Abstract: A microbubble counting method for patent foramen ovale (PFO) based on deep learning is provided. The method includes: segmenting a target area of a left heart in an ultrasonic image; and generating a corresponding density map for a segmented target image using a convolutional neural network (CNN), and calculating a total number of the microbubbles in the segmented area by integration and summation. The method has the following beneficial effects: target segmentation is performed on the left atrium and left ventricular area of the heart using the neural network, and effective segmentation of the target area of the left heart is the key of obtaining parameters such as a size and form of the target area. The target area is quantitatively analyzed according to a segmentation result, and the number of the microbubbles in the target area is counted.

Abstract: There are provided compounds of Formula (A) and pharmaceutically acceptable salts and esters thereof, and pharmaceutical compositions thereof, used for the prevention or treatment in a mammal of joint and bone disorders such as arthritis and osteoporosis.

Abstract: A control method of a three-phase multi-level inverter includes: determining a modulation ratio based on output of the three-phase multi-level inverter, where the modulation ratio indicates a ratio of an amplitude value of a sinusoidal modulation wave in pulse width modulation to an amplitude value of a carrier; generating, based on the modulation ratio and a modulation ratio threshold, a common-mode voltage regulation signal for regulating a common-mode voltage in phase voltages of the three-phase multi-level inverter; adding the common-mode voltage regulation signal and a differential-mode voltage regulation signal for regulating a differential-mode voltage in the phase voltages of the three-phase multi-level inverter to obtain a composite regulation signal, where the composite regulation signal is presented as a modulation wave for discontinuous pulse width modulation (DPWM); and generating, based on the composite regulation signal, drive signals for controlling switches of phases of the three-phase multi-

Abstract: A two-photon stimulated emission depletion composite microscope, comprising a two-photon imaging unit (100) and an STED imaging unit (200), wherein the two-photon imaging unit (100) can be used for a relatively thick sample, and the STED super-resolution imaging unit can be used for a region of interest on a surface of a sample, and the microscope makes light spots generated by an excitation light and a depletion light after being focused by an objective lens (OL) accurately coincide in a three-dimensional distribution. The two-photon stimulated emission depletion composite microscope (10) integrates two functions of STED imaging and two-photon imaging and makes the two types of light spots generated by an excitation light and a depletion light after being focused by an objective lens accurately coincide in a three-dimensional distribution, thereby providing a powerful tool for cutting-edge biomedical research.

Abstract: A STED super-resolution microscope capable of quick beam combination is disclosed, which includes a STED imaging unit and a beam combination test unit. The excitation light and the depletion light are accurately combined by the beam combination test unit, so that the imaging light spots of the two light beams passing through the STED imaging unit can accurately coincide with each other, thereby obtaining a better super-resolution imaging effect.

Abstract: A method of treating a subject having a cancer comprising administering a tumor suppressor therapy, such as a TUSC2 therapy, in conjunction with an immune checkpoint inhibitor. Kits and reagents for use in cancer therapy are also provided.

Abstract: A method of treating a subject having a cancer comprising administering a tumor suppressor therapy, such as a TUSC2 therapy, in conjunction with an immune checkpoint inhibitor. Kits and reagents for use in cancer therapy are also provided.

Abstract: A two-photon stimulated emission depletion composite microscope, comprising a two-photon imaging unit (100) and an STED imaging unit (200), wherein the two-photon imaging unit (100) can be used for a relatively thick sample, and the STED super-resolution imaging unit can be used for a region of interest on a surface of a sample, and the microscope makes light spots generated by an excitation light and a depletion light after being focused by an objective lens (OL) accurately coincide in a three-dimensional distribution. The two-photon stimulated emission depletion composite microscope (10) integrates two functions of STED imaging and two-photon imaging and makes the two types of light spots generated by an excitation light and a depletion light after being focused by an objective lens accurately coincide in a three-dimensional distribution, thereby providing a powerful tool for cutting-edge biomedical research.

Abstract: A two-photon stimulated emission depletion composite microscope using continuous light loss, the microscope comprising: a two-photon imaging unit (100) and an STED imaging unit (200), wherein for thicker samples, the two-photon imaging unit (100) can be used, and for regions of interest on the surface of samples, the STED super-resolution imaging unit (200) can be used. The two-photon stimulated emission depletion composite microscope using continuous light loss integrates two functions of STED imaging and two-photon imaging, so as to provide a powerful tool for cutting-edge biomedical research.

Abstract: Disclosed is a STED super-resolution microscope capable of quick beam combination, which includes a STED imaging unit and a beam combination test unit. The excitation light and the depletion light are accurately combined by the beam combination test unit, so that the imaging light spots of the two light beams passing through the STED imaging unit can accurately coincide with each other, thereby obtaining a better super-resolution imaging effect.

Abstract: An electric motor having a frame, a rotor assembly, and a stator assembly. The rotor assembly has a magnet, a bearing assembly, an impeller, and a shaft. The bearing assembly has a first bearing, a second bearing, and a biasing element between the first and second bearings. The first bearing is mounted to the frame by an o-ring, and the second bearing is mounted to the frame by adhesive.

Abstract: A method of treating a subject having a cancer comprising administering a tumor suppressor therapy, such as a TUSC2 therapy, in conjunction with an immune checkpoint inhibitor. Kits and reagents for use in cancer therapy are also provided.

Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.

Abstract: A method of manufacturing a footwear sole includes providing a base sole, and performing an electrostatic flocking process to bond a leather material layer onto a portion of the base sole. The electrostatic flocking process includes the steps of applying an adhesive material to cover a surface of the base sole, providing a leather flock source, spraying electrically charged leather flock onto the adhesive covered surface of the base sole, and curing the base sole to bond the leather flock to the surface of the base sole. The method is described principally with respect to applying a leather material layer to a surface of a base sole, and the method may be employed to apply a leather material layer to shoe portions other than a surface of the base sole, such as a surface of the outer sole, insole, or inner sole, or a surface of a whole shoe.

Abstract: A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that facilitates cellular uptake of the protein. The polypeptide can be a protein or a peptide. In some embodiments, the amino acid sequence of the protein or peptide is derived from the amino acid sequence of a tumor suppressor gene product.

Abstract: A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that facilitates cellular uptake of the protein. The polypeptide can be a protein or a peptide. In some embodiments, the amino acid sequence of the protein or peptide is derived from the amino acid sequence of a tumor suppressor gene product.

Abstract: A nanoparticle-polypeptide complex comprising a bioactive polypeptide in association with a nanoparticle, wherein the bioactive polypeptide is modified by the addition of a chemical moiety that facilitates cellular uptake of the protein. The polypeptide can be a protein or a peptide. In some embodiments, the amino acid sequence of the protein or peptide is derived from the amino acid sequence of a tumor suppressor gene product.

Abstract: A method for implementing the subscriber port positioning by broadband access equipments, includes: when the subscriber initiates an access request, the multi-port terminal equipment captures the access request message, adds the subscriber basic information into the access request message, and transmits it to the office equipment; the single-port terminal equipment forwards the access request message to the office equipment directly; the office equipment captures the access request message, adds the terminal basic information into the access request message and forwards it to the broadband access server; for the multi-port terminal equipment, the terminal basic information and the subscriber basic information comprises the subscriber port positioning information; for the single-port terminal equipment, the terminal basic information is taken as the subscriber port positioning information; after the broadband access server receives the access request message, it extracts the subscriber port positioning informa

Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.

Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.