Abstract: Methods are provided for modulating MRGPRD generally, or for treating a MRGPRD dependent condition more specifically, by contacting the MRGPRD or administering to a subject in need thereof, respectively, an effective amount of a compound having the structure of Formula (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein A, B, C, D, L, R1, R2, R3, R4, m, n, and p are as defined herein. Pharmaceutical compositions containing such compounds, as well as to compounds themselves, are also provided.

Abstract: Provided is a cylindrical battery which includes a case, a positive pole and an insulation sealing member. The case is a cylindrical groove structure. The positive pole is riveted to the case, and the insulation sealing member is arranged between the positive pole and the case. The insulation sealing member comprises an upper insulation sealing member and a lower insulation sealing member, the upper insulation sealing member is arranged outside the case and is engaged with and connected to the case, and the lower insulation sealing member is arranged inside the case. At least one of the upper insulation sealing member and the lower insulation sealing member is provided with an annular protrusion block, the annular protrusion block fits closely against an outer sidewall of a portion, passing through the case, of the positive pole.

Abstract: Provided are an assembled structure of a pole and a pole current collector disk. The assembled structure includes a positive pole, a positive current collector disk, a first insulating member and a second insulating member, where the second insulating member is disposed between the positive current collector disk and the first insulating member. The positive pole includes a conductive end and a connection end, the conductive end and the connection end are connected through the connection rod. The connection rod sequentially penetrates through the first insulating member and the second insulating member, the first insulating member is closer to the conductive end than the second insulating member, and an accommodating space is formed between the first insulating member and the second insulating member. The positive current collector disk includes a welding disk and a conductive protrusion.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 dependent condition more specifically, by contacting the MRGPRX2 or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein D, W, Z, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: The present application relates to the field of battery technology, and discloses a cylindrical battery structure including a cover plate and a housing. The cover plate includes a cover plate main portion and a cover plate connecting portion fixedly connected to each other. One of an edge of the cover plate connecting portion and an edge of the housing is bent to form a bent portion, and another of the edge of the housing and the edge of the cover plate connecting portion is bent to form a hook portion. The hook portion is configured to hang on the bent portion to connect the cover plate and the housing. The cylindrical battery structure disclosed in the application has simpler connection mode, lower connection cost, and faster connection. In addition, the connection mode has lower requirements on assembly accuracy of workpieces in the housing.

Abstract: Provided is a current collector disk, the current collector disk includes a welding disk and multiple support feet connected to the welding disk, the welding disk is provided with multiple through holes, the multiple through holes vertically penetrate through an upper end surface and a lower end surface of the welding disk, and a direction of end surfaces, facing away the welding disk, of the multiple support feet is the same as a direction of the lower end surface of the welding disk. Further provided is a battery, and the battery is provided with the current collector disk described above.

Abstract: A crystalline form of 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid and a method for its preparation are described. The crystalline form is further suitable as intermediate compound to prepare Form 1, Form 4 and Form M with improved stability and purity.

Abstract: Example communication methods and systems based on a user-mode protocol stack are provided. One example method is applied to a service side, where the service side includes an application layer, the user-mode protocol stack, and a hardware layer. A target application of the application layer corresponds to at least one W thread. The example method includes obtaining, by using a routing module, a first correspondence and a second correspondence, where the first correspondence includes a correspondence between a listen file descriptor (FD) of a first W thread and a plurality of shadow FDs, and the second correspondence includes a correspondence between a target N thread and a connection FD. Communication with a client is performed using the routing module based on the first correspondence and the second correspondence.

Abstract: Methods are provided for modulating MRGPRX2 or a MRGPRX2 ortholog generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 or a MRGPRX2 ortholog dependent condition, more specifically, by contacting the MRGPRX2 or the MRGPRX2 ortholog by administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein W, Z, R1, R2, R3, R4, R5, R6 and Rx are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: The application discloses a coil structure, including a coil, both positive and negative tabs of the coil include a tab uncut area between the tab outer ring cut-out area and the tab center cut-out area, and along the axial direction of the coil, the tab uncut area protrudes from the tab outer ring cut-out area and the tab center cut-out area. After the above-mentioned cut-out area is cut by the cutting process, the problem that the edge of the tab is turned out after rubbing can be improved. The application also discloses a battery including the above-mentioned coil structure.

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 dependent condition more specifically, by contacting the MRGPRX2 or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I): or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein D, W, Z, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

Abstract: Provided is a cylindrical lithium-ion battery including a negative cap and a cylindrical case. A jellyroll and a negative current collector are arranged inside the case. A sidewall of an end of the case is provided with an annular inwardly-concaved groove arranged circumferentially around a central axis of the case, and forms an annular protrusion at the inside of the case. The negative current collector is connected to a negative electrode of the j ellyroll. A portion, located below the annular inwardly-concaved groove, of the case is bent to form an annular engaging groove, an opening of the annular engaging groove faces the interior of the case, the periphery of the negative cap is arranged in the annular engaging groove, and a bottom surface of the negative cap and the annular engaging groove are connected in a sealed manner by laser welding.

Abstract: A cover plate of a cylindrical battery and the cylindrical battery are provided by the present application. The cover plate of the cylindrical battery includes a pole column. A bottom of the pole column is connected with a current collecting plate. The pole column is sleeved with a sealing ring. A first insulating element and a cover slip are sequentially sleeved on an outside of the sealing ring along a vertical direction. The first insulating element insulates the current collecting plate from the cover slip.

Abstract: Disclosed is a battery, including a shell assembly, a jellyroll, and a support bar. The shell assembly defines a receiving cavity. The jellyroll is received in the receiving cavity. The support bar is disposed at a middle portion of the jellyroll. Two ends of the support bar protrude to an outside of the jellyroll and abuts against two opposite inner walls of the shell assembly. Positions of the shell assembly abutted by the support bar are recessed to form positioning slots. The two ends of the support bar are inserted into the positioning slots. The shell assembly includes a shell and a cap set connected to the shell. The shell defines an opening, the cap set covers and seals the opening. At least one end of the support bar abuts against the cap set.

Abstract: A current collector, a battery cover plate, and a battery structure are provided. The current collector includes a first connection portion and a second connection portion. The first connection portion is connected to an electrode post holder, and the first connection portion and the second connection portion are connected through a bending-resistant portion. The battery cover plate includes the above current collector, an electrode post, and a top cover plate. The electrode post body penetrates the top cover plate to be connected to a terminal. The terminal and the current collector are disposed on opposite sides of the top cover plate, and the first connection portion of the current collector is connected to the electrode post.

Abstract: A battery and a battery module are provided. The battery includes a housing, a cell, and a current collector plate. A holding chamber is defined in the housing and a pressure relief valve is arranged on the housing; the cell is arranged in the holding chamber; the current collector plate includes a first side and a second side disposed opposite each other; the first side defines a first recess, and the first recess is spaced from the end surface of the cell; the second side defines a second recess, and the pressure relief valve is disposed directly opposite to the second recess; an edge of the current collector plate is spaced from a wall of the holding chamber to define a connection channel, and the first recess and the second recess are connected through the connection channel.