Abstract: A degassing method for a multiple catheter fluid management system includes injecting a first fluid at a low pressure from a first fluid source into a first fluid source connection of a hemostasis valve, closing a first valve at the first fluid source connection, applying vacuum to a sink connection of the hemostasis valve to remove residual first fluid into a sink connected to the sink connection, closing a sink valve at the sink connection, and injecting a second fluid from a second fluid source into a second fluid source connection of the hemostasis valve.

Abstract: A catheter system with integrated fluidics management includes a first elongate, flexible tubular body having a proximal end, a distal end and at least one lumen, a hub on the proximal end of the tubular body, a valve system in communication with the hub, and a first port, a second port, and a third port in communication with the valve system. The valve system is configured to selectively place any one of the first port, the second port and the third port into communication with the lumen while simultaneously blocking the other two ports from communicating with the lumen.

Abstract: A method of achieving supra aortic access includes the steps of providing an assembly including a guidewire, an access catheter and a guide catheter, coaxially moveably assembled into a single multi-catheter assembly, coupling the assembly to a drive system, driving the assembly to an aortic arch, and advancing the access catheter to achieve supra-aortic access to a branch vessel off of the aortic arch.

Abstract: A method of performing a neurovascular procedure includes providing a multi-catheter assembly including an access catheter, a guide catheter, and a procedure catheter, coupling the assembly to a robotic drive system, driving the assembly to achieve supra-aortic access, and driving a subset of the assembly to a neurovascular site. The subset includes the guide catheter and the procedure catheter. The method further includes proximally removing the access catheter and performing a neurovascular procedure using the procedure catheter.

Abstract: A method of priming an interventional device assembly includes providing the interventional device assembly including a first interventional device coupled to a first hub and a second interventional device coupled to a second hub arranged in a concentric stack, the second interventional device being positioned within a lumen of the first interventional device. The method includes coupling the interventional device assembly to a drive system while arranged in the concentric stack, axially advancing the first interventional device and the first hub relative to the second hub to decrease a depth of insertion of the second interventional device within the lumen of the first interventional device while maintaining a distal end of the second interventional device within the lumen of the first interventional device, and flushing the first interventional device with fluid after decreasing the depth of insertion of the second interventional device within the lumen of the first interventional device.

Abstract: A drive system for achieving supra-aortic access and neurovascular treatment site access includes a guidewire hub configured to adjust an axial position and a rotational position of a guidewire, a procedure catheter hub configured to adjust an axial position and a rotational position of a procedure catheter, a guide catheter hub configured to adjust an axial position of a guide catheter, and an access catheter hub configured to adjust an axial position and a rotational position of an access catheter, the access catheter further configured to laterally deflect a distal deflection zone of the access catheter.

Abstract: A method of priming an interventional device assembly includes providing the interventional device assembly, the interventional device assembly including a first interventional device and a second interventional device, the second interventional device being positioned within the first interventional device. The method further includes reciprocally moving at least one of the first interventional device and the second interventional device relative to the other of the first interventional device and the second interventional device while flushing a lumen between the first interventional device and the second interventional device with fluid to remove microbubbles from the lumen.

Abstract: A method of performing a neurovascular procedure includes providing an assembly including a guidewire having a guidewire hub, an access catheter having an access catheter hub, and a guide catheter having a guide catheter hub. The method includes coupling the guidewire hub to a first hub adapter, coupling the access catheter hub to a second hub adapter, and coupling the guide catheter hub to a third hub adapter. Each of the first hub adapter, the second hub adapter and the third hub adapter is movably carried by a support table. The method includes driving the assembly in response to movement of each of the first hub adapter, the second hub adapter and the third hub adapter along the support table until the assembly is positioned to achieve supra-aortic vessel access.

Abstract: A robotically driven interventional device includes an elongate, flexible body, having a proximal end and a distal end; a hub on the proximal end; at least one rotatable roller on a first surface of the hub; and at least one magnet on the first surface of the hub.

Abstract: A method of performing a neurovascular procedure includes the steps of providing an access catheter having an access catheter hub; coupling the access catheter hub to a hub adapter, movably carried by a support table; driving the access catheter in response to movement of the hub adapter along the table until the access catheter is positioned to achieve supra-aortic vessel access; removing the access catheter and access catheter hub from the hub adapter; and coupling a procedure catheter hub having a procedure catheter to the hub adapter.

Abstract: A sterile packaging assembly for transporting interventional devices to a robotic surgery site includes a sterile barrier having a hub support portion and configured to enclose a sterile volume; and at least a first interventional device within the sterile volume. The first interventional device includes a hub and an elongate flexible body. The hub includes at least one magnet and at least one roller configured to roll on the hub support portion of the sterile barrier.

Abstract: A method of performing a neurovascular procedure includes the steps of providing an access assembly comprising a guidewire, access catheter and guide catheter; coupling the access assembly to a robotic drive system; and driving the access assembly to achieve supra-aortic vessel access. The guide wire and the access catheter are decoupled from the access assembly. A procedure assembly includes at least a guidewire and a procedure catheter. The procedure assembly is coupled to the robotic drive system; and used to perform a neurovascular procedure.

Abstract: A supra-aortic vessel access robotic control system includes a guidewire hub configured to adjust each of an axial position and a rotational position of a guidewire; a guide catheter hub configured to adjust a guide catheter in an axial direction; and a procedure catheter hub configured to adjust each of an axial position and a rotational position of a procedure catheter, and also to laterally deflect a distal deflection zone of the procedure catheter.

Abstract: Endobronchial methods, devices and systems for treating emphysema by creating an airway bypass in a patient's airway including a longitudinal fenestration held open by an airway expander.

Abstract: A flow control device (241, 260, 300, 350, 450, 480, 500) for a bronchial passageway including: a one-way valve (273, 313, 360, 478, 511); a hollow structural frame (242, 302, 352, 453, 468, 509) housing the one-way valve, wherein the structural frame is expandable from a collapsed configuration to an expanded configuration; and a sealing membrane (316, 470, 512) mounted to at least a distal portion of the structural frame, wherein the sealing membrane forms an enclosed wall defining at least a portion of an airflow passage through the flow control device, and the one-way valve is included in the airflow passage.

Abstract: Systems and methods for remotely monitoring blood flow that include an endovascular prosthesis. The endovascular prosthesis includes a conduit forming a lumen within a surrounding wall having an inner surface and an outer surface. A monitoring device is disposed on the wall forming the lumen. The monitoring device comprises a sensor element configured to detect a physical event and to generate an electrical parameter shift in response to the physical event. An antenna portion is configured to receive a first oscillating electrical signal from an interrogator device and to transmit a second oscillating electrical signal to the interrogator device. The second oscillating electrical signal is modulated by the electrical parameter shift.

Abstract: An endovascular prosthesis comprising: a conduit formed by a wall structure surrounding a lumen; a sensor element configured to generate an electrical parameter shift in response to a physical event, the sensor element integrated in the wall structure of the conduit, the wall structure includes at least one wire structure, where at least a part of the wire structure include a first metallic conduit, a second metallic conduit, and a sensor disposed between the first metallic conduit and the second metallic conduit, where the first and second metallic conduits are conductors in a monitoring device detecting the electrical parameter shift in the sensor; wherein the sensor is either a variable capacitive sensor, and the first metallic conduit and the second metallic conduit form the electrodes of the variable capacitor; or a variable resistor configured to generate a resistance change in response to the physical event.

Abstract: Systems and methods for remotely monitoring blood flow that include an endovascular prosthesis. The endovascular prosthesis includes a conduit forming a lumen within a surrounding wall having an inner surface and an outer surface. A monitoring device is disposed on the wall forming the lumen. The monitoring device comprises a sensor element configured to detect a physical event and to generate an electrical parameter shift in response to the physical event. An antenna portion is configured to receive a first oscillating electrical signal from an interrogator device and to transmit a second oscillating electrical signal to the interrogator device. The second oscillating electrical signal is modulated by the electrical parameter shift.

Abstract: Methods of treating COPD, including bronchoscopically positioning a lung anchor in lung tissue, positioning an outer implant member in pleural space proximate the lung anchor, and coupling the lung anchor to the outer implant member and thereby compressing lung tissue.

Abstract: Methods, devices, and systems for mechanically reducing the volume of the lung. Some embodiments include endobronchially positioning an anchoring device within a lung, the anchoring device comprising at least a distal anchor, expanding at least a portion of the distal anchor to anchor the distal anchor against lung lumen tissue, and tensioning at least a portion of the device to reduce the volume of the lung.