Patents by Inventor Liming Shao
Liming Shao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240358675Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: ApplicationFiled: January 18, 2024Publication date: October 31, 2024Applicants: Sumitomo Pharma America, Inc., PGI Drug Discovery LLCInventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
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Patent number: 11999642Abstract: A method for removing calcium ions from high concentration organic wastewater is provided. The method comprises the steps of: (1) introducing high concentration organic wastewater containing Ca2+, inorganic carbon and a seed crystal into a reactor with a molar ratio of Ca2+ to inorganic carbon of 1:(3.2-6.2); (2) adjusting the hydrogen ion activity ?(H+) and ionic strength of the solution in the reactor; (3) sequentially stirring and precipitating in the reactor to convert Ca2+ in the high concentration organic wastewater into calcium carbonate which is then precipitated for calcium removal.Type: GrantFiled: November 25, 2019Date of Patent: June 4, 2024Assignee: TONGJI UNIVERSITYInventors: Pinjing He, Junjie Qiu, Liming Shao, Fan Lyu, Hua Zhang
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Patent number: 11952536Abstract: Disclosed is a carbon-dioxide-responsive self-thickening intelligent fluid based on supramolecular self-assembly, which comprises a Gemini surfactant, a single-chain amide molecule having a tertiary amine head group and water, wherein the Gemini surfactant and the single-chain amide molecule are self-assembled to form a vesicle structure dispersed in water, with a hydrophilic head group being located outside and a hydrophobic tail group located inside. The method for preparing the carbon-dioxide-responsive self-thickening intelligent fluid of the present invention is simple, the injection viscosity is low, and the fluid is converted into a gel when encountering carbon dioxide, so that the viscosity is greatly increased.Type: GrantFiled: May 9, 2022Date of Patent: April 9, 2024Assignee: PetroChina Company LimitedInventors: Chunming Xiong, Falin Wei, Haiyang Yang, Yongjun Xie, Liming Shao, Kang Peng, Zhihui Zeng
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Publication number: 20220387382Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: ApplicationFiled: January 13, 2022Publication date: December 8, 2022Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLCInventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
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Publication number: 20220259485Abstract: Disclosed is a carbon-dioxide-responsive self-thickening intelligent fluid based on supramolecular self-assembly, which comprises a Gemini surfactant, a single-chain amide molecule having a tertiary amine head group and water, wherein the Gemini surfactant and the single-chain amide molecule are self-assembled to form a vesicle structure dispersed in water, with a hydrophilic head group being located outside and a hydrophobic tail group located inside. The method for preparing the carbon-dioxide-responsive self-thickening intelligent fluid of the present invention is simple, the injection viscosity is low, and the fluid is converted into a gel when encountering carbon dioxide, so that the viscosity is greatly increased.Type: ApplicationFiled: May 9, 2022Publication date: August 18, 2022Inventors: Chunming Xiong, Falin Wei, Haiyang Yang, Yongjun Xie, Liming Shao, Kang Peng, Zhihui Zeng
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Patent number: 11332462Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: GrantFiled: December 20, 2019Date of Patent: May 17, 2022Assignees: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLCInventors: John Emmerson Campbell, Una Campbell, Taleen G. Hanania, Liming Shao
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Publication number: 20220117913Abstract: Provided are a dezocine derivative represented by Formula I, or a tautomer, optical isomer, nitrogen oxide, solvate, pharmaceutically acceptable salt or prodrug thereof, as well as a pharmaceutical composition containing the same, preparations thereof, and medical use thereof, and the structure of Formula I is as below:Type: ApplicationFiled: January 31, 2020Publication date: April 21, 2022Inventors: Liming SHAO, Tao HU, Haoyu XU, Lingwu CHEN, Yiquan ZOU, Wei CAI, Xicheng YANG, Haodong LI, Dengqi XUE
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Publication number: 20220009808Abstract: A method for removing calcium ions from high concentration organic wastewater is provided. The method comprises the steps of: (1) introducing high concentration organic wastewater containing Ca2+, inorganic carbon and a seed crystal into a reactor with a molar ratio of Ca2+ to inorganic carbon of 1:(3.2-6.2); (2) adjusting the hydrogen ion activity ?(H+) and ionic strength of the solution in the reactor; (3) sequentially stirring and precipitating in the reactor to convert Ca2+ in the high concentration organic wastewater into calcium carbonate which is then precipitated for calcium removal.Type: ApplicationFiled: November 25, 2019Publication date: January 13, 2022Applicant: TONGJI UNIVERSITYInventors: Pinjing He, Junjie Qiu, Liming Shao, Fan Lyu, Hua Zhang
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Publication number: 20210267938Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: ApplicationFiled: November 19, 2020Publication date: September 2, 2021Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLCInventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
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Patent number: 10894033Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: GrantFiled: February 14, 2020Date of Patent: January 19, 2021Assignees: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLCInventors: Liming Shao, John Emmerson Campbell, Michael Charles Hewitt, Una Campbell, Taleen G. Hanania
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Publication number: 20200323819Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: ApplicationFiled: February 14, 2020Publication date: October 15, 2020Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLCInventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
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Publication number: 20200277286Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: ApplicationFiled: December 20, 2019Publication date: September 3, 2020Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLCInventors: John Emmerson CAMPBELL, Una CAMPBELL, Taleen G. HANANIA, Liming SHAO
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Patent number: 10730808Abstract: The present invention relates to a self-deodorizing composting system, comprising an outer membrane, an inner membrane, an air-ribbed cage and a deodorizing base, wherein two deodorizing bases are provided; the outer membrane and the inner membrane are held by the air-ribbed cage, with both ends of the outer membrane and the inner membrane respectively fixed to the two deodorizing bases, whereby a closed space is formed between the outer membrane and the inner membrane; the inner side of the inner membrane is used for placing the composting piles, with the malodor and water vapor generated from the composting piles entering into the closed space formed between the outer membrane and the inner membrane through the inner membrane, so that the water vapor is condensed into the water in the closed space, and the malodor molecules are absorbed and dissolved into the condensed water, thus forming the waste water which falls along the inner side of the outer membrane and the outer side of the inner membrane to the bType: GrantFiled: June 30, 2017Date of Patent: August 4, 2020Assignee: TONGJI UNIVERSITYInventors: Fan Lyu, Pinjing He, Liming Shao, Hua Zhang
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Patent number: 10562878Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.Type: GrantFiled: December 8, 2017Date of Patent: February 18, 2020Assignee: SUNOVION PHARAMCEUTICALS INC.Inventors: Liming Shao, Fengjiang Wang, Scott Christopher Malcolm, Michael Charles Hewitt, Larry R. Bush, Jianguo Ma, Mark A. Varney, Una Campbell, Sharon Rae Engel, Larry Wendell Hardy, Patrick Koch, John E. Campell
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Patent number: 10556890Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: GrantFiled: December 22, 2017Date of Patent: February 11, 2020Assignees: Sunovion Pharmaceuticals Inc., PGI DRUG DISCOVERY LLCInventors: John Emmerson Campbell, Una Campbell, Taleen G. Hanania, Liming Shao
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Patent number: 10428021Abstract: Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.Type: GrantFiled: November 20, 2017Date of Patent: October 1, 2019Assignee: Sunovion Pharmaceuticals Inc.Inventors: Liming Shao, Fengjiang Wang, Scott C. Malcolm, Michael C. Hewitt
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Patent number: 10357742Abstract: The present invention relates to a method for inhibiting the formation of dioxin-like compounds in solid waste incineration flue gases, belonging to the field of cleaning of solid waste incineration flue gases. In accordance with the present invention, when incineration flue gases cool down to 500˜450° C., the flue gases are introduced into an inhibition reactor where copper chlorides in flue gas particulates mix and react with inhibitors to convert into copper metaphosphate so as to inactivate the copper chlorides which can catalyze the formation of dioxin-like compounds and control dioxin-like compound pollutants in incineration flue gases at the source. Compared with the prior art, the invention can effectively control the main formation ways of dioxin-like compounds in solid waste incineration flue gases by optimizing inhibitors and reaction conditions.Type: GrantFiled: January 18, 2017Date of Patent: July 23, 2019Assignee: TONGJI UNIVERSITYInventors: Pinjing He, Hua Zhang, Sijia Wang, Liming Shao, Fan Lyu
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Publication number: 20190125722Abstract: Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: ApplicationFiled: August 30, 2018Publication date: May 2, 2019Applicants: Sunovion Pharmaceuticals Inc., PGI Drug Discovery LLCInventors: Liming SHAO, John Emmerson CAMPBELL, Michael Charles HEWITT, Una CAMPBELL, Taleen G. HANANIA
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Patent number: 10196569Abstract: The present invention discloses a method and a system of treating biomass wastes by biochemistry-thermochemistry multi-point interconnection. The present invention applies solid, gas and liquid products of the thermochemical treatment subsystem to the biochemical treatment subsystem and applies heat produced by the biochemical treatment subsystem to the thermochemical treatment subsystem, forming multi-point and two-way interconnection between the biochemical treatment subsystem and the thermochemical treatment subsystem, thereby increasing the yield and stability of energy gas of the biochemical treatment subsystem and reducing pollution and energy consumption of the thermochemical treatment subsystem respectively. The present invention is suitable for treating biomass wastes with high and low water contents at the same time, producing soil amendment, liquid fuel and biogas, having properties of low secondary pollution and significant reduction of greenhouse gas emission and so on.Type: GrantFiled: May 31, 2016Date of Patent: February 5, 2019Assignee: TONGJI UNIVERSITYInventors: Fan Lyu, Pinjing He, Liming Shao, Hua Zhang
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Patent number: 10189825Abstract: Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.Type: GrantFiled: February 8, 2013Date of Patent: January 29, 2019Assignees: SUNOVION PHARMACEUTICALS INC., PGI DRUG DISCOVERY LLCInventors: John Emmerson Campbell, Una Campbell, Taleen G. Hanania, Liming Shao