Patents by Inventor Lillian Ye

Lillian Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STEM CELL DERIVED ISLET DIFFERENTIATION
    Publication number: 20230085395
    Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.
    Type: Application
    Filed: November 14, 2022
    Publication date: March 16, 2023
    Inventors: Felicia J. PAGLIUCA, George HARB, Lillian YE
  • STEM CELL DERIVED ISLET DIFFERENTIATION
    Publication number: 20230075375
    Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.
    Type: Application
    Filed: November 14, 2022
    Publication date: March 9, 2023
    Inventors: Felicia J. PAGLIUCA, George HARB, Lillian YE
  • Stem cell derived islet differentiation
    Patent number: 11525120
    Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: December 13, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Felicia J. Pagliuca, George Harb, Lillian Ye
  • Stem cell derived islet differentiation
    Patent number: 11466256
    Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: October 11, 2022
    Assignee: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Felicia J. Pagliuca, George Harb, Lillian Ye
  • PANCREATIC DIFFERENTIATION
    Publication number: 20220235327
    Abstract: In some aspects, disclosed herein are methods and compositions for generating enterochromaffin cells. In some aspects, the methods and compositions disclosed herein relate to use of an inhibitor of IL-4/JAK3 signaling pathway. In other aspects, disclosed herein are cell compositions, pharmaceutical compositions, and medical devices that relate to pancreatic cells that are generated according to the methods disclosed herein.
    Type: Application
    Filed: February 11, 2022
    Publication date: July 28, 2022
    Inventors: George HARB, Lillian YE
  • STEM CELL DERIVED ISLET DIFFERENTIATION
    Publication number: 20210403875
    Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Inventors: Felicia J. Pagliuca, George Harb, Lillian Ye
  • STEM CELL DERIVED ISLET DIFFERENTIATION
    Publication number: 20210403876
    Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Inventors: Felicia J. Pagliuca, George Harb, Lillian Ye
  • STEM CELL DERIVED ISLET DIFFERENTIATION
    Publication number: 20210238553
    Abstract: Provided herein are methods of producing ? cells and precursors thereof utilizing a Wnt signaling inhibitor or PKC activator, or both. Also provided herein are in vitro cultures comprising said cells, methods of treating a subject with a disease characterized by high blood sugar levels over a prolonged period of time by administering said cells, and devices for encapsulating said cells.
    Type: Application
    Filed: February 9, 2021
    Publication date: August 5, 2021
    Inventors: Felicia J. Pagliuca, George Harb, Lillian Ye
  • METHODS OF ENHANCING STEM CELL DIFFERENTIATION INTO BETA CELLS
    Publication number: 20210198632
    Abstract: Disclosed herein are compositions and methods of enhancing stem cell differentiation into beta cells with use of one or more epigenetic modification compounds. The present disclosure also relates to compositions and methods of sorting and enriching the differentiated beta cells. The present disclosure also relates to compositions and methods of irradiating cell population for reducing proliferation.
    Type: Application
    Filed: September 2, 2020
    Publication date: July 1, 2021
    Inventors: Felicia Pagliuca, George Harb, Mads Gurtler, Jason Gaglia, Yeh-Chuin Poh, Lillian Ye, Austin Thiel, Jihad Yasin, Evrett Thompson