Patents by Inventor Limin Shang

Limin Shang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240254223
    Abstract: Described herein are compositions and methods to produce masked antibodies useful in a variety of therapeutic indications.
    Type: Application
    Filed: September 1, 2023
    Publication date: August 1, 2024
    Inventors: Limin SHANG, Giovanni MAGISTRELLI, Nicolas FISCHER, Elise Sylvie Blanche LECHINE, Pauline MALINGE
  • Publication number: 20240254234
    Abstract: The present invention relates to PD-L1xCD28 bispecific antibodies which act as immune checkpoint inhibitors by binding to and blocking PD-L1 (thus preventing its engagement with PD-1 expressed on T cells) that can further deliver a costimulatory signal to T cells by clustering and agonistically engaging CD28.
    Type: Application
    Filed: October 20, 2023
    Publication date: August 1, 2024
    Inventors: Sara MAJOCCHI, Valéry MOINE, Krzysztof M. MASTERNAK, Limin SHANG, Walter FERLIN
  • Patent number: 11969751
    Abstract: The present disclosure provides a method and system by which a precise amount of a viscous fluid sealing compound can be dispensed at required locations through computer vision-based observation of the fluid deposited, its rate and amount of deposition and location; and that the dispensed fluid may be accurately shaped through robotic or other special purpose mechanism motion. The invention enables instant quality inspection of the dispensing process in terms of the locations, amounts and shapes of newly created seals.
    Type: Grant
    Filed: September 29, 2021
    Date of Patent: April 30, 2024
    Assignee: MACDONALD, DETTWILER AND ASSOCIATES INC.
    Inventors: Limin Shang, Adam Neil Philip, Piotr Jasiobedzki, Mark Patrick Barnet, Timothy Reedman
  • Publication number: 20240002544
    Abstract: The present invention relates to antibody arms which bind agonistically to human CD28. The present invention relates to bispecific antibodies which bind to human carcinoembryonic antigen (CEA) and human CD28 using the agonist anti-CD28 arms described herein. The present invention relates to bispecific antibodies which bind to human mesothelin (MSLN) and human CD28 using the agonist anti-CD28 arms described herein.
    Type: Application
    Filed: March 7, 2023
    Publication date: January 4, 2024
    Inventors: Sara MAJOCCHI, Krzysztof MASTERNAK, Limin SHANG, Nicolas FISCHER, Xavier CHAUCHET
  • Publication number: 20230295348
    Abstract: The present disclosure provides compositions of bispecific antibodies useful in selective cytokine activation on immune cells. The present disclosure also provides compositions of bispecific antibodies useful for treatment of cancers that express tumor associated antigens.
    Type: Application
    Filed: January 24, 2023
    Publication date: September 21, 2023
    Inventors: Nicolas FISCHER, Julien MONTORFANI, Limin SHANG, Eric HATTERER
  • Publication number: 20220315655
    Abstract: This disclosure provides novel bispecific antibodies that specifically bind to CD47 and Programmed Death-Ligand 1 (PD-L1). The disclosure further relates to methods of making the bispecific antibodies and nucleic acids encoding the antibodies. The disclosure further relates to therapeutic methods for use of the bispecific antibodies in the treatment of a condition associated with malignant cells expressing CD47 and/or PD-L1 (e.g. cancer).
    Type: Application
    Filed: March 22, 2022
    Publication date: October 6, 2022
    Inventors: Xavier CHAUCHET, Krzysztof MASTERNAK, Limin SHANG, Giovanni MAGISTRELLI, Nicolas FISCHER
  • Publication number: 20220315654
    Abstract: This disclosure provides novel bispecific antibodies that specifically bind to CD47 and Programmed Death-Ligand 1 (PD-L1). The disclosure further relates to methods of making the bispecific antibodies and nucleic acids encoding the antibodies. The disclosure further relates to therapeutic methods for use of the bispecific antibodies in the treatment of a condition associated with malignant cells expressing CD47 and/or PD-L1 (e.g. cancer).
    Type: Application
    Filed: March 22, 2022
    Publication date: October 6, 2022
    Inventors: Xavier CHAUCHET, Krzysztof MASTERNAK, Limin SHANG, Elise PENARRIETA, Walter FERLIN
  • Publication number: 20220080454
    Abstract: The present disclosure provides a method and system by which a precise amount of a viscous fluid sealing compound can be dispensed at required locations through computer vision-based observation of the fluid deposited, its rate and amount of deposition and location; and that the dispensed fluid may be accurately shaped through robotic or other special purpose mechanism motion. The invention enables instant quality inspection of the dispensing process in terms of the locations, amounts and shapes of newly created seals.
    Type: Application
    Filed: September 28, 2021
    Publication date: March 17, 2022
    Inventors: Limin Shang, Adam Neil Philip, Piotr Jasiobedzki, Mark Patrick Barnet, Timothy Reedman
  • Publication number: 20220016669
    Abstract: The present disclosure provides a method and system by which a precise amount of a viscous fluid sealing compound can be dispensed at required locations through computer vision-based observation of the fluid deposited, its rate and amount of deposition and location; and that the dispensed fluid may be accurately shaped through robotic or other special purpose mechanism motion. The invention enables instant quality inspection of the dispensing process in terms of the locations, amounts and shapes of newly created seals.
    Type: Application
    Filed: September 29, 2021
    Publication date: January 20, 2022
    Inventors: Limin Shang, Adam Neil Philip, Piotr Jasiobedzki, Mark Patrick Barnet, Timothy Reedman
  • Patent number: 11192137
    Abstract: The present disclosure provides a method and system by which a precise amount of a viscous fluid sealing compound can be dispensed at required locations through computer vision-based observation of the fluid deposited, its rate and amount of deposition and location; and that the dispensed fluid may be accurately shaped through robotic or other special purpose mechanism motion. The invention enables instant quality inspection of the dispensing process in terms of the locations, amounts and shapes of newly created seals.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: December 7, 2021
    Assignee: MacDonald, Dettwiler and Associates Inc.
    Inventors: Limin Shang, Adam Neil Philip, Piotr Jasiobedzki, Mark Patrick Barnet, Timothy Reedman
  • Patent number: 10776947
    Abstract: The present invention provides a method, a system and an equipment for automatically detecting and tracking a blade, used for tracking the blade of the wind power generator through an unmanned aerial vehicle. The unmanned aerial vehicle is provided with a cradle head, the cradle head controls a shooting angle of a camera, including the following steps: acquiring a blade video file through a camera, detecting at least one frame of the blade image in the blade video file, and extracting side edges of the blade region in the at least one frame of blade images; tracking and detecting the side edges of the blade region in temporally adjacent multi-frame blade images in the blade video file according to the side edges of the blade region; determining a center point of the blade region in each frame of the blade image; and adjusting the cradle head.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: September 15, 2020
    Inventors: Xun Liu, Limin Shang, Xiaoming Chen, Hua Ye, Yan Ke
  • Patent number: 10689441
    Abstract: This invention relates generally to anti-Toll-like Receptor 4 (TLR4 antagonists) including antibodies that specifically bind Toll-like Receptor 4 (TLR-4), to methods of using the anti-TLR4 antagonists as therapeutics and to methods of using the anti-TLR4 antagonists for inhibiting, delaying the progression of, or otherwise ameliorating a symptom of Graft-versus-Host disease (GvHD) and/or improving survival of GvHD subjects and/or transplanted biological materials in subjects.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: June 23, 2020
    Assignee: NovImmune SA
    Inventors: Emmanuel Monnet, Limin Shang, Susana Salgado-Pires, Walter Ferlin, Greg Elson
  • Patent number: 10556960
    Abstract: This invention relates generally to methods and compositions for diagnosing and treating disorders associated with elevated levels of Toll-like Receptor 4 (TLR4) ligands and other biomarkers. The invention also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder associated with elevated levels of TLR4 ligands and other biomarkers using agents that interfere with or otherwise antagonize TLR4 signaling, including neutralizing anti-TLR4 antibodies.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: February 11, 2020
    Assignee: NovImmune SA
    Inventors: Cristina de Min, Limin Shang, Emmanuel Monnet, Greg Elson, Eric Hatterer
  • Publication number: 20190370999
    Abstract: The present invention provides a method, a system and an equipment for automatically detecting and tracking a blade, used for tracking the blade of the wind power generator through an unmanned aerial vehicle. The unmanned aerial vehicle is provided with a cradle head, the cradle head controls a shooting angle of a camera, including the following steps: acquiring a blade video file through a camera, detecting at least one frame of the blade image in the blade video file, and extracting side edges of the blade region in the at least one frame of blade images; tracking and detecting the side edges of the blade region in temporally adjacent multi-frame blade images in the blade video file according to the side edges of the blade region; determining a center point of the blade region in each frame of the blade image; and adjusting the cradle head.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 5, 2019
    Applicant: Shanghai Clobotics Technology Co., Ltd.
    Inventors: Xun LIU, Limin SHANG, Xiaoming CHEN, Hua YE, Yan KE
  • Publication number: 20180009000
    Abstract: The present disclosure provides a method and system by which a precise amount of a viscous fluid sealing compound can be dispensed at required locations through computer vision-based observation of the fluid deposited, its rate and amount of deposition and location; and that the dispensed fluid may be accurately shaped through robotic or other special purpose mechanism motion. The invention enables instant quality inspection of the dispensing process in terms of the locations, amounts and shapes of newly created seals.
    Type: Application
    Filed: July 10, 2017
    Publication date: January 11, 2018
    Inventors: Limin Shang, Adam Neil Philip, Piotr Jasiobedzki, Mark Patrick Barnet, Timothy Reedman
  • Publication number: 20170298140
    Abstract: This invention relates generally to methods and compositions for diagnosing and treating disorders associated with elevated levels of Toll-like Receptor 4 (TLR4) ligands and other biomarkers. The invention also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder associated with elevated levels of TLR4 ligands and other biomarkers using agents that interfere with or otherwise antagonize TLR4 signaling, including neutralizing anti-TLR4 antibodies.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 19, 2017
    Inventors: Cristina de Min, Limin Shang, Emmanuel Monnet, Greg Elson, Eric Hatterer
  • Patent number: 9688769
    Abstract: This invention relates generally to methods and compositions for diagnosing and treating disorders associated with elevated levels of Toll-like Receptor 4 (TLR4) ligands and other biomarkers. The invention also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder associated with elevated levels of TLR4 ligands and other biomarkers using agents that interfere with or otherwise antagonize TLR4 signaling, including neutralizing anti-TLR4 antibodies.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: June 27, 2017
    Assignee: NOVIMMUNE S.A.
    Inventors: Christina de Min, Limin Shang, Emmanuel Monnet, Greg Elson, Eric Hatterer
  • Publication number: 20170038381
    Abstract: This invention relates generally to methods and compositions for identifying patient populations for diagnosis and treatment of Toll-like Receptor 4 (TLR4)-dependent disorders. In particular, the invention relates to detecting levels of anti-citrullinated protein antibodies (ACPA) and citrullinated peptides to identify patients having a TLR4-dependent disease and to identify patients who are likely to respond to anti-TLR4 therapy. The invention also relates to methods of treating, delaying the progression of, or otherwise ameliorating a symptom of a disorder in patients with elevated levels of ACPA and citrullinated peptides using agents that interfere with or otherwise antagonize TLR-4 signaling, including neutralizing anti-TLR4 antibodies.
    Type: Application
    Filed: August 5, 2016
    Publication date: February 9, 2017
    Inventors: Emmanuel Monnet, Limin Shang
  • Patent number: 9101267
    Abstract: The present invention provides a method for real-time tracking of moving flexible surfaces and an image guided surgical robotic system using this tracking method. A vision system acquires an image of the moving flexible surface and identifies and tracks visual features at different times. The method involves computing both rigid and stretching transformations based on the changing positions of the visual features which are then used to track any area of interest on the moving flexible surface as it evolves over time. A robotic surgical system using this real-time tracking is disclosed.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: August 11, 2015
    Assignee: MACDONALD, DETTWILER AND ASSOCIATES INC.
    Inventors: Manickam Umasuthan, Raja Mukherji, Limin Shang
  • Publication number: 20150158946
    Abstract: This invention relates generally to anti-Toll-like Receptor 4 (TLR4 antagonists) including antibodies that specifically bind Toll-like Receptor 4 (TLR-4), to methods of using the anti-TLR4 antagonists as therapeutics and to methods of using the anti-TLR4 antagonists for inhibiting, delaying the progression of, or otherwise ameliorating a symptom of Graft-versus-Host disease (GvHD) and/or improving survival of GvHD subjects and/or transplanted biological materials in subjects.
    Type: Application
    Filed: December 8, 2014
    Publication date: June 11, 2015
    Inventors: Emmanuel Monnet, Limin Shang, Susana Salgado-Pires, Walter Ferlin, Greg Elson