Abstract: The present invention relates to compounds of formula (I): including any stereochemically isomeric form thereof, or pharmaceutically acceptable salts thereof, for the treatment of, for example, hypercholesterolemia.

Abstract: This invention relates to inhibitory peptides which bind to ?-synuclein molecules and inhibit ?-synuclein amyloidogenic aggregation, ?-synuclein cytotoxicity, and spread of ?-synuclein. Methods of making and using the inhibitory peptides (e.g. to treat subjects having conditions or diseases that are mediated by ?-synuclein, such as Parkinson's disease, dementia with Lewy bodies, or MSA) are described.

Abstract: The present invention provides a Bifidobacterium lactis GKK2, a composition comprising thereof and its use for improving asthma, especially for lowering airway resistance, reducing levels of non-specific and specific IgE in serum, alleviating bronchoconstriction and increasing levels of GSH reductase in liver tissue interstitial fluid to improve allergic asthma.

Abstract: Structures including an optical component and methods of forming a structure including an optical component. The structure includes an optical component on a substrate, and a back-end-of-line stack including multiple metal levels. Each of the metal levels includes a dielectric layer and metal features positioned over the optical component as metal fill in the dielectric layer. The metal features in at least two of the metal levels are arranged to overlap such that the optical component is fully covered normal to the substrate.

Abstract: The invention relates to the field of pharmaceutical chemistry, and it particularly relates to a left-handed bicyclic morpholine and a pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition and use thereof in the preparation of medicaments for preventing and/or treating liver diseases and the like.

Abstract: The invention relates to a single nucleotide polymorphism (SNP) marker related to a Chinese horse short stature trait. The SNP molecular marker is located at the 501th position of a sequence shown in SEQ ID NO.1, polymorphism is G/A, and the SNP marker corresponds to base pair 18,205,998 on chromosome 8 in a horse. The SNP marker related to the Chinese horse short stature trait and use thereof provided by the present invention have the following advantages that: (1) the molecular marker is not restricted by the age, sex and the like of Chinese horses, is used in early breeding of the Chinese horses, performs accurate screening immediately at birth, and significantly promotes the breeding process of dominant pony varieties of the Chinese horse; (2) a method for detecting SNP of a Chinese horse TBX3 gene is accurate, reliable, and easy to operate.

Abstract: A heavy oil lifting device and a heavy oil lifting method are provided. The device includes: a plurality of liquid injection pumps each including a liquid inlet and a liquid outlet and configured to intake in liquid and discharge the liquid after pressurization; a control valve including a first end and a second end, the liquid outlets of the plurality of liquid injection pumps are connected with the first end; a power liquid transmission pipe connected with the second end and configured to transmit the liquid after pressurization; an operation pump connected with the power liquid transmission pipe, and the liquid after pressurization is used as power liquid to drive the operation pump to reciprocate; the control valve is in switchable communication with the liquid injection pump so that the power liquid transmission pipe is in switchable communication with the liquid injection pump.

Abstract: The invention relates to a method, an apparatus and a non-transitory computer-readable storage medium for debugging a solid-state disk (SSD) device. The method is performed by a processing unit of a single-board personal computer (PC) when loading and executing a function of a runtime library, to include: receiving a request to drive a General-Purpose Input/Output (GPIO) interface (I/F), which includes a parameter required for completing a Joint Test Action Group (JTAG) command; issuing a first hardware instruction to the GPIO I/F to set a register corresponding to a GPIO test data input (TDI) pin according to the parameter carried in the request for emulating to issue the JTAG command to a solid-state disk (SSD) device, wherein the single-board PC is coupled to the SSD device through the GPIO I/F; issuing a second hardware instruction to the GPIO I/F to read a value of the register corresponding to the GPIO TDI pin; and replying with a completion message in response to the request.

Abstract: A method, a system, and a computer program product for detecting fake news based on a multi-task learning model. In an embodiment, a multi-task learning model is used to perform joint training on authenticity detection and topic classification of news to be detected, and authenticity of the news to be detected and a topic of the news to be detected are returned simultaneously. Through the implementation of the embodiment of the present invention, the authenticity of the news and the topic of the news can be detected simultaneously, and the accuracy of fake news detection and topic classification is improved.

Abstract: A method, apparatus and system for transmitting data. The system includes: the load balance gate wall translating a virtual MAC address of the virtual server in a destination address of a data packet from a client to a real MAC address of the real server according to a pre-configured address mapping relationship between a real server and a virtual server; the load balance gate wall sending a modified data packet to the virtual switch; the virtual switch determining a data packet flowing into the real server after receiving the data packet from the load balance gate wall, then translating a virtual IP and a virtual port of the virtual server in the destination address in the determined data packet to a real IP and a real port of the real server; and the virtual switch sending the modified data packet to the real server.

Abstract: This document describes techniques and apparatuses for supporting web components associated with a document object model (DOM) corresponding to a data file in a web testing environment. A user interaction, relative to a web page or web application from which the DOM is rendered, is monitored in the web testing environment. The monitoring identifies a target element selected by the user that is referenced in a shadow DOM associated with the DOM. One or more parent shadow host elements of the DOM are identified relative to the target element. The one or more shadow host elements define a reduced path, with respect to a tree data structure representing the DOM and the shadow DOM, for linking a document object of the DOM to the target element. Indicia identifying the one or more shadow host elements as linking the document object of the DOM to the target element are recorded.

Abstract: A system is provided that includes: a first load balancing device cluster, the first load balancing device cluster includes a first load balancing device pool and a second load balancing device pool; at least one first switch respectively coupled with each load balancing device in the first load balancing device pool via a routing protocol link; and at least one second switch respectively coupled with each load balancing device in the second load balancing device pool via a routing protocol link, the at least one first switch and the at least one second switch are configured to be able to be connected with the Internet; and one of the first load balancing device pool and the second load balancing device pool is configured as a standby load balancing device pool of the other.

Abstract: A method of constructing an indoor wall corner two-dimensional semantic map based on a robot platform includes controlling, by the master control computer, the robot platform to move indoors, collecting, by the lidar sensor, a distance between an indoor object and the robot platform and a direction angle between the indoor object and the robot platform in real time and transmitting the distance and the direction angle to the master control computer, and obtaining, by the master control computer, an environment grid map and a real-time pose of the robot platform by processing the distance between the indoor object and the robot platform and the direction angle between the indoor object and the robot platform based on Gmapping algorithm; constructing a semantic segmentation data set as a training set on the master control computer and obtaining a predicted non-wall corner semantic label.

Abstract: This invention relates to inhibitory peptides which bind to ?-synuclein molecules and inhibit ?-synuclein amyloidogenic aggregation, ?-synuclein cytotoxicity, and spread of ?-synuclein. Methods of making and using the inhibitory peptides (e.g. to treat subjects having conditions or diseases that are mediated by ?-synuclein, such as Parkinson's disease, dementia with Lewy bodies, or MSA) are described.

Abstract: The present disclosure relates to as external composition for wound healing containing a Lactobacillus fermentation product, which comprises a Lactobacillus fermentation product as an effective component. The Lactobacillus fermentation product is a bacteria-free concentrated filtrate from fermentation of Lactobacillus plantarum and the effective component is loaded onto a pharmaceutically acceptable absorbent carrier or carrying agent. The external composition for wound healing has anti-inflammatory and healing promoting effects on a skin wound after applied directly onto the skin wound.

Abstract: The present invention provides an active substance of Lactic Acid Bacteria, a composition comprising thereof and its use for promoting longevity, especially for increasing Cisd2 gene expression, reducing mitochondrial damage and delaying aging conditions such as nerve degeneration and sarcopenia.

Abstract: A coherent detection-based high-speed chaotic secure transmission method includes: at a transmit terminal in a chaotic secure transmission system, optically coupling an optical chaotic carrier and transmission information by using an orthogonal basis to mask the transmission information by using a noise-like feature of the chaotic carrier, so as to obtain a chaotic masked signal; adding a fast phase disturbance and a fast polarization disturbance to the chaotic masked signal and transmitting the chaotic masked signal over an optical fiber transmission link; and at a receive terminal, obtaining the chaotic masked signal through coherent detection, compensating the chaotic masked signal for linear and nonlinear effects through digital signal processing, and using a polarization orthogonal basis- or phase orthogonal basis-based chaotic decryption algorithm to separate the chaotic carrier from the signal so as to complete decryption.

Abstract: The hollow body molding aid includes a body, a connector, a first profiling assembly, a second profiling assembly, and a positioning mechanism. The connector is fixedly connected to the body. The first profiling assembly is fixedly disposed on one side of the body and is configured to position one half of a reinforced housing. The second profiling assembly is fixedly disposed on the other side of the body and is configured to position the other half of the reinforced housing. The positioning mechanism is disposed on the first profiling assembly and the second profiling assembly. The reinforced housing can be positioned, thus guaranteeing molding quality of the reinforced housing and blanks. In addition, the reinforced housing can be accurately positioned in a cavity of a mold through a manipulator, without the need to use a plurality of air cylinders for step-by-step driving.

Abstract: In some examples, a system processes event data and video frames produced by a program during execution of the program, the event data representing user actions with respect to a graphical user interface (GUI) of the program. The system identifies an area of the GUI that corresponds to a respective user action of the user actions, wherein identifying the area of the GUI uses a first video frame before an event corresponding to the respective user action, and a second video frame after the event corresponding to the respective user action. The system identifies, based on the identified area, a test object representing a user interface (UI) element, and generates a test script for testing the program, the test script including the test object.

Abstract: An internal support part structure for a plastic tank includes a support rod and end surface components disposed at two ends of the support rod. The support rod is made of a first material. An outer surface of the end surface component is covered by a second material. An outer edge of the end surface component has a regular or irregular shape. The structure resolves a problem that a second material wrapping a first material and connected to an inner wall of a plastic tank may be easily pulled off the inner wall. When a fuel tank is impacted, the support rod of the structure breaks first, to protect the surface of the fuel tank from damage.