prepared by solubilizing amphiphatic material such as a phospholipid in a polar-protic solvent miscible with water, solubilizing biological cell-structures, biopolymers and/or -oligomers in an aqueous medium, mixing the polar-protic solvent containing the amphiphatic material with the aqueous medium containing the biological cell-structures, biopolymers and/or -oligomers, and lyophilizing the resultant mixture to form a dry product. The dry product is hydrated in an aqueous medium to form the loaded vesicles. The polar-protic solvent may be tert-butanol, and the aqueous medium may contain a salt such as sodium chloride, an isoosmotic cryoprotectant such as lactose, sucrose or trehalose, or a mixture of the salt and the cryoprotectant. A medicament for disease treatment is formed by mixing the loaded vesicles with a pharmaceutically acceptable vehicle.
    Type: Grant
    Filed: August 13, 1996
    Date of Patent: May 23, 2000
    Inventors: Yechezkel Barenholz, Lilianne K. Bar, Dvorah Diminsky, Moshe Baru