Patents by Inventor Lily Y. T. Li

Lily Y. T. Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • QUANTIFICATION OF TRANSTHYRETIN AND ITS ISOFORMS
    Publication number: 20200088746
    Abstract: The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.
    Type: Application
    Filed: April 25, 2019
    Publication date: March 19, 2020
    Inventors: James Butler, Renta Hutabarat, Rene Alvarez, Bob Xiong, Lily Y.T. Li
  • METHOD FOR DETERMINING THE IN VIVO COMPARABILITY OF A BIOLOGIC DRUG AND A REFERENCE DRUG
    Publication number: 20190073452
    Abstract: The invention provides a mass-spectroscopic approach for assessing and determining the in vivo comparability of a candidate biologic molecule to a reference biologic molecule. The results can be presented in the form of an in vivo comparability profile, which can serve as a development tool, e.g., as a guide or target for the development of biologies, biosimilars, or gene therapy-based drugs. The invention further provides an approach using an in vivo comparability profile for measuring the similarity of two biologies, for example, a biosimilar and a reference approved biologic or manufacturing lots of the same biologic to confirm acceptable release criteria for a particular manufacturing lot.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 7, 2019
    Applicant: BIOANALYTIX, Inc.
    Inventors: Lily Y.T. Li, Kirtland G. Poss, Shiaw-Lin Wu, Robert Garnick
  • QUANTIFICATION OF TRANSTHYRETIN AND ITS ISOFORMS
    Publication number: 20170045536
    Abstract: The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.
    Type: Application
    Filed: October 28, 2016
    Publication date: February 16, 2017
    Inventors: James Butler, Renta Hutabarat, Rene Alvarez, Bob Xiong, Lily Y.T. Li
  • QUANTIFICATION OF TRANSTHYRETIN AND ITS ISOFORMS
    Publication number: 20140315231
    Abstract: The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.
    Type: Application
    Filed: November 16, 2012
    Publication date: October 23, 2014
    Inventors: James Butler, Renta Hutabarat, Rene Alvarez, Bob Xiong, Lily Y.T. Li
  • Generation of efficacy, toxicity and disease signatures and methods of use thereof
    Publication number: 20040121305
    Abstract: The invention provides methods of generating small molecule efficacy profiles and signature, small molecule toxicity profiles and signatures and small molecule disease profiles and signatures. The invention also provides methods of determining the efficacy and/or toxicity of unknown agents and drugs in a subject and methods of diagnosing an unknown disease or disorder in a subject. The invention further provides methods of monitoring the progression or remission of a disease or disorder in a subject undergoing treatment and methods of measuring the effectiveness of treatment.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: Roger Charles Wiegand, Robert Michael McCarroll, Lily Y. T. Li, Dong Wei, Merce Crosas, James Anthony Rogers, Alexander Frederic Rosenberg