Abstract: Disclosed are a strain for producing nattokinase and a production method therefor. In particular, the present invention involves a novel strain capable of producing nattokinase, i.e. Bacillus subtilis natto ST-1086, deposited at the China General Microbiological Culture Collection Center under CGMCC No. 17895. The present invention further involves a method for producing a nattokinase product by means of using the novel strain CGMCC No. 17895 of the present application, wherein the resulting nattokinase product can be used as a drug for dissolving thrombi. The present invention further involves the use of the nattokinase product of the present application for preparing a composition for dissolving thrombi and in a method for treating thrombi.

Abstract: A fluorinated, alkoxysilyl-functional polymer is provided, obtainable by a method comprising the steps of: a) reacting an OH-functional (per)fluoropolyether (PFPE) with a polyisocyanate A under urethane formation reaction conditions, to obtain an isocyanate-functional intermediate B, b) reacting intermediate B with a secondary, alkoxysilyl-functional monoamine C, to obtain the alkoxysilyl-functional polymer. The polymer can be used as an additive in preparation of a coating with easy-clean, anti-stain and anti-scratch properties, which can advantageously be used for coating various substrates in consumer electronics or automotive applications such as glass, metal, metal alloy, anodized substrates, plastics, composite etc.

Abstract: A cutter is configured to be mounted to a push rod of a caulking gun. The push rod includes a pushing portion for pushing a container containing a caulking material and a rear end portion opposite to the pushing portion. The cutter includes: an assembling portion, configured to be mounted at the rear end portion of the push rod; and a cutting portion, connected with the assembling portion and including a cutting member. A caulking gun including the cutter is further provided.

Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.

Abstract: The invention relates to a fluorinated, alkoxysilyl-functional polymer, obtainable by a method comprising the steps of: a) reacting an OH-functional (per)fluoropolyether (PFPE) with a polyisocyanate A under urethane formation reaction conditions, to obtain an isocyanate-functional intermediate B, b) reacting intermediate B with a secondary, alkoxysilyl-functional monoamine C, to obtain the alkoxysilyl-functional polymer. The polymer can be used as an additive in preparation of a coating with easy-clean, anti-stain and anti-scratch properties, which can advantageously be used for coating various substrates in consumer electronics or automotive applications such as glass, metal, metal alloy, anodized substrates, plastics, composite etc.

Abstract: A cutter and a caulking gun having the same are provided. The cutter is configured to be connected to a caulking gun having a connecting member which is disposed on the caulking gun and includes a first assembling portion. The cutter includes a main body including a base and a cutting portion connected with the base, the cutting portion includes a cutting blade, and the base includes a second assembling portion configured to be detachably connected with the first assembling portion.

Abstract: This application relates to a resource scheduling method, a resource scheduling system, a server, and a storage medium. The resource scheduling method includes receiving a virtual machine application request sent by a terminal, wherein the virtual machine application request includes a target virtual machine label. The resource scheduling method further includes comparing the target virtual machine label with a current virtual machine label of each host computer in a cluster to determine a target host computer, wherein the target host computer includes no virtual machine label matching the target virtual machine label, enabling the target host computer to create a first virtual machine, and setting a label of the first virtual machine as the target virtual machine label.

Abstract: A cutter is configured to be mounted to a push rod of a caulking gun. The push rod includes a pushing portion for pushing a container containing a caulking material and a rear end portion opposite to the pushing portion. The cutter includes: an assembling portion, configured to be mounted at the rear end portion of the push rod; and a cutting portion, connected with the assembling portion and including a cutting member. A caulking gun including the cutter is further provided.

Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.

Abstract: Provided is a Bacillus subtilis natto strain ST-1008, deposited under the accession number CGMCC No. 17894. Also provided is a method for producing MK-7. The method comprises: culturing the Bacillus subtilis natto strain of CGMCC No. 17894 in a culture medium so as to produce MK-7 in the strain cell and the culture medium, and recovering and purifying MK-7 from the strain cell and the culture medium. Also provided are a MK-7 preparation, a MK-7 pure premix, and a pure MK-7.

Abstract: Disclosed are a strain for producing nattokinase and a production method therefor. In particular, the present invention involves a novel strain capable of producing nattokinase, i.e. Bacillus subtilis natto ST-1086, deposited at the China General Microbiological Culture Collection Center under CGMCC No. 17895. The present invention further involves a method for producing a nattokinase product by means of using the novel strain CGMCC No. 17895 of the present application, wherein the resulting nattokinase product can be used as a drug for dissolving thrombi. The present invention further involves the use of the nattokinase product of the present application for preparing a composition for dissolving thrombi and in a method for treating thrombi.

Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.

Abstract: Provided are a method for extracting a hirudin mutant, HV2-Lys47, from a fermentation broth of the hirudin mutant HV2-Lys47 produced by the fermentation of Escherichia coli, and purifying same, the use of the hirudin mutant HV2-Lys47 in an anticoagulated blood collection tube, and an anticoagulated blood collection tube containing the hirudin mutant HV2-Lys47. In the purification method, a membrane technology and a primary column chromatography technology are used to obtain the hirudin mutant HV2-Lys47.

Abstract: Disclosed herein are novel synthetic polypeptides and uses thereof in the preparation of liposomes. According to embodiments of the present disclosure, the synthetic polypeptide comprises a membrane lytic motif, a masking motif, and a linker configured to link the membrane lytic motif and the masking motif. The linker is cleavable by a stimulus, such as, light, protease, or phosphatase. Once being coupled to a liposome, the exposure to the stimulus cleaves the linker that results in the separation of the masking motif from the membrane lytic motif, which in turn exerts membrane lytic activity on the liposome that leads to the collapse of the intact structure of the liposome, and releases the agent encapsulated in the liposome to the target site. Also disclosed herein are methods of diagnosing or treating a disease in a subject by use of the present liposomes.

Abstract: This application relates to a resource scheduling method, a resource scheduling system, a server, and a storage medium. The resource scheduling method includes receiving a virtual machine application request sent by a terminal, wherein the virtual machine application request includes a target virtual machine label. The resource scheduling method further includes comparing the target virtual machine label with a current virtual machine label of each host computer in a cluster to determine a target host computer, wherein the target host computer includes no virtual machine label matching the target virtual machine label, enabling the target host computer to create a first virtual machine, and setting a label of the first virtual machine as the target virtual machine label.

Abstract: A method for optimizing manufacturability of standard cells includes generating random contexts for the standard cells, inserting vias into the standard cells, and performing a lithography verification on the standard cells after the vias have been inserted. The method enables early detection and resolution of potential hot spots on standard cell pin connections and reduction of hot spots that are introduced by the router at the chip level. The early detection and reduction of hot spots shortens the cycle time of a standard-cell based design.

Abstract: The present invention provides a control system for managing lubricant levels in tandem compressor assemblies of a heating, ventilation, and air conditioning (HVAC) system. In transitioning from a partial load that operates a first compressor but not a second compressor of a tandem assembly to a full load that operates both the first and the second compressor, a controller of the HVAC system turns OFF both compressors of the tandem compressor assembly to allow time for lubricant levels to equalize between the first and the second compressor.

Abstract: The present invention discloses a stepwise refinement detection method for pavement cracks, processing pavement images comprising the following primary steps: extracting and processing marking lines, extracting ROA, adaptive threshold segmentation based on ROA, extracting ROC and region growth based on ROC direction feature weighting.