Patents by Inventor Lilias G. Rees

Lilias G. Rees has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substantially pure diastereoisomers of tetrahydrofolate derivatives
    Patent number: 6500829
    Abstract: The present invention related to the preparation of substantially pure diastereoisomers of derivatives of tetrahydrofolate and the use of such diastereoisomers. More particularly the present invention provides a process for the preparation of a desired substantially pure (6R or 6S) diastereoisomer of a derivative of tetrahydrofolic acid or salt or ester. The process comprises the steps of: attaching a chiral auxiliary group at either N-5 or N-10 of a mixture of 6R and 6S diastereoisomers of tetrahydrofolic acid, separating the new diastereoisomers, recovering the desired new diastereoisomer (6R or 6S) corresponding to the desired (6R or 6S) diastereoisomer, and converting the substantially pure new diastereoisomer recovered into the corresponding diastereoisomer.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: December 31, 2002
    Assignee: University of Strathclyde
    Inventors: Hamish Christopher Swan Wood, Colin James Suckling, Lilias G. Rees
  • Process for preparing substantially pure diastereoisomers of tetrahydrofolic derivatives
    Patent number: 4959472
    Abstract: The present invention related to the preparation of substantially pure diastereoisomers of derivatives of tetrahydrofolate and the use of such diastereoisomers. More particularly the present invention provides a process for the preparation of a desired substantially pure (6R or 6S) diastereoisomer of a derivative of tetrahydrofolic acid or salt or ester. The process comprises the steps of: attaching a chiral auxiliary group at either N-5 or N-10 of a mixture of 6R and 6S diastereoisomers of tetrahydrofolic acid, separating the new diastereoisomers, recovering the desired new diastereoisomer (6R or 6S) corresponding to the desired (6R or 6S) diastereoisomer, and converting the substantially pure new diastereoisomer recovered into the corresponding diastereoisomer.
    Type: Grant
    Filed: September 1, 1989
    Date of Patent: September 25, 1990
    Assignee: University of Strathclyde
    Inventors: Hamish C. S. Wood, Colin J. Suckling, Lilias G. Rees