Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: The application discloses a coil structure, including a coil, both positive and negative tabs of the coil include a tab uncut area between the tab outer ring cut-out area and the tab center cut-out area, and along the axial direction of the coil, the tab uncut area protrudes from the tab outer ring cut-out area and the tab center cut-out area. After the above-mentioned cut-out area is cut by the cutting process, the problem that the edge of the tab is turned out after rubbing can be improved. The application also discloses a battery including the above-mentioned coil structure.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 dependent condition more specifically, by contacting the MRGPRX2 or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein D, W, Z, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: A cover plate of a cylindrical battery and the cylindrical battery are provided by the present application. The cover plate of the cylindrical battery includes a pole column. A bottom of the pole column is connected with a current collecting plate. The pole column is sleeved with a sealing ring. A first insulating element and a cover slip are sequentially sleeved on an outside of the sealing ring along a vertical direction. The first insulating element insulates the current collecting plate from the cover slip.

Abstract: Provided is a cylindrical lithium-ion battery including a negative cap and a cylindrical case. A jellyroll and a negative current collector are arranged inside the case. A sidewall of an end of the case is provided with an annular inwardly-concaved groove arranged circumferentially around a central axis of the case, and forms an annular protrusion at the inside of the case. The negative current collector is connected to a negative electrode of the j ellyroll. A portion, located below the annular inwardly-concaved groove, of the case is bent to form an annular engaging groove, an opening of the annular engaging groove faces the interior of the case, the periphery of the negative cap is arranged in the annular engaging groove, and a bottom surface of the negative cap and the annular engaging groove are connected in a sealed manner by laser welding.

Abstract: A conveying device (100) and an inspection system (1000) are provided. The conveying device includes: a first support frame (1); a first conveying mechanism (2) and a second conveying mechanism (3) which are installed on the first support frame; and a switching mechanism (4) configured to selectively lift the first conveying mechanism or the second conveying mechanism in a vertical direction, such that the first conveying mechanism or the second conveying mechanism carries goods (401) and conveys the goods in a first horizontal direction or a second horizontal direction different from the first horizontal direction. The conveying device may achieve a positioning and a smooth continuous conveying of goods, and achieve a smooth conveying and a calibrated positioning of the goods in different postures.

Abstract: Disclosed is a battery, including a shell assembly, a jellyroll, and a support bar. The shell assembly defines a receiving cavity. The jellyroll is received in the receiving cavity. The support bar is disposed at a middle portion of the jellyroll. Two ends of the support bar protrude to an outside of the jellyroll and abuts against two opposite inner walls of the shell assembly. Positions of the shell assembly abutted by the support bar are recessed to form positioning slots. The two ends of the support bar are inserted into the positioning slots. The shell assembly includes a shell and a cap set connected to the shell. The shell defines an opening, the cap set covers and seals the opening. At least one end of the support bar abuts against the cap set.

Abstract: A current collector, a battery cover plate, and a battery structure are provided. The current collector includes a first connection portion and a second connection portion. The first connection portion is connected to an electrode post holder, and the first connection portion and the second connection portion are connected through a bending-resistant portion. The battery cover plate includes the above current collector, an electrode post, and a top cover plate. The electrode post body penetrates the top cover plate to be connected to a terminal. The terminal and the current collector are disposed on opposite sides of the top cover plate, and the first connection portion of the current collector is connected to the electrode post.

Abstract: A battery and a battery module are provided. The battery includes a housing, a cell, and a current collector plate. A holding chamber is defined in the housing and a pressure relief valve is arranged on the housing; the cell is arranged in the holding chamber; the current collector plate includes a first side and a second side disposed opposite each other; the first side defines a first recess, and the first recess is spaced from the end surface of the cell; the second side defines a second recess, and the pressure relief valve is disposed directly opposite to the second recess; an edge of the current collector plate is spaced from a wall of the holding chamber to define a connection channel, and the first recess and the second recess are connected through the connection channel.

Abstract: Methods are provided for modulating MRGPR X2 generally, or for treating a MRGPR X2 or a MRGPR X2 ortholog dependent condition, more specifically, by contacting the MRGPR X2 or the MRGPR X2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Provided is a battery including a case and a cap plate. The case is a cylindrical groove structure, a top end face, facing towards the case, of the cap plate is provided with an annular protrusion, the annular protrusion has a central axis coinciding with the central axis of the cap plate, an edge of the top end face of the cap plate is provided with a first welding platform face, the first welding platform face is arranged circumferentially around the annular protrusion, and an outer sidewall of the annular protrusion and the first welding platform face constitute a stepped face. The annular protrusion enters the interior of the case via an annular bottom end face of the case, and the annular bottom end face of the case is in contact with the first welding platform face and connected to the first welding platform face by laser welding.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Disclosed is a battery comprising a housing, a battery cell and an end cover structure. The housing has an opening, through which the battery cell may be provided in the housing, and the end cover structure covers the opening. one end of the battery cell comprises a first electrode tab and a second electrode tab with different electrode polarities, the first and second electrode tabs are both towards the opening when the battery cell is provided in the housing, and the end cover structure comprises a first electrode connecting part and a second electrode connecting part, the first electrode connecting part is electrically connected to the first electrode tab and the second electrode connecting part is electrically connected to the second electrode tab when the end cover structure covers the opening, the first electrode connecting part and the second electrode connecting part are connected by insulating sealing part.

Abstract: Methods are provided for modulating MRGPR X4 generally, or for treating a MRGPR X4 dependent condition more specifically, by contacting the MRGPR X4 or administering to a subject in need thereof, respectively, an effective amount of a compound having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein n, x, A, Q1, Q2, Z, R, R1, R2, R3, R4 and R5 are as defined herein. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

Abstract: The present application provides a battery housing assembly and a battery. The housing assembly comprises a housing body, an electrode column and an insulating part, wherein the housing body is provided with a mounting hole, the electrode column penetrates the mounting hole, the column body comprises a first end and a second end, the second end is provided inside the housing body, the first end is provided with a restricting part, the second end is provided with a riveting part, the restricting part and the riveting part jointly clamp the insulating part and the housing body, the end surface of the second end is provided with a groove, and the groove is adjacent to the riveting part.

Abstract: Methods are provided for modulating MRGPR X4 generally, or for treating a MRGPR X4 dependent condition more specifically, by contacting the MRGPR X4 or administering to a subject in need thereof, respectively, an effective amount of a compound having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein m, n, p, t, A, B, Z, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 dependent condition more specifically, by contacting the MRGPRX2 or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein A, B, C, D, E, G, W, Y, Z, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: The present application discloses a cap assembly of a battery, a cylindrical battery, and a battery pack. The battery pack includes multiple cylindrical batteries. The cylindrical battery includes a cylindrical shell defining an opening and a cap assembly covering the opening. The cap assembly includes a cap, a pole, a terminal, and a sealing pin. The cap defines a liquid injection hole. The pole is disposed on a first side of the cap. The terminal is disposed on a second side of the cap and electrically connected to the pole. The second side of the cap is opposite to the first side of the cap. The sealing pin is configured to seal the liquid injection hole, and has a thinning region configured for an explosion-proof function.