Patents by Inventor Lin-Lin Shiao

Lin-Lin Shiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell fusion assays using fluorescence resonance energy transfer
    Patent number: 7029868
    Abstract: Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. The methods are suitable for identifying substances that are useful for the treatment and prevention of viral diseases. Particularly preferred methods are useful for the identification of inhibitors of HIV-1 infection.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: April 18, 2006
    Assignee: Merck & Co., Inc.
    Inventors: Kathleen A. Sullivan, Diana Benincasa, Margaret A. Cascieri, Lyndon J. Mitnaul, Lin-Lin Shiao, Michael R. Tota
  • Cell fusion assays using fluorescence resonance energy transfer
    Publication number: 20030036108
    Abstract: Methods of identifying inhibitors of the fusion of two types of cells, particularly when fusion is mediated by the interaction of a viral protein and such cellular proteins as CD4 and chemokine receptors, are disclosed. The methods are suitable for identifying substances that are useful for the treatment and prevention of viral diseases. Particularly preferred methods are useful for the identification of inhibitors of HIV-1 infection.
    Type: Application
    Filed: August 16, 2002
    Publication date: February 20, 2003
    Inventors: Kathleen A Sullivan, Diana Benincasa, Margaret A Cascieri, Lyndon J Mitnaul, Lin-Lin Shiao, Michael R Tota
  • Neuropeptide Y receptor
    Patent number: 5939263
    Abstract: A novel mammalian neuropeptide Y receptor and method of making the receptor are provided. The invention includes DNA encoding the receptor, the receptor, assays employing the receptor, cells expressing the receptor, antibodies which bind specifically to the receptor, RNA encoded by the DNA sequence or its complementary sequence, and single-stranded DNA with a sequence complementary to the RNA which encodes the receptor. The receptor and assays employing the receptor are useful for identifying compounds which bind to the receptor, including specific modulators of the receptor. Such compounds are useful for treating a variety of disease conditions, including obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, cardiac and cerebral vasospasm, pheochromocytoma and ganglioneuroblastoma, and Huntington's, Alzheimer's and Parkinson's diseases.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: August 17, 1999
    Assignee: Merck & Co., Ltd.
    Inventors: Margaret A. Cascieri, Douglas J. MacNeil, Lin-Lin Shiao, David H. Weinberg, Carina P. Tan, David L. Linemeyer, Catherine D. Strader
  • Neuropeptide Y receptor
    Patent number: 5621079
    Abstract: A novel mammalian neuropeptide Y receptor and method of making the receptor are provided. The invention includes DNA encoding the receptor, the receptor, assays employing the receptor, cells expressing the receptor, antibodies which bind specifically to the receptor, RNA encoded by the DNA sequence or its complementary sequence, and single-stranded DNA with a sequence complementary to the RNA which encodes the receptor. The receptor and assays employing the receptor are useful for identifying compounds which bind to the receptor, including specific modulators of the receptor. Such compounds are useful for treating a variety of disease conditions, including obesity, diabetes, anxiety, hypertension, cocaine withdrawal, congestive heart failure, memory enhancement, cardiac and cerebral vasospasm, pheochromocytoma and ganglioneuroblastoma, and Huntington's, Alzheimer's and Parkinson's diseases.
    Type: Grant
    Filed: April 3, 1995
    Date of Patent: April 15, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Margaret A. Cascieri, David L. Linemeyer, Douglas J. Macneil, Lin-Lin Shiao, Catherine D. Strader, David H. Weinberg, Carina P. Tan