Abstract: Disclosed are a molecular imaging method using Raman spectra and system based on machine learning cascade. The system includes a coordinate localization module, a hierarchical clustering analysis module, a Raman predictive imaging module, and a similarity analysis module. An untreated frozen tissue slice is attached to a stainless steel slide, and an adjacent slice is attached to a glass slide. The coordinate localization module can match a Raman white light image of a detection sample attached to the stainless steel slide with an immunohistochemistry (IHC) image of the adjacent slice, such that Raman spectra of a target region are accurately collected. The hierarchical clustering analysis module purifies different types of Raman spectra. A machine learning classifier is configured to build a Raman predictive imaging model. The similarity analysis module can evaluate similarity between a predicted Raman predictive image and the IHC image of the adjacent slice.

Abstract: The present invention relates to a compound of formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and a use thereof in the preparation of a drug for treating diseases related to WEE1 activity.

Abstract: High-protein food additives are prepared by reacting a protein material with L-cysteine, or a derivative thereof, with homogenization and heating. The homogenization and heating is preferably carried out on an aqueously slurry of the protein material and L-cysteine. The homogenized and reacted slurry is then dried to form a powder. The resultant food additive may be incorporated into a wide variety of food products to enhance the physical characteristics thereof.

Abstract: Starch spherulites are produced by debranching of amylopectin-containing starch into short linear ?-1,4-linked glucans (e.g., short-chain amylose, SCA). The debranched linear glucans are directly converted into spherulites by heating the debranched starch mixture followed by cooling and crystallization to form well-developed spherulites. The spherulites exhibit controlled enzyme digestibility.

Abstract: High-protein food additives are prepared by reacting a protein material with L-cysteine, or a derivative thereof, with homogenization and heating. The homogenization and heating is preferably carried out on an aqueously slurry of the protein material and L-cysteine. The homogenized and reacted slurry is then dried to form a powder. The resultant food additive may be incorporated into a wide variety of food products to enhance the physical characteristics thereof.

Abstract: Insulating cup includes an inner body and an outer body. The inner body has an inner sidewall defining a top opening and an inner bottom portion, and the inner sidewall includes a first circumferential rib and a second circumferential rib. The outer body has an outer sidewall surrounding at least a substantial portion of the inner sidewall and engaging the first circumferential rib and the second circumferential rib to define an insulating space therebetween, and the outer body has an outer bottom portion disposed below the inner bottom portion to define a surface-engaging edge.

Abstract: Starch spherulites are produced by debranching of amylopectin-containing starch into short linear ?-1,4-linked glucans (e.g., short-chain amylose, SCA). The debranched linear glucans are directly converted into spherulites by heating the debranched starch mixture followed by cooling and crystallization to form well-developed spherulites. The spherulites exhibit controlled enzyme digestibility.

Abstract: A food scoop of a generally upwardly tapering truncated configuration having a lower portion of rectangular cross section and an upper portion of circular cross section with a bottom in edge contact with the peripheral wall of the scoop completely thereabout and with opposed combined glue and sealing flaps integral with the bottom and bonded to opposed sides of the scoop wall and with the upper portion of the scoop terminating in a foldable closure means.

Abstract: An insulating lid includes a cover having an outer edge and a base. The base includes an upper surface, a lip projecting upwardly from the upper surface about an outer perimeter of the base to define an inner area, and a plurality of spacer members extending upwardly from the upper surface positioned within the inner area. The plurality of spacer members are configured to space the cover a distance from the upper surface of the base to define an insulating space between the cover and the upper surface of the base.

Abstract: Method of making a multilayer article including providing a first substrate and providing a second substrate. The method further includes disposing an expandable insulating material on an inner surface of at least one of the first substrate and the second substrate, wherein the expandable insulating material is in a first condition during disposing. The second substrate is adhered to the first substrate with the expandable insulating material therebetween to form a blank, wherein an insulating space is defined between the first substrate and the second substrate with the expandable insulating material therein and the insulating space includes a first volume. The method further includes forming the blank into the article and expanding the expandable insulating material to a second condition by application of energy, wherein the expandable insulating material in the second condition increases the insulating space to a second volume.

Abstract: Insulating cup includes an inner body and an outer body. The inner body has an inner sidewall defining a top opening and an inner bottom portion, and the inner sidewall includes a first circumferential rib and a second circumferential rib. The outer body has an outer sidewall surrounding at least a substantial portion of the inner sidewall and engaging the first circumferential rib and the second circumferential rib to define an insulating space therebetween, and the outer body has an outer bottom portion disposed below the inner bottom portion to define a surface-engaging edge.

Abstract: A food scoop of a generally upwardly tapering truncated configuration having a lower portion of rectangular cross section and an upper portion of circular cross section with a bottom in edge contact with the peripheral wall of the scoop completely thereabout and with opposed combined glue and sealing flaps integral with the bottom and bonded to opposed sides of the scoop wall and with the upper portion of the scoop terminating in a foldable closure means.

Abstract: An insulating lid includes a cover having an outer edge and a base. The base includes an upper surface, a lip projecting upwardly from the upper surface about an outer perimeter of the base to define an inner area, and a plurality of spacer members extending upwardly from the upper surface positioned within the inner area. The plurality of spacer members are configured to space the cover a distance from the upper surface of the base to define an insulating space between the cover and the upper surface of the base.

Abstract: A hot cup lid providing alternating modes of access to the contents of a cup, the lid including an enlarged drinking opening selectively closed by a tear flap, and a smaller sipping opening diametrically aligned with the drinking opening and adjacent the periphery of the lid, the tear flap including a sealing lug thereon engageable within and closing the sipping opening upon pivotal movement of the flap to open the drinking opening.

Abstract: A cup lid having a top panel with an upwardly projecting rim peripherally thereabout, a recessed channel in the top panel extends from a central area thereof to the rim, the channel having a bottom with a sipping opening defined therethrough adjacent the rim, a closure member selectively receivable in said channel for movement between open and closed positions relative to said opening, the closure member being integrally formed with said lid, or a companion cup, remote from said channel for selective severing therefrom and subsequent mounting within the channel.

Abstract: A clamshell container and sauce holder for receiving a sauce container is constructed from a one-piece carton blank cut and scored to facilitate erection into a clamshell container with top and bottom portions hingedly connected along a common fold line. A bottom portion of the container includes an upper flat section extending inwardly from a bottom side wall, an integral support and a base member including a tuck flap for positioning the upper flat section. In addition, an opening is defined in the upper flat section for holding a sauce container.

Abstract: A hot cup lid providing alternating modes of access to the contents of a cup, the lid including an enlarged drinking opening selectively closed by a tear flap, and a smaller sipping opening diametrically aligned with the drinking opening and adjacent the periphery of the lid, the tear flap including a sealing lug thereon engageable within and closing the sipping opening upon pivotal movement of the flap to open the drinking opening.

Abstract: A clamshell container and sauce holder for receiving a sauce container is constructed from a one-piece carton blank cut and scored to facilitate erection into a clamshell container with top and bottom portions hingedly connected along a common fold line. A bottom portion of the container includes an upper flat section extending inwardly from a bottom side wall, an integral support and a base member including a tuck flap for positioning the upper flat section. In addition, an opening is defined in the upper flat section for holding a sauce container.

Abstract: A cup lid having a top panel with an upwardly projecting rim peripherally thereabout, a recessed channel in the top panel extends from a central area thereof to the rim, the channel having a bottom with a sipping opening defined therethrough adjacent the rim, a closure member selectively receivable in said channel for movement between open and closed positions relative to said opening, the closure member being integrally formed with said lid, or a companion cup, remote from said channel for selective severing therefrom and subsequent mounting within the channel.

Abstract: A hot cup lid providing alternating modes of access to the contents of a cup, the lid including an enlarged drinking opening selectively closed by a tear flap, and a smaller sipping opening diametrically aligned with the drinking opening and adjacent the periphery of the lid, the tear flap including a sealing lug thereon engageable within and closing the sipping opening upon pivotal movement of the flap to open the drinking opening.