Abstract: An optimization method of shield tunnel starting end reinforcement solution, which specifically includes the following steps: acquiring shield tunnel engineering data and temperature variation curves of thermometer holes; constructing a numerical model with thermal convection and a hydro-thermal coupling numerical model respectively according to the shield tunnel engineering data, wherein a first temperature variation curve and a second temperature variation curve can be obtained after carrying out numerical simulations on the above two models; the influence of seepage on the development law of a temperature field can be obtained by comparing and analyzing the temperature variation curves of the thermometer holes with the first and the second temperature variation curves; and finally the existing freezing solution of the shield tunnel is optimized according to the influence of the seepage on the development law of the temperature field, to ensure safe use of the shield tunnel.

Abstract: There is provided a device for editing a PDF file, including a display, a non-volatile storage medium, a memory and a processor. The non-volatile storage medium stores a computer program. The memory provides an environment for operations of the computer program in the non-volatile storage medium. The processor runs the computer program to parse the PDF file to obtain information of characters, generate character sets according to features of the characters, generate line sets according to heights and horizontal positions of the character sets, generate paragraph sets according to a height and a horizontal position of each line of the line sets, generate text region sets according a height and a horizontal position of each paragraph of the paragraph sets, and control the display to show the text region sets in the PDF file as editable text regions.

Abstract: A method for treating a tumor or cancer by means of a treatment scheme of using endostatin in combination with induction of DNA double-strand breaks, and a medication. The method and composition are used for treating a tumor or cancer related to loss of p53 function, or a tumor or cancer occurring when p53 function is normal.

Abstract: Provided is an optimization method of shield tunnel starting end reinforcement solution, which specifically includes the following steps: acquiring shield tunnel engineering data and temperature variation curves of thermometer holes; constructing a numerical model with thermal convection and a hydro-thermal coupling numerical model respectively according to the shield tunnel engineering data, wherein a first temperature variation curve and a second temperature variation curve can be obtained after carrying out numerical simulations on the above two models; the influence of seepage on the development law of a temperature field can be obtained by comparing and analyzing the temperature variation curves of the thermometer holes with the first and the second temperature variation curves; and finally the existing freezing solution of the shield tunnel is optimized according to the influence of the seepage on the development law of the temperature field, to ensure safe use of the shield tunnel.

Abstract: The present invention discloses an equal energy deformation composite foundation using microorganism to solidify aggregate and a construction method thereof, the composite foundation comprises a pile body and a cushion layer, wherein the pile body is provided with several piles, the cushion layer is arranged at the top of the pile body, the pile body is connected into an integral structure through the cushion layer, and the pile body and the cushion layer are filled with aggregate solidified by microorganism. The method comprises the following steps: step 1, leveling the site; Step 2, construction preparation; Step 3, the pile driver in place; Step 4, forming a hole by hammering; Step 5, filling aggregate into the hole; Step 6, repeating the work of step 5; Step 7, forming an equal energy deformation compaction pile using microorganism to solidify aggregate; Step 8, moving to the next pile; Step 9, tamping the ground; Step 10, until the cushion is flush with the surface.

Abstract: The present invention provides electronic systems, including device arrays, comprising functional device(s) and/or device component(s) at least partially enclosed via one or more containment chambers, such that the device(s) and/or device component(s) are at least partially, and optionally entirely, immersed in a containment fluid. Useful containment fluids for use in containment chambers of electronic devices of the invention include lubricants, electrolytes and/or electronically resistive fluids. In some embodiments, for example, electronic systems of the invention comprise one or more electronic devices and/or device components provided in free-standing and/or tethered configurations that decouple forces originating upon deformation, stretching or compression of a supporting substrate from the free standing or tethered device or device component.

Abstract: A method for treating a tumor or cancer by means of a treatment scheme of using endostatin in combination with induction of DNA double-strand breaks, and a medication. The method and composition are used for treating a tumor or cancer related to loss of p53 function, or a tumor or cancer occurring when p53 function is normal.

Abstract: The present invention provides electronic systems, including device arrays, comprising functional device(s) and/or device component(s) at least partially enclosed via one or more fluid containment chambers, such that the device(s) and/or device component(s) are at least partially, and optionally entirely, immersed in a containment fluid. Useful containment fluids for use in fluid containment chambers of electronic devices of the invention include lubricants, electrolytes and/or electronically resistive fluids. In some embodiments, for example, electronic systems of the invention comprise one or more electronic devices and/or device components provided in free-standing and/or tethered configurations that decouple forces originating upon deformation, stretching or compression of a supporting substrate from the free standing or tethered device or device component.

Abstract: The present invention provides a method for inhibiting lymphangiogenesis in a subject, comprising administering a therapeutically effective amount of a CXCR4 inhibitor and/or a CXCL12 inhibitor to the subject. The invention further provides a method for inhibiting tumor lymphatic metastasis in a cancer patient, comprising administering to the subject (a) a therapeutically effective amount of a CXCR4 inhibitor and/or a CXCL12 inhibitor, in combination with (b) a therapeutically effective amount of a VEGF-C inhibitor and/or a VEGF-D inhibitor and/or a VEGFR-3 inhibitor.

Abstract: The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents.

Abstract: The present invention provides electronic systems, including device arrays, comprising functional device(s) and/or device component(s) at least partially enclosed via one or more containment chambers, such that the device(s) and/or device component(s) are at least partially, and optionally entirely, immersed in a containment fluid. Useful containment fluids for use in containment chambers of electronic devices of the invention include lubricants, electrolytes and/or electronically resistive fluids. In some embodiments, for example, electronic systems of the invention comprise one or more electronic devices and/or device components provided in free-standing and/or tethered configurations that decouple forces originating upon deformation, stretching or compression of a supporting substrate from the free standing or tethered device or device component.

Abstract: 2-pattern photonic crystal and the associated photonic devices are described here. A 2-pattern photonic crystal has a large, complete photonic band gap. It includes a TM sub-structure providing a large TM photonic band gap superimposed on a TE sub-structure providing a large TE photonic band gap. The resulting 2-pattern photonic crystals have complete photonic band gaps larger than 15%. By altering the respective sub-structures, optical devices for different polarizations (TE, TM or both) can be readily designed, and those optical devices can be integrated on the same plane.

Abstract: The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents.

Abstract: The present invention provides a method for inhibiting lymphangiogenesis in a subject, comprising administering a therapeutically effective amount of a CXCR4 inhibitor and/or a CXCL12 inhibitor to the subject. The invention further provides a method for inhibiting tumor lymphatic metastasis in a cancer patient, comprising administering to the subject (a) a therapeutically effective amount of a CXCR4 inhibitor and/or a CXCL12 inhibitor, in combination with (b) a therapeutically effective amount of a VEGF-C inhibitor and/or a VEGF-D inhibitor and/or a VEGFR-3 inhibitor.

Abstract: The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents.

Abstract: 2-pattern photonic crystal and the associated photonic devices are described here. A 2-pattern photonic crystal has a large, complete photonic band gap. It includes a TM sub-structure providing a large TM photonic band gap superimposed on a TE sub-structure providing a large TE photonic band gap. The resulting 2-pattern photonic crystals have complete photonic band gaps larger than 15%, By altering the respective sub-structures, optical devices for different polarizations (TE, TM or both) can be readily designed, and those optical devices can be integrated on the same plane.

Abstract: A no-stop electronic toll collection (ETC) system based on WLAN is disclosed in the present invention. The system includes an on-board equipment, roadside equipments, a multiple access carriageway control system and a toll balance center. The communication is implemented between the on-board equipment and the roadside equipments according to the demand determined by the wireless local network protocol. The system offered in the present invention applies several technology means to effectively overcome the technology prejudice that the WLAN technology is not suitable for the ETC system. Compared with the existing technology, the present ETC system has the advantages of low cost, high efficiency, complete function and good performance index, therefore the present invention is very meaningful for the application and extension of the ETC system and the improvement of the industrial technology.

Abstract: A no-stop electronic toll collection (ETC) system based on WLAN is disclosed in the present invention. The system includes an on-board equipment, roadside equipments, a multiple access carriageway control system and a toll balance center. The communication is implemented between the on-board equipment and the roadside equipments according to the demand determined by the wireless local network protocol. The system offered in the present invention applies several technology means to effectively overcome the technology prejudice that the WLAN technology is not suitable for the ETC system. Compared with the existing technology, the present ETC system has the advantages of low cost, high efficiency, complete function and good performance index, therefore the present invention is very meaningful for the application and extension of the ETC system and the improvement of the industrial technology.

Abstract: A manufacturing execution system determines production rates of tool elements of a manufacturing system and from the production rates, the efficiency of the tool elements and the efficiency of the manufacturing process system. The manufacturing execution system is in communication with a plurality of tool elements of the manufacturing process system. The manufacturing execution system includes a process data collection device, a data retaining device such as a memory, a time recording device, and a production rate calculator. The process data collection device is in communication with sensors located on the tool elements to receive tool element status data. The data retaining device is in communication with the process data collection device to record and retain the tool element status data. The time recording device records times of changes of the tool element status data to the data retaining device.