Abstract: Provided herein are acyclic oxazepinyl compounds useful in the treatment on cancers.

Abstract: The present invention relates to an aqueous polyurethane urea dispersion containing a polyurethane urea and a preparation process and use thereof, especially to the use in the field of coatings, adhesives or sealants, and the products obtained by coating, bonding or sealing with the polyurethane urea dispersion. The polyurethane urea of the aqueous polyurethane urea dispersion containing the polyurethane urea is obtained by the reaction of a system including the following components: a mixture of isocyanates, a polymer polyol, a monofunctional nonionic hydrophilic compound and a potentially anionic or anionic hydrophilic compound; said aqueous polyurethane urea dispersion has a viscosity of 5 s-18 s; relative to the total weight of said aqueous polyurethane urea dispersion, the amount of said polyurethane urea is 30 wt %-50 wt %. The aqueous polyurethane urea dispersion of the present invention has good compatibility with various organic solvents.

Abstract: The present invention relates to a two-component system comprising a component A) comprising at least one polymeric polyol which has an OH content of ?4.5 wt %, based on the total solids content of the polymeric polyol, and a component B) comprising at least one polyisocyanate which has a number average isocyanate group functionality of ?4.0 to ?10.0, based on the total solids content of the polyisocyanate, a fraction of ?25 wt %, based on the total solids content of the polyisocyanate, of oligomers containing isocyanate groups and having a number-average molecular weight of ?780 g/mol, and an isocyanurate group fraction of ?5 mol % to ?70 mol %, based on the total amount of isocyanurate groups and allophanate groups in the polyisocyanate. The invention further relates to a method for producing a coating on a substrate, to the coating obtainable by this method, and to the coated substrate.

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: Provided herein are tetracyclic oxazepinyl compounds useful in the treatment on cancers.

Abstract: Compounds of Formula (IA), or a pharmaceutically acceptable salt thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: The present invention relates to a two-component system comprising a component A) comprising at least one polymeric polyol which has an OH content of ?4.5 wt %, based on the total solids content of the polymeric polyol, and a component B) comprising at least one polyisocyanate which has a number average isocyanate group functionality of ?4.0 to ?10.0, based on the total solids content of the polyisocyanate, a fraction of ?25 wt %, based on the total solids content of the polyisocyanate, of oligomers containing isocyanate groups and having a number-average molecular weight of ?780 g/mol, and an isocyanurate group fraction of ?5 mol % to ?70 mol %, based on the total amount of isocyanurate groups and allophanate groups in the polyisocyanate. The invention further relates to a method for producing a coating on a substrate, to the coating obtainable by this method, and to the coated substrate.

Abstract: Compounds of Formula (IA), or a pharmaceutically acceptable salt thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: Compounds of Formula (I) and (II), or a stereoisomer, tautomer, solvate, prodrug or salt thereof, and methods of use as Janus kinase inhibitors are described herein.

Abstract: A silty floating mud collection device, which includes a drive cylinder, an outer sleeve, a sampler barrel, an lug cover plate, a turning cover, a control ring and a control rod, where the drive cylinder includes a cylinder liner, a piston and a piston rod; the outer sleeve is fixedly connected below the cylinder liner; the sampler barrel is detachably installed inside the outer sleeve; the lug cover plate is fixedly connected to a lower end of the piston rod, and can close an upper-end opening of the sampler barrel; the turning cover is turnably installed at a lower end of the outer sleeve, and can close a lower-end opening of the sampler barrel; the control ring is located below the sampler barrel, and is used to block the turning cover which is in an open state; and an upper end of the control rod is connected to the lug cover plate, and a lower end of the control rod is connected to the control ring.

Abstract: A silty floating mud collection device, which includes a drive cylinder, an outer sleeve, a sampler barrel, an lug cover plate, a turning cover, a control ring and a control rod, where the drive cylinder includes a cylinder liner, a piston and a piston rod; the outer sleeve is fixedly connected below the cylinder liner; the sampler barrel is detachably installed inside the outer sleeve; the lug cover plate is fixedly connected to a lower end of the piston rod, and can close an upper-end opening of the sampler barrel; the turning cover is turnably installed at a lower end of the outer sleeve, and can close a lower-end opening of the sampler barrel; the control ring is located below the sampler barrel, and is used to block the turning cover which is in an open state; and an upper end of the control rod is connected to the lug cover plate, and a lower end of the control rod is connected to the control ring.

Abstract: Method and system of processing cross-domain cookies in order to allow a first website to access a cookie of a second website are provided. In one aspect, a method includes: providing a flash cookie of a first website in a user's local computer; reading an ordinary cookie of a second website that is stored in the user's local computer; and writing the ordinary cookie of the second website into the flash cookie of the first website. Based on this method, it is achievable to access and store cookies across domains in the user's local computer. Accordingly, the method enables e-commerce websites to have a more comprehensive collection of user information to provide more reliable references for the e-commerce websites to analyze user information.

Abstract: Method and system of processing cross-domain cookies in order to allow a first website to access a cookie of a second website are provided. In one aspect, a method includes: providing a flash cookie of a first website in a user's local computer; reading an ordinary cookie of a second website that is stored in the user's local computer; and writing the ordinary cookie of the second website into the flash cookie of the first website. Based on this method, it is achievable to access and store cookies across domains in the user's local computer. Accordingly, the method enables e-commerce websites to have a more comprehensive collection of user information to provide more reliable references for the e-commerce websites to analyze user information.