Abstract: An online measuring system for the semi-volatile organic compounds in the gas phase is provided in the disclosure. The system comprises a filter head, a three-way electromagnetic valve, an enrichment-thermal desorption device, a two-position six-way valve, a mass flow controller, a gas pump, a gas chromatograph, a primary capture trap, a secondary focus trap, and a gas supply and pressure control system, the inlet of the filter head is connected to be provided with a sampling object, the outlet of the filter head is connected with the port B of the three-way electromagnetic valve through a passivated stainless steel tube, the port C of the three-way electromagnetic valve is connected with the inlet of the primary capture trap through a passivated stainless steel tube, and the port A of the three-way electromagnetic valve is connected to the gas supply and pressure control system through a passivated stainless steel tube.

Abstract: Provided are a phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and a use thereof; the structure of said phthalazinone compound is as represented by formula I; the compound of said formula I is targeted to a viral nucleocapsid; it can inhibit the replication of a virus by means of interference of the viral nucleocapsid, has a potent activity for inhibiting HBV DNA replication and a good liver targeting, can stably exist and enrich in the liver, and is a new and effective anti-HBV inhibitor.

Abstract: An o-aminoheteroaryl alkynyl-containing compound has a structure represented by formula (I), and the compound of formula (I) has advantages of a high FGFR and RET double target inhibitory activity and a relatively low KDR activity, and the compound of formula (I) exhibits a strong inhibitory activity in a human lung cancer cell line NCI-H1581 and a gastric cancer cell line SNU16 as well as an RET-dependent sensitive cell line BaF3-CCDC6-Ret and a mutant thereof. Pharmacokinetic data shows that the o-aminoheteroaryl alkynyl-containing compound has druggability, and exhibits significant relevant inhibition of the growth of related tumors in a long-term animal model of drug efficacy and results in favorable animal condition at effective doses.

Abstract: An online measuring system for the semi-volatile organic compounds in the gas phase is provided in the disclosure. The system comprises a filter head, a three-way electromagnetic valve, an enrichment-thermal desorption device, a two-position six-way valve, a mass flow controller, a gas pump, a gas chromatograph, a primary capture trap, a secondary focus trap, and a gas supply and pressure control system, the inlet of the filter head is connected to be provided with a sampling object, the outlet of the filter head is connected with the port B of the three-way electromagnetic valve through a passivated stainless steel tube, the port C of the three-way electromagnetic valve is connected with the inlet of the primary capture trap through a passivated stainless steel tube, and the port A of the three-way electromagnetic valve is connected to the gas supply and pressure control system through a passivated stainless steel tube.

Abstract: Provided are a phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and a use thereof; the structure of said phthalazinone compound is as represented by formula I; the compound of said formula I is targeted to a viral nucleocapsid; it can inhibit the replication of a virus by means of interference of the viral nucleocapsid, has a potent activity for inhibiting HBV DNA replication and a good liver targeting, can stably exist and enrich in the liver, and is a new and effective anti-HBV inhibitor.

Abstract: An o-aminoheteroaryl alkynyl-containing compound has a structure represented by formula (I), and the compound of formula (I) has advantages of a high FGFR and RET double target inhibitory activity and a relatively low KDR activity, and the compound of formula (I) exhibits a strong inhibitory activity in a human lung cancer cell line NCI-H1581 and a gastric cancer cell line SNU16 as well as an RET-dependent sensitive cell line BaF3-CCDC6-Ret and a mutant thereof. Pharmacokinetic data shows that the o-aminoheteroaryl alkynyl-containing compound has druggability, and exhibits significant relevant inhibition of the growth of related tumors in a long-term animal model of drug efficacy and results in favorable animal condition at effective doses.