Patents by Inventor Liming Shao

Liming Shao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240358675
    Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Application
    Filed: January 18, 2024
    Publication date: October 31, 2024
    Applicants: Sumitomo Pharma America, Inc., PGI Drug Discovery LLC
    Inventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
  • Patent number: 11999642
    Abstract: A method for removing calcium ions from high concentration organic wastewater is provided. The method comprises the steps of: (1) introducing high concentration organic wastewater containing Ca2+, inorganic carbon and a seed crystal into a reactor with a molar ratio of Ca2+ to inorganic carbon of 1:(3.2-6.2); (2) adjusting the hydrogen ion activity ?(H+) and ionic strength of the solution in the reactor; (3) sequentially stirring and precipitating in the reactor to convert Ca2+ in the high concentration organic wastewater into calcium carbonate which is then precipitated for calcium removal.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: June 4, 2024
    Assignee: TONGJI UNIVERSITY
    Inventors: Pinjing He, Junjie Qiu, Liming Shao, Fan Lyu, Hua Zhang
  • Patent number: 11952536
    Abstract: Disclosed is a carbon-dioxide-responsive self-thickening intelligent fluid based on supramolecular self-assembly, which comprises a Gemini surfactant, a single-chain amide molecule having a tertiary amine head group and water, wherein the Gemini surfactant and the single-chain amide molecule are self-assembled to form a vesicle structure dispersed in water, with a hydrophilic head group being located outside and a hydrophobic tail group located inside. The method for preparing the carbon-dioxide-responsive self-thickening intelligent fluid of the present invention is simple, the injection viscosity is low, and the fluid is converted into a gel when encountering carbon dioxide, so that the viscosity is greatly increased.
    Type: Grant
    Filed: May 9, 2022
    Date of Patent: April 9, 2024
    Assignee: PetroChina Company Limited
    Inventors: Chunming Xiong, Falin Wei, Haiyang Yang, Yongjun Xie, Liming Shao, Kang Peng, Zhihui Zeng
  • Publication number: 20220387382
    Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Application
    Filed: January 13, 2022
    Publication date: December 8, 2022
    Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
  • Publication number: 20220259485
    Abstract: Disclosed is a carbon-dioxide-responsive self-thickening intelligent fluid based on supramolecular self-assembly, which comprises a Gemini surfactant, a single-chain amide molecule having a tertiary amine head group and water, wherein the Gemini surfactant and the single-chain amide molecule are self-assembled to form a vesicle structure dispersed in water, with a hydrophilic head group being located outside and a hydrophobic tail group located inside. The method for preparing the carbon-dioxide-responsive self-thickening intelligent fluid of the present invention is simple, the injection viscosity is low, and the fluid is converted into a gel when encountering carbon dioxide, so that the viscosity is greatly increased.
    Type: Application
    Filed: May 9, 2022
    Publication date: August 18, 2022
    Inventors: Chunming Xiong, Falin Wei, Haiyang Yang, Yongjun Xie, Liming Shao, Kang Peng, Zhihui Zeng
  • Patent number: 11332462
    Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: May 17, 2022
    Assignees: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: John Emmerson Campbell, Una Campbell, Taleen G. Hanania, Liming Shao
  • Publication number: 20220117913
    Abstract: Provided are a dezocine derivative represented by Formula I, or a tautomer, optical isomer, nitrogen oxide, solvate, pharmaceutically acceptable salt or prodrug thereof, as well as a pharmaceutical composition containing the same, preparations thereof, and medical use thereof, and the structure of Formula I is as below:
    Type: Application
    Filed: January 31, 2020
    Publication date: April 21, 2022
    Inventors: Liming SHAO, Tao HU, Haoyu XU, Lingwu CHEN, Yiquan ZOU, Wei CAI, Xicheng YANG, Haodong LI, Dengqi XUE
  • Publication number: 20220009808
    Abstract: A method for removing calcium ions from high concentration organic wastewater is provided. The method comprises the steps of: (1) introducing high concentration organic wastewater containing Ca2+, inorganic carbon and a seed crystal into a reactor with a molar ratio of Ca2+ to inorganic carbon of 1:(3.2-6.2); (2) adjusting the hydrogen ion activity ?(H+) and ionic strength of the solution in the reactor; (3) sequentially stirring and precipitating in the reactor to convert Ca2+ in the high concentration organic wastewater into calcium carbonate which is then precipitated for calcium removal.
    Type: Application
    Filed: November 25, 2019
    Publication date: January 13, 2022
    Applicant: TONGJI UNIVERSITY
    Inventors: Pinjing He, Junjie Qiu, Liming Shao, Fan Lyu, Hua Zhang
  • Publication number: 20210267938
    Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Application
    Filed: November 19, 2020
    Publication date: September 2, 2021
    Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
  • Patent number: 10894033
    Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: January 19, 2021
    Assignees: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Liming Shao, John Emmerson Campbell, Michael Charles Hewitt, Una Campbell, Taleen G. Hanania
  • Publication number: 20200323819
    Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Application
    Filed: February 14, 2020
    Publication date: October 15, 2020
    Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
  • Publication number: 20200277286
    Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Application
    Filed: December 20, 2019
    Publication date: September 3, 2020
    Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: John Emmerson CAMPBELL, Una CAMPBELL, Taleen G. HANANIA, Liming SHAO
  • Patent number: 10730808
    Abstract: The present invention relates to a self-deodorizing composting system, comprising an outer membrane, an inner membrane, an air-ribbed cage and a deodorizing base, wherein two deodorizing bases are provided; the outer membrane and the inner membrane are held by the air-ribbed cage, with both ends of the outer membrane and the inner membrane respectively fixed to the two deodorizing bases, whereby a closed space is formed between the outer membrane and the inner membrane; the inner side of the inner membrane is used for placing the composting piles, with the malodor and water vapor generated from the composting piles entering into the closed space formed between the outer membrane and the inner membrane through the inner membrane, so that the water vapor is condensed into the water in the closed space, and the malodor molecules are absorbed and dissolved into the condensed water, thus forming the waste water which falls along the inner side of the outer membrane and the outer side of the inner membrane to the b
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: August 4, 2020
    Assignee: TONGJI UNIVERSITY
    Inventors: Fan Lyu, Pinjing He, Liming Shao, Hua Zhang
  • Patent number: 10562878
    Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: February 18, 2020
    Assignee: SUNOVION PHARAMCEUTICALS INC.
    Inventors: Liming Shao, Fengjiang Wang, Scott Christopher Malcolm, Michael Charles Hewitt, Larry R. Bush, Jianguo Ma, Mark A. Varney, Una Campbell, Sharon Rae Engel, Larry Wendell Hardy, Patrick Koch, John E. Campell
  • Patent number: 10556890
    Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: February 11, 2020
    Assignees: Sunovion Pharmaceuticals Inc., PGI DRUG DISCOVERY LLC
    Inventors: John Emmerson Campbell, Una Campbell, Taleen G. Hanania, Liming Shao
  • Patent number: 10428021
    Abstract: Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: October 1, 2019
    Assignee: Sunovion Pharmaceuticals Inc.
    Inventors: Liming Shao, Fengjiang Wang, Scott C. Malcolm, Michael C. Hewitt
  • Patent number: 10357742
    Abstract: The present invention relates to a method for inhibiting the formation of dioxin-like compounds in solid waste incineration flue gases, belonging to the field of cleaning of solid waste incineration flue gases. In accordance with the present invention, when incineration flue gases cool down to 500˜450° C., the flue gases are introduced into an inhibition reactor where copper chlorides in flue gas particulates mix and react with inhibitors to convert into copper metaphosphate so as to inactivate the copper chlorides which can catalyze the formation of dioxin-like compounds and control dioxin-like compound pollutants in incineration flue gases at the source. Compared with the prior art, the invention can effectively control the main formation ways of dioxin-like compounds in solid waste incineration flue gases by optimizing inhibitors and reaction conditions.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: July 23, 2019
    Assignee: TONGJI UNIVERSITY
    Inventors: Pinjing He, Hua Zhang, Sijia Wang, Liming Shao, Fan Lyu
  • Publication number: 20190125722
    Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Application
    Filed: August 30, 2018
    Publication date: May 2, 2019
    Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
    Inventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
  • Patent number: 10196569
    Abstract: The present invention discloses a method and a system of treating biomass wastes by biochemistry-thermochemistry multi-point interconnection. The present invention applies solid, gas and liquid products of the thermochemical treatment subsystem to the biochemical treatment subsystem and applies heat produced by the biochemical treatment subsystem to the thermochemical treatment subsystem, forming multi-point and two-way interconnection between the biochemical treatment subsystem and the thermochemical treatment subsystem, thereby increasing the yield and stability of energy gas of the biochemical treatment subsystem and reducing pollution and energy consumption of the thermochemical treatment subsystem respectively. The present invention is suitable for treating biomass wastes with high and low water contents at the same time, producing soil amendment, liquid fuel and biogas, having properties of low secondary pollution and significant reduction of greenhouse gas emission and so on.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: February 5, 2019
    Assignee: TONGJI UNIVERSITY
    Inventors: Fan Lyu, Pinjing He, Liming Shao, Hua Zhang
  • Patent number: 10189825
    Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: January 29, 2019
    Assignees: SUNOVION PHARMACEUTICALS INC., PGI DRUG DISCOVERY LLC
    Inventors: John Emmerson Campbell, Una Campbell, Taleen G. Hanania, Liming Shao