Patents by Inventor Lin Leng

Lin Leng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180105593
    Abstract: Methods and compositions for using the MEW class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: October 31, 2016
    Publication date: April 19, 2018
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Publication number: 20160152708
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: November 23, 2015
    Publication date: June 2, 2016
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Patent number: 9221903
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: December 29, 2015
    Assignees: Baxalta Incorporated, Baxalta GmbH
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Publication number: 20150010570
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: June 4, 2014
    Publication date: January 8, 2015
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Patent number: 8779099
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: July 15, 2014
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Publication number: 20140178403
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: November 26, 2013
    Publication date: June 26, 2014
    Applicants: Baxter Healthcare SA, Baxter International Inc.
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Patent number: 8617822
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: December 31, 2013
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Publication number: 20120039914
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: June 14, 2011
    Publication date: February 16, 2012
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Publication number: 20110020321
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: May 17, 2010
    Publication date: January 27, 2011
    Applicant: CYTOKINE PHARMASCIENCES, INC.
    Inventors: Richard J. BUCALA, Lin LENG, Christine N. METZ
  • Patent number: 7741057
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: June 22, 2010
    Assignee: Cytokine PharmaSciences, Inc.
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Publication number: 20100143379
    Abstract: The present invention relates to methods and compositions for selecting a subject for treatment with an agonist or antagonist of macrophage migration inhibitory factor (MIF), identifying a subject at risk for developing a disease associated with high or low MIF expression, predicting the severity of a disease associated with high or low MIF expression in a subject, and for predicting whether a subject is susceptible to a disease associated with high or low MIF expression. The invention also provides novel methods of diagnosing a patient for a disease associated with high or low MIF expression. Also provided are methods for treating a subject having a disease or disorder associated with high or low MIF expression.
    Type: Application
    Filed: April 26, 2006
    Publication date: June 10, 2010
    Inventors: Richard Bucala, Lin Leng, Sarah Doernberg
  • Publication number: 20090263404
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: April 4, 2008
    Publication date: October 22, 2009
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Publication number: 20090244836
    Abstract: A docking system which can be used with any laptop, and can allow a mouse or other peripheral device to attach to the back surface of the laptop screen, such as the top of the display when closed. A docking piece is attached to the flat surface of the laptop by means of an adhesive or other mechanism. The mouse or other accessory includes a docking element which engages the docking piece with a restraining force applied. A flat tool to remove the docking piece when it is no longer desired to be used.
    Type: Application
    Filed: March 31, 2008
    Publication date: October 1, 2009
    Inventors: Tung-Lin Leng, Padraig McLoughlin, Denis O'Keefe
  • Publication number: 20080146507
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 19, 2008
    Inventors: Richard J Bucala, Lin Leng, Christine N. Metz
  • Publication number: 20060024754
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: September 22, 2005
    Publication date: February 2, 2006
    Inventors: Richard Bucala, Lin Leng, Christine Metz
  • Publication number: 20030013122
    Abstract: Methods and compositions for using the MHC class II invariant chain polypeptide, Ii (also known as CD74), as a receptor for macrophage migration inhibitory factor (MIF), are disclosed. These include methods and compositions for using this receptor, as well as agonists and antagonists of MIF which bind to this receptor, or which otherwise modulate the interaction of MIF with CD74 or the consequences of such interaction, in treatment of conditions characterized by locally or systemically altered MIF levels, particularly inflammatory conditions and cancer.
    Type: Application
    Filed: March 29, 2002
    Publication date: January 16, 2003
    Inventors: Richard J. Bucala, Lin Leng, Christine N. Metz
  • Patent number: 5925541
    Abstract: The present invention relates to purified and isolated nucleic acid encoding the endo-.beta.-galactosidase from Flavobacterium keratolyticus (referred to as "ENDO-A"), and to purified ENDO-A protein. The endo-.beta.-galactosidase of the invention may be used in a process which enzymatically de-antigenizes human erythrocytes bearing A.sub.1 antigen. The resulting erythrocytes may be transfused into individuals who would be otherwise unable to tolerate a transfusion of type A.sub.1 blood.
    Type: Grant
    Filed: September 11, 1996
    Date of Patent: July 20, 1999
    Assignee: New York Blood Center, Inc.
    Inventors: Jack Goldstein, Alex Zhu, Lin Leng