Patents by Inventor Lim Wong

Lim Wong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240368302
    Abstract: The application relates to the technical field of antibody drugs and provided are a group of sequences encoding a specific single-domain antibody for TROP2 and the use thereof. The provided anti-TROP2 single-domain antibody can effectively bind to a TROP2 antigen, and provides a basis for research and development of drugs targeting TROP2, including a nuclide-drug conjugate, an antibody-drug conjugate, a multispecific antibody drug, etc.
    Type: Application
    Filed: June 30, 2022
    Publication date: November 7, 2024
    Inventors: Chung Lim WONG, Hong Hoi TING
  • Publication number: 20240360248
    Abstract: Provided are a set of specific single-domain antibody coding sequences targeting PTK7 and an application thereof. The provided anti-PTK7 single-domain antibody may effectively bind to a PTK7 antigen, which provides a basis for the research and development of drugs targeting PTK7, including radionuclide drug conjugates, antibody drug conjugates, multispecific antibody drugs and so on.
    Type: Application
    Filed: August 17, 2022
    Publication date: October 31, 2024
    Inventors: Chung Lim WONG, Hong Hoi TING
  • Patent number: 12083193
    Abstract: Provided are an anti-Her2 nanobody and a coding sequence and the use thereof. In particular, provided is a nanobody combating human epidermal growth factor receptor-2 (Her2/ERBB2). Disclosed are the nanobody and the a gene sequence encoding the nanobody, a corresponding expression vector and a host cell capable of expressing the nanobody, and a method for producing the nanobody of the present invention and the related use thereof. The present invention may also provide an immunoconjugate of the nanobody and the use thereof, especially the use in the diagnosis and treatment of Her2 positive tumor.
    Type: Grant
    Filed: October 18, 2022
    Date of Patent: September 10, 2024
    Assignee: NANOMAB TECHNOLOGY LIMITED
    Inventors: Hong Hoi Ting, Chung Lim Wong, Wenhua Huang
  • Publication number: 20230263916
    Abstract: Provided are an anti-Her2 nanobody and a coding sequence and the use thereof. In particular, provided is a nanobody combating human epidermal growth factor receptor-2 (Her2/ERBB2). Disclosed are the nanobody and the a gene sequence encoding the nanobody, a corresponding expression vector and a host cell capable of expressing the nanobody, and a method for producing the nanobody of the present invention and the related use thereof. The present invention may also provide an immunoconjugate of the nanobody and the use thereof, especially the use in the diagnosis and treatment of Her2 positive tumor.
    Type: Application
    Filed: October 18, 2022
    Publication date: August 24, 2023
    Inventors: Hong Hoi Ting, Chung Lim Wong, Wenhua Huang
  • Patent number: 11642418
    Abstract: Disclosed is the use of a radiolabeled anti-nanobody in the prognosis and diagnosis of cancers. In particular, disclosed is an immunoconjugate for detecting a PD-L1 molecule. The immunoconjugate comprises the VHH chain of a specific anti-PD-L1 nanobody and a radionuclide, and can be used for non-invasive detecting of expression of the object PD-L1 to be detected. The immunoconjugate of the invention has small size and high specificity, and is suitable for systemic detection which simultaneously targets primary and metastatic tumors, and has high accuracy and low radiation dose.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: May 9, 2023
    Assignee: NANOMAB TECHNOLOGY LIMITED
    Inventors: Hong Hoi Ting, Chung Lim Wong
  • Patent number: 11517632
    Abstract: Provided are an anti-Her2 nanobody and a coding sequence and the use thereof. In particular, provided is a nanobody combating human epidermal growth factor receptor-2 (Her2/ERBB2). Disclosed are the nanobody and the a gene sequence encoding the nanobody, a corresponding expression vector and a host cell capable of expressing the nanobody, and a method for producing the nanobody of the present invention and the related use thereof. The present invention may also provide an immunoconjugate of the nanobody and the use thereof, especially the use in the diagnosis and treatment of Her2 positive tumor.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: December 6, 2022
    Assignee: NANOMAB TECHNOLOGY LIMITED
    Inventors: Hong Hoi Ting, Chung Lim Wong, Wenhua Huang
  • Patent number: 11466085
    Abstract: Provided in the present invention are a type of anti-human PD-L1 specific nanobodies and VHH chains thereof, coding sequences of the foregoing nanobodies or VHH chains thereof, corresponding expression vectors and host cells, and a method for producing antibodies.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: October 11, 2022
    Assignee: NANOMAB TECHNOLOGY LIMITED
    Inventors: Hong Hoi Ting, Chung Lim Wong
  • Publication number: 20200306392
    Abstract: Provided are an anti-Her2 nanobody and a coding sequence and the use thereof. In particular, provided is a nanobody combating human epidermal growth factor receptor-2 (Her2/ERBB2). Disclosed are the nanobody and the a gene sequence encoding the nanobody, a corresponding expression vector and a host cell capable of expressing the nanobody, and a method for producing the nanobody of the present invention and the related use thereof. The present invention may also provide an immunoconjugate of the nanobody and the use thereof, especially the use in the diagnosis and treatment of Her2 positive tumor.
    Type: Application
    Filed: June 20, 2018
    Publication date: October 1, 2020
    Applicant: NANOMAB TECHNOLOGY LIMITED
    Inventors: Hong Hoi Ting, Chung Lim Wong, Wenhua Huang
  • Publication number: 20200276330
    Abstract: Disclosed is the use of a radiolabeled anti-nanobody in the prognosis and diagnosis of cancers. In particular, disclosed is an immunoconjugate for detecting a PD-L1 molecule. The immunoconjugate comprises the VHH chain of a specific anti-PD-L1 nanobody and a radionuclide, and can be used for non-invasive detecting of expression of the object PD-L1 to be detected. The immunoconjugate of the invention has small size and high specificity, and is suitable for systemic detection which simultaneously targets primary and metastatic tumors, and has high accuracy and low radiation dose.
    Type: Application
    Filed: September 13, 2018
    Publication date: September 3, 2020
    Inventors: Hong Hoi TING, Chung Lim WONG
  • Publication number: 20200148772
    Abstract: Provided in the present invention are a type of anti-human PD-L1 specific nanobodies and VHH chains thereof, coding sequences of the foregoing nanobodies or VHH chains thereof, corresponding expression vectors and host cells, and a method for producing antibodies.
    Type: Application
    Filed: December 20, 2019
    Publication date: May 14, 2020
    Inventors: Hong Hoi Ting, Chung Lim Wong
  • Patent number: 10556954
    Abstract: Provided in the present invention are a type of anti-human PD-L1 specific nanobodies and VHH chains thereof, coding sequences of the foregoing nanobodies or VHH chains thereof, corresponding expression vectors and host cells, and a method for producing antibodies.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: February 11, 2020
    Assignee: NANOMAB TECHNOLOGY LIMITED
    Inventors: Hong Hoi Ting, Chung Lim Wong
  • Publication number: 20190177416
    Abstract: Provided in the present invention are a type of anti-human PD-L1 specific nanobodies and VHH chains thereof, coding sequences of the foregoing nanobodies or VHH chains thereof, corresponding expression vectors and host cells, and a method for producing antibodies.
    Type: Application
    Filed: March 17, 2017
    Publication date: June 13, 2019
    Inventors: Hong Hoi Ting, Chung Lim Wong
  • Patent number: 9104383
    Abstract: A programmable logic controller (PLC) assembly includes a bottom housing with a base, a first plurality of elongate alignment features extending from the bottom housing transverse to the base, and a first connection feature. The PLC assembly includes a central processing unit with a circuit board and at least two receptacles therethrough configured to engage and slide along at least two of the first plurality of alignment features. The at least two of the first plurality of alignment features are positioned asymmetrically with respect to the base. The PLC assembly includes an upper housing with a second connection feature configured to slidably couple with the first connection feature and a second plurality of elongate alignment features configured to slidably engage at least two of the first plurality of alignment features, which are positioned asymmetrically with respect to the base.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: August 11, 2015
    Assignee: Rockwell Automation Technologies, Inc.
    Inventors: Karen Chin, Chee Lim Wong
  • Patent number: 9007752
    Abstract: An interlocking system for connecting a programmable logic controller and a power supply of an industrial control and automation system is provided. The interlocking system includes features configured to facilitate coupling with a panel or rail and a plurality of vertical slots and a latch disposed on a side surface of the power supply. The latch includes a first attachment feature disposed along a flexible tongue cantilevered proximate an opening in a housing of the power supply such that the tongue can flex into the opening. The interlocking system also includes a plurality of hooks and a second attachment feature formed on a side surface of the programmable logic controller.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: April 14, 2015
    Assignee: Rockwell Automation Asia Pacific Business Center Pte. Ltd.
    Inventors: Karen Chin, Chee Lim Wong
  • Publication number: 20150029662
    Abstract: A programmable logic controller (PLC) assembly includes a bottom housing with a base, a first plurality of elongate alignment features extending from the bottom housing transverse to the base, and a first connection feature. The PLC assembly includes a central processing unit with a circuit board and at least two receptacles therethrough configured to engage and slide along at least two of the first plurality of alignment features. The at least two of the first plurality of alignment features are positioned asymmetrically with respect to the base. The PLC assembly includes an upper housing with a second connection feature configured to slidably couple with the first connection feature and a second plurality of elongate alignment features configured to slidably engage at least two of the first plurality of alignment features, which are positioned asymmetrically with respect to the base.
    Type: Application
    Filed: October 14, 2014
    Publication date: January 29, 2015
    Inventors: Karen Chin, Chee Lim Wong
  • Patent number: 8902598
    Abstract: A programmable logic controller (PLC) assembly includes a bottom housing with a base, a first plurality of elongate alignment features extending from the bottom housing transverse to the base, and a first connection feature. The PLC assembly includes a central processing unit with a circuit board and at least two receptacles therethrough configured to engage and slide along at least two of the first plurality of alignment features. The at least two of the first plurality of alignment features are positioned asymmetrically with respect to the base. The PLC assembly includes an upper housing with a second connection feature configured to slidably couple with the first connection feature and a second plurality of elongate alignment features configured to slidably engage at least two of the first plurality of alignment features, which are positioned asymmetrically with respect to the base.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: December 2, 2014
    Assignee: Rockwell Automation Technologies, Inc.
    Inventors: Karen Chin, Chee Lim Wong
  • Publication number: 20140098477
    Abstract: An interlocking system for connecting a programmable logic controller and a power supply of an industrial control and automation system is provided. The interlocking system includes features configured to facilitate coupling with a panel or rail and a plurality of vertical slots and a latch disposed on a side surface of the power supply. The latch includes a first attachment feature disposed along a flexible tongue cantilevered proximate an opening in a housing of the power supply such that the tongue can flex into the opening. The interlocking system also includes a plurality of hooks and a second attachment feature formed on a side surface of the programmable logic controller.
    Type: Application
    Filed: December 6, 2013
    Publication date: April 10, 2014
    Applicant: ROCKWELL AUTOMATION ASIA PACIFIC BUSINESS CENTER PTE. LTD.
    Inventors: Karen Chin, Chee Lim Wong
  • Patent number: 8625261
    Abstract: An interlocking system for connecting a programmable logic controller and a power supply of an industrial control and automation system is provided. The interlocking system includes features configured to facilitate coupling with a panel or rail and a plurality of vertical slots and a latch disposed on a side surface of the power supply. The latch includes a first attachment feature disposed along a flexible tongue cantilevered proximate an opening in a housing of the power supply such that the tongue can flex into the opening. The interlocking system also includes a plurality of hooks and a second attachment feature formed on a side surface of the programmable logic controller.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: January 7, 2014
    Assignee: Rockwell Automation Technologies, Inc.
    Inventors: Karen Chin, Chee Lim Wong
  • Patent number: D660806
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: May 29, 2012
    Assignee: Rockwell Automation Technologies, Inc.
    Inventor: Chee Lim Wong
  • Patent number: D661656
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: June 12, 2012
    Assignee: Rockwell Automation Technologies, Inc.
    Inventors: Douglas R. Bodmann, Chee Lim Wong