Abstract: An inspection system and method, the inspection system includes: a carrying device, at least one ray source and a detector assembly. The ray source and the detector assembly are lifted or lowered along a central axis of the carrying device relative to the carrying device. When viewed along the central axis, the ray source is translatable between scanning positions relative to the carrying device. When the ray source is at one of the scanning positions the ray source and the detector assembly are lifted or lowered relative to the carrying device along the central axis, and the ray source emits X-rays; and when the ray source and the detector assembly are lifted or lowered a predetermined distance the ray source translates to another scanning position. The inspection system further reconstructs a three-dimensional scanning image of the object to be inspected based on detection data of the detector assembly.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Provided are an assembled structure of a pole and a pole current collector disk. The assembled structure includes a positive pole, a positive current collector disk, a first insulating member and a second insulating member, where the second insulating member is disposed between the positive current collector disk and the first insulating member. The positive pole includes a conductive end and a connection end, the conductive end and the connection end are connected through the connection rod. The connection rod sequentially penetrates through the first insulating member and the second insulating member, the first insulating member is closer to the conductive end than the second insulating member, and an accommodating space is formed between the first insulating member and the second insulating member. The positive current collector disk includes a welding disk and a conductive protrusion.

Abstract: An explosion-proof valve, a cover plate of a battery and a battery are provided. The explosion-proof valve includes an annular groove, and the annular groove divides the explosion-proof valve into a rupture portion and a fixed portion. A pressure-bearing groove that is arc-shaped is recessedly provided on one side of the rupture portion. A bottom of the pressure-bearing groove is located within the annular groove.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPR X2 generally, or for treating a MRGPR X2 dependent condition more specifically, by contacting the MRGPR X2 or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPR X2 generally, or for treating a MRGPR X2 or a MRGPR X2 ortholog dependent condition, more specifically, by contacting the MRGPR X2 or the MRGPR X2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: The present application provides a battery cover plate and a battery. The battery cover plate includes a cover plate body, a first seal, a second seal, and a sealing ring. The cover plate body is provided with a liquid injection hole, the first seal is attached to a hole wall of the liquid injection hole and is provided with a threaded hole extending along an axis direction of the liquid injection hole. The second seal includes a head and a connecting part, a diameter of the head is greater than a diameter of the connecting part, a first step surface is defined between the head and the connecting part, the connecting part is provided with an external thread threadedly connected to the threaded hole. The sealing ring is sleeved on the connecting part and located between the first step surface and an upper surface of the cover plate body.

Abstract: A battery is provided. The battery includes a housing, a jellyroll, a first current collector plate, a second current collector plate, an output terminal, and a cover board. A top wall of the housing is provided with a through hole, and a bottom of the housing is provided with an open end. A first tab and a second tab are provided on ends of the jellyroll respectively in an axial direction of the jellyroll. The first tab is connected to the first current collector plate, and the second tab is connected to the housing via the second current collector plate. The output terminal is sealed in the through hole and connected to the first current collector plate. The cover board is sealed and insulated at the open end of the bottom of the housing.

Abstract: The present disclosure relates to the field of battery technology. A battery cell with directional pressure relief and a battery module are provided. The battery cell with directional pressure relief includes a housing and a cover plate, and the cover plate is buckled on the housing. The cover plate is provided with an explosion-proof valve, the explosion-proof valve includes an arc notch and a connecting portion, the arc notch and the connecting portion are connected end-to-end to enclose and define a circular structure, and the circular structure separates the cover plate into a circular part and an annular part. When a thermal runaway occurs, the explosion-proof valve is flushed open, the arc notch is fractured, and the circular part is turned around the connecting portion.

Abstract: An internal connection structure of a battery terminal and a battery, the internal connection structure of the battery terminal includes a a roll core, a first current collector, and a snapping portion. The roll core is provided with a first electrode tab and a second electrode tab. The first current collector is connected to the first electrode tab, and the first current collector is provided with a hole. The snapping portion is disposed on an inner side of the battery terminal, the snapping portion is snapped through the hole, the battery terminal passes through the hole and is snapped and assembled with the first current collector through the snapping portion, and the battery terminal is configured to enable a positive end of the roll core extend outwards.

Abstract: A current collecting plate and a battery are provided. The battery includes a roll core, a pole and a current collecting plate, the roll core is welded to the current collecting plate, and the pole is electrically connected with the roll core through the current collecting plate. The current collecting plate includes a main body part and a welding part, the welding part is bent relative to the main body part, and the current collecting plate is welded with the roll core through the welding part.

Abstract: Methods are provided for modulating MRGPR X4 generally, or for treating a MRGPR X4 dependent condition more specifically, by contacting the MRGPR X4 or administering to a subject in need thereof, respectively, an effective amount of a compound having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein n, x, A, Q1, Q2, Z, R, R1, R2, R3, R4 and R5 are as defined herein. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

Abstract: A cylindrical battery and a battery pack are provided in embodiments of the application, which relates to the field of battery technology. The cylindrical battery includes a housing, a first end cover, a second end cover, a battery cell, and a pole post. The battery cell is accommodated in the housing, and the first end cover and the second end cover seal at ends of the housing, respectively. The pole post is connected with the battery cell and extended through the first end cover. The pole post is cylindrical, a diameter of the pole post is ?1, and a diameter of the first end cover is ?2, wherein ?1/?2?34%, and ?1?12 mm.

Abstract: A lid plate and a battery are provided by the present application. The lid plate includes a top lid, a lower plastic and a current collecting disk. The top lid is stacked with the lower plastic. An accommodating space is defined on a side of the lower plastic away from the top lid. Supporting protrusions are provided in the accommodating space. The supporting protrusions are configured to defined a limiting space. The current collecting disk includes the current collecting disk main body and the fuse structure. The fuse structure includes a first part and a second part. The first part is electrically connected to the top lid through the lower plastic, the second part is connected to the current collecting disk main body. The current collecting disk main body is located outside the limiting space and abuts against the supporting protrusions.

Abstract: Methods are provided for modulating MRGPR X4 generally, or for treating a MRGPR X4-dependent condition more specifically, by contacting MRGPR X4 or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein E, Q, W, Z, R1, R2, R3, and R4 are as defined herein. Pharmaceutical compositions containing such compounds, as well as compounds themselves, are also provided.

Abstract: Provided is a cylindrical battery which includes a case, a positive pole and an insulation sealing member. The case is a cylindrical groove structure. The positive pole is riveted to the case, and the insulation sealing member is arranged between the positive pole and the case. The insulation sealing member comprises an upper insulation sealing member and a lower insulation sealing member, the upper insulation sealing member is arranged outside the case and is engaged with and connected to the case, and the lower insulation sealing member is arranged inside the case. At least one of the upper insulation sealing member and the lower insulation sealing member is provided with an annular protrusion block, the annular protrusion block fits closely against an outer sidewall of a portion, passing through the case, of the positive pole.

Abstract: Methods are provided for modulating MRGPRD generally, or for treating a MRGPRD dependent condition more specifically, by contacting the MRGPRD or administering to a subject in need thereof, respectively, an effective amount of a compound having the structure of Formula (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein A, B, C, D, L, R1, R2, R3, R4, m, n, and p are as defined herein. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 dependent condition more specifically, by contacting the MRGPRX2 or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein D, W, Z, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.