Patents by Inventor Lin-Hsiang CHUANG
Lin-Hsiang CHUANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11739044Abstract: The present invention relates to a method for synthesizing artepillin C and a synthetic method for synthesizing an intermediate compound for use in preparing artepillin C. The structural formula of artepillin C is shown in the following formula (IV), and the intermediate compound is shown in the following formula (II). The synthesis method includes the following steps: a first reaction step: in the presence of a base initiator, a compound A shown in formula I and 3,3-dimethylallyl bromide are mixed, the reaction continues for a first reaction time and is stopped to generate an intermediate of artepillin C shown in formula II; and a second reaction step: the intermediate of artepillin C is dissolved in an aqueous alcohol solution and then mixed with an alkali metal salt, and the reaction continues for a second reaction time to generate artepillin C.Type: GrantFiled: February 23, 2021Date of Patent: August 29, 2023Assignee: GWO XI STEM CELL APPLIED TECHNOLOGY CO., LTD.Inventors: Ming-Hsi Chuang, Lin-Hsiang Chuang, Ming-Hsuan Lu, Wen-Peng Shen, Yun-Chen Lin, Chi-Hsuan Chuang
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Publication number: 20230159889Abstract: Uses of n-butylidenephthalide (BP) in dopaminergic progenitor cell transplantation are provided, wherein the uses include using BP to enhance the therapeutic effect of dopaminergic progenitor cell transplantation, and using a combination of BP and BP-treated dopaminergic progenitor cells in dopaminergic progenitor cell transplantation. The uses especially relate to using BP to enhance the therapeutic effect of dopaminergic progenitor cell transplantation on Parkinson’s disease.Type: ApplicationFiled: January 26, 2023Publication date: May 25, 2023Inventors: MING-HSI CHUANG, LIN-HSIANG CHUANG, PO-CHENG LIN, CHIA-HSIN LEE, YI-CHUN LIN, CHI-HSUAN CHUANG, SHINN-ZONG LIN, CHIA-YU CHANG, CHING-I SHEN
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Publication number: 20220098139Abstract: The present invention relates to a method for synthesizing artepillin C and a synthetic method for synthesizing an intermediate compound for use in preparing artepillin C. The structural formula of artepillin C is shown in the following formula (IV), and the intermediate compound is shown in the following formula (II). The synthesis method includes the following steps: a first reaction step: in the presence of a base initiator, a compound A shown in formula I and 3,3-dimethylallyl bromide are mixed, the reaction continues for a first reaction time and is stopped to generate an intermediate of artepillin C shown in formula II; and a second reaction step: the intermediate of artepillin C is dissolved in an aqueous alcohol solution and then mixed with an alkali metal salt, and the reaction continues for a second reaction time to generate artepillin C.Type: ApplicationFiled: February 23, 2021Publication date: March 31, 2022Inventors: Ming-Hsi Chuang, Lin-Hsiang Chuang, Ming-Hsuan Lu, Wen-Peng Shen, Yun-Chen Lin, Chi-Hsuan Chuang
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Publication number: 20200063098Abstract: Uses of n-butylidenephthalide (BP) in dopaminergic progenitor cell transplantation are provided, wherein the uses include using BP to enhance the therapeutic effect of dopaminergic progenitor cell transplantation, and using a combination of BP and BP-treated dopaminergic progenitor cells in dopaminergic progenitor cell transplantation. The uses especially relate to using BP to enhance the therapeutic effect of dopaminergic progenitor cell transplantation on Parkinson's disease.Type: ApplicationFiled: November 8, 2018Publication date: February 27, 2020Inventors: Ming-Hsi CHUANG, Lin-Hsiang CHUANG, Po-Cheng LIN, Chia-Hsin LEE, Yi-Chun LIN, Chi-Hsuan CHUANG, Shinn-Zong LIN, Chia-Yu CHANG, Ching-I SHEN
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Patent number: 10214719Abstract: A method of culturing Antrodia cinnamomea with high Triterpenoids includes mixing a malt extract, glucose, peptone, agar, and a mushroom's extract with distilled water to obtain a culture medium; providing the culture medium to a high-pressure sterilization machine for sterilization to obtain a sterilized culture medium; providing the sterilized culture medium to an incubator in a disinfection environment to obtain a solidified culture medium after a predetermined time; transplanting Antrodia cinnamomeas strains to the solidified culture medium at separated positions; and exposing the solidified culture medium under a beam.Type: GrantFiled: August 14, 2017Date of Patent: February 26, 2019Assignee: Ultra-Microrigin Biomedical Technology Co., Ltd.Inventors: Ming-Hsi Chuang, Chu-Ting Liu, I-Lung Yu, Lin-Hsiang Chuang
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Publication number: 20170342369Abstract: A method of culturing Antrodia cinnamomea with high Triterpenoids includes mixing a malt extract, glucose, peptone, agar, and a mushroom's extract with distilled water to obtain a culture medium; providing the culture medium to a high-pressure sterilization machine for sterilization to obtain a sterilized culture medium; providing the sterilized culture medium to an incubator in a disinfection environment to obtain a solidified culture medium after a predetermined time; transplanting Antrodia cinnamomeas strains to the solidified culture medium at separated positions; and exposing the solidified culture medium under a beam.Type: ApplicationFiled: August 14, 2017Publication date: November 30, 2017Inventors: Ming-Hsi Chuang, Chu-Ting Liu, I-Lung Yu, Lin-Hsiang Chuang
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Patent number: 9751956Abstract: A method of using supercritical fluid technology to separate and purify the functional components of Antrodia cinnamomea is described. Triterpenoids and polysaccharides of Antrodia cinnamomea are extracted from a fractionation tank containing extract of Antrodia cinnamomea and supercritical solvent at a set temperature and pressure. The extracted functional components and supercritical solvent are then continuously fed into three separating tanks at a set temperature and a pressure below that of the aforesaid pressure to obtain various functional components of triterpenoids and polysaccharides from the Antrodia cinnamomea feed in each separating tank.Type: GrantFiled: August 18, 2015Date of Patent: September 5, 2017Assignee: ULTRA-MICRORIGIN BIOMEDICAL TECHNOLOGY CO., LTD.Inventors: Ming-Hsi Chuang, Chu-Ting Lin, I-Lung Yu, Lin-Hsiang Chuang
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Publication number: 20170159008Abstract: A method of culturing Antrodia cinnamomea with high Triterpenoids includes mixing a malt extract, glucose, peptone, agar, and a mushroom extract with distilled water to obtain a culture medium; providing the culture medium to a high-pressure sterilization machine for sterilization to obtain a sterilized culture medium; providing the sterilized culture medium to an incubator in a disinfection environment to obtain a solidified culture medium after a predetermined time; transplanting Antrodia cinnamomeas strains to the solidified culture medium at separated positions; and exposing the solidified culture medium under a beam.Type: ApplicationFiled: March 15, 2016Publication date: June 8, 2017Inventors: Ming-Hsi Chuang, Chu-Ting Liu, I-Lung Yu, Lin-Hsiang Chuang
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Patent number: 9567365Abstract: The present invention provides a method of separating estrogen from placenta, which uses supercritical fluid technique to load the placenta powder of human body or sheep, pig, deer and other animals into an extraction tank. Under the operating conditions of preset pressure and temperature, supercritical solvent is added into the extraction tank to extract estrogen from placenta, so as to acquire de-estrogen placenta powder and placenta extract liquor. Under the same condition, the de-estrogen placenta extract liquor and supercritical solvent are added by a preset volume flow ratio into an adsorption tank. The estrogen in the placenta extract liquor is adsorbed by the adsorption tank to obtain de-estrogen placenta extract. It is then eluted with ethanol solution by gradient proportion to obtain purified natural estrogen.Type: GrantFiled: February 9, 2016Date of Patent: February 14, 2017Assignees: SUPER WELL BIOTECHNOLOGY CORPORATION, ULTRA-MICRORIGIN BIOMEDICAL TECHNOLOGY CO., LTD.Inventors: Zer-Ran Yu, Be-Jen Wang, Shu-Mei Lin, Hua-Ching Lin, Ming-Hsi Chuang, Chu-Ting Liu, Chiu-Ying Peng, Lin-Hsiang Chuang
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Publication number: 20160257768Abstract: A method of using supercritical fluid technology to separate and purify the functional components of Antrodia cinnamomea is described. Triterpenoids and polysaccharides of Antrodia cinnamomea are extracted from a fractionation tank containing extract of Antrodia cinnamomea and supercritical solvent at a set temperature and pressure. The extracted functional components and supercritical solvent are then continuously fed into three separating tanks at a set temperature and a pressure below that of the aforesaid pressure to obtain various functional components of triterpenoids and polysaccharides from the Antrodia cinnamomea feed in each separating tank.Type: ApplicationFiled: August 18, 2015Publication date: September 8, 2016Inventors: Ming-Hsi Chuang, Chu-Ting Lin, I-Lung Yu, Lin-Hsiang Chuang
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Publication number: 20160159847Abstract: The present invention provides a method of separating estrogen from placenta, which uses supercritical fluid technique to load the placenta powder of human body or sheep, pig, deer and other animals into an extraction tank. Under the operating conditions of preset pressure and temperature, supercritical solvent is added into the extraction tank to extract estrogen from placenta, so as to acquire de-estrogen placenta powder and placenta extract liquor. Under the same condition, the de-estrogen placenta extract liquor and supercritical solvent are added by a preset volume flow ratio into an adsorption tank. The estrogen in the placenta extract liquor is adsorbed by the adsorption tank to obtain de-estrogen placenta extract. It is then eluted with ethanol solution by gradient proportion to obtain purified natural estrogen.Type: ApplicationFiled: February 9, 2016Publication date: June 9, 2016Inventors: Zer-Ran YU, Be-Jen WANG, Shu-Mei LIN, Hua-Ching LIN, Ming-Hsi CHUANG, Chu-Ting LIU, Chiu-Ying PENG, Lin-Hsiang CHUANG
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Publication number: 20160074773Abstract: The present invention provides a method to separate and purify functional ingredients in placenta using supercritical fluid technology, where, placenta extract liquid and supercritical CO2 solvent are guided into a fractionation tank constantly in a preset velocity at a preset temperature and pressure to extract peptides, proteins and other functional ingredients. And then, the solution is conveyed through the three fractionation tanks at a preset temperature and depressurized gradually to separate, fractionate and purify the content of placenta peptide and protein, so as to obtain the high purity of peptides, proteins, active factors and other functional ingredients.Type: ApplicationFiled: May 1, 2015Publication date: March 17, 2016Inventors: Zer-Ran YU, Be-Jen WANG, Shu-Mei LIN, Hua-Ching LIN, Ming-Hsi CHUANG, Chu-Ting LIU, I-Lung YU, Chiu-Ying PENG, Lin-Hsiang CHUANG
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Publication number: 20160051591Abstract: The present invention provides a method for the separation of placenta functional ingredients. By using the supercritical fluid technology, the placenta powder is placed inside an extraction tank, under the predetermined pressure and temperature; the supercritical CO2 solvent is flown into the adsorption tank, in order to deodorize the fishy smell of the placenta powder, and extract the oil of the placenta powder. Under the same operating conditions as mentioned above, the deodorized and extracted placenta powder and supercritical CO2/ethanol solvents are flown into an adsorption tank at the predetermined volumetric flow rate ratio to adsorb the estrogen of placenta powder to get the estrogen-removed placenta peptide extracts. Afterwards, supercritical CO2/ethanol solvents are separated by rapid decompression to get the functional ingredients of placenta powder.Type: ApplicationFiled: May 1, 2015Publication date: February 25, 2016Inventors: Zer-Ran YU, Be-Jen WANG, Tsao-Chen WEI, Hua-Ching LIN, Ming-Hsi CHUANG, Chu-Ting LIU, I-Lung YU, Chiu-Ying PENG, Lin-Hsiang CHUANG
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Publication number: 20150274769Abstract: The present invention provides a method of separating estrogen from placenta, which uses supercritical fluid technique to load the placenta powder of human body or sheep, pig, deer and other animals into an extraction tank. Under the operating conditions of preset pressure and temperature, supercritical solvent is added into the extraction tank to extract estrogen from placenta, so as to acquire de-estrogen placenta powder and placenta extract liquor. Under the same condition, the de-estrogen placenta extract liquor and supercritical solvent are added by a preset volume flow ratio into an adsorption tank. The estrogen in the placenta extract liquor is adsorbed by the adsorption tank to obtain de-estrogen placenta extract. It is then eluted with ethanol solution by gradient proportion to obtain purified natural estrogen.Type: ApplicationFiled: June 10, 2014Publication date: October 1, 2015Inventors: Zer-Ran YU, Be-Jen WANG, Shu-Mei LIN, Hua-Ching LIN, Ming-Hsi CHUANG, Chu-Ting LIU, Chiu-Ying PENG, Lin-Hsiang CHUANG