Patents by Inventor Lin Jiao

Lin Jiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250213702
    Abstract: A human interleukin 2-polyethylene glycol conjugate and use thereof. The human interleukin 2-polyethylene glycol conjugate comprises a recombinant human interleukin 2 containing at least one unnatural amino acid and PEG coupled to the at least one unnatural amino acid. The unnatural amino acid is a compound containing a carbonyl terminal group and having a structure as shown in formula (I) or an enantiomer thereof, and the PEG is coupled to the at least one unnatural amino acid by forming an oxime bond between the carbonyl terminal group and the PEG containing a hydroxylamine terminal group. The human interleukin 2-polyethylene glycol conjugate can be used individually or in combination with other anti-tumor drugs for the treatment of diseases such as solid tumors and hematologic tumors.
    Type: Application
    Filed: August 24, 2022
    Publication date: July 3, 2025
    Applicant: Novocodex Biopharmaceuticals Co., Ltd.
    Inventors: Xuejun Liang, Chenghao Ye, Gang Xia, Longfei Chen, Pengchao Huo, Jinwei Yang, Yuebin Ying, Zunyang Gong, Xin Heng, Xiaoyu Zhu, Lifei Zhu, Hao Huang, Wen Ding, Lin Jiao, Jingjing Zhu
  • Publication number: 20250213703
    Abstract: The invention provides a human interleukin 2-polyethylene glycol conjugate and use thereof. The human interleukin 2-polyethylene glycol conjugate provided by the invention comprises a recombinant human interleukin 2 containing at least one unnatural amino acid and PEG coupled to the at least one unnatural amino acid. The unnatural amino acid is a compound containing a carbonyl terminal group and having a structure as shown in formula (I) or an enantiomer thereof, and the PEG is coupled to the at least one unnatural amino acid by forming an oxime bond between the carbonyl terminal group and the PEG containing a hydroxylamine terminal group. The human interleukin 2-polyethylene glycol conjugate provided by the invention can be used individually or in combination with other anti-tumor drugs for the treatment of diseases such as solid tumors and hematologic tumors.
    Type: Application
    Filed: March 2, 2022
    Publication date: July 3, 2025
    Applicant: Novocodex Biopharmaceuticals Co., Ltd.
    Inventors: Xuejun LIANG, Chenghao YE, Gang XIA, Longfei CHEN, Pengchao HUO, Jinwei YANG, Yuebin YING, Zunyang GONG, Xin HENG, Xiaoyu ZHU, Lifei ZHU, Hao HUANG, Wen DING, Lin JIAO, Jingjing ZHU
  • Publication number: 20250019711
    Abstract: Provided in the present invention are a method for constructing a strain for producing a recombinant protein containing unnatural amino acids, and the strain obtained therefrom. The method comprises modifying the expression of a prfA gene contained in the strain to be controllable. The strain constructed by the method of the present invention can efficiently produce in intact protein containing unnatural amino acids, greatly reduce the production of a truncated protein and can also maintain high-speed growth.
    Type: Application
    Filed: March 2, 2022
    Publication date: January 16, 2025
    Applicant: Novocodex Biopharmaceuticals Co., Ltd.
    Inventors: Longfei Chen, Lin Jiao, Yuebin Ying, Zunyang Gong, Jingjing Zhu, Xuejun Liang
  • Publication number: 20240317832
    Abstract: An unnatural amino acid may have a structure as shown in formula (1) or may be an enantiomer thereof: Such unnatural amino acid may be used, e.g., in recombinant proteins. A recombinant protein may contain such unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid can be simple and convenient to prepare, safe in nature, difficult to inactivate when inserted into a protein, and may have a high binding rate with a coupling moiety, and the obtained conjugate is higher in stability. The unnatural amino acid is applicable to numerous fields, especially in preparation of a recombinant protein or a recombinant protein conjugate.
    Type: Application
    Filed: July 29, 2021
    Publication date: September 26, 2024
    Applicant: NOVOCODEX BIOPHARMACEUTICALS CO., LTD.
    Inventors: Jinwei YANG, Chenghao YE, Gang XIA, Pengchao HUO, Wen DING, Longfei CHEN, Lin JIAO, Hao HUANG, Xin HENG, Jingjing ZHU, Yuebin YING, Xuejun LIANG
  • Patent number: 10320666
    Abstract: A method and device for processing at least one of routing status and policy information is provided. The method includes: a routing or forwarding system receives a first request for establishing a connection sent by a SDN control client, and the first request carries an identifier of the SDN control client; the routing or forwarding system establishes a corresponding relationship between at least one of routing status and policy information sent by the SDN control client and the identifier; and the routing or forwarding system manages at least one of the routing status and policy information according to the corresponding relationship.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: June 11, 2019
    Assignee: ZTE CORPORATION
    Inventors: Lin Jiao, Chong Feng, Xianxian Dai
  • Publication number: 20180270149
    Abstract: A method and device for processing at least one of routing status and policy information is provided. The method includes: a routing or forwarding system receives a first request for establishing a connection sent by a SDN control client, and the first request carries an identifier of the SDN control client; the routing or forwarding system establishes a corresponding relationship between at least one of routing status and policy information sent by the SDN control client and the identifier; and the routing or forwarding system manages at least one of the routing status and policy information according to the corresponding relationship.
    Type: Application
    Filed: July 2, 2015
    Publication date: September 20, 2018
    Inventors: Lin JIAO, Chong FENG, Xianxian DAI
  • Publication number: 20180172583
    Abstract: This disclosure provides calculation methods for the reflectivity of normal incident wave on the interface, the absolute reflection critical angle of the wave, the relative reflection critical angle of the wave, and the refraction-reflection symmetrical angle of the wave. These calculation methods can calculate the reflected wave energy on interface, the angle at which the incident wave would all be reflected on the interface and wave energy would be trapped, the angle at which the incident wave begins to be reflected, and the angle at which the reflected wave energy equals the refracted wave energy. The provided calculation methods could be widely used in various fields such as light, electromagnetic waves, sound waves and etc.
    Type: Application
    Filed: September 9, 2015
    Publication date: June 21, 2018
    Inventors: Jianxue Zhang, Lin Jiao, Yonggang Zhang