Abstract: The present invention discloses an optical pulse design method for high-fidelity manipulation over ensemble qubits, so that fast and efficient two-color optical pulses that have high robustness against frequency detuning and a laser intensity fluctuation are constructed by using an inverse engineering method based on a Lewis-Riesenfeld invariant, and using a perturbation theory and a concept of a system error sensitivity. The pulses can be applied in an inhomogeneously broadened three-level system to create an arbitrary superposition state of ensemble qubits with a high fidelity. During action of the pulse, quantum manipulation has stronger robustness against instantaneous changes or spatial nonuniform distribution of a laser intensity. The robustness can increase a signal-to-noise ratio of a detected signal and reduce experimental difficulties.

Abstract: The present invention provides crystalline forms of (6S,7S)-6-fluoro-7-(2-fluoro-5-methylphenyl)-3-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (“Compound I”). Also provided are related pharmaceutical compositions, methods of preparation, and methods of treating hypertrophic cardiomyopathy (HCM), heart failure with preserved ejection fraction (HFpEF), diastolic dysfunction, left ventricular hypertrophy, and other cardiac diseases.

Abstract: Balloon catheter (22) having a coating comprises a primer layer (24) comprising at least one or more substantially hydrophilic compounds, a first layer (26) comprising an inclusion compound; and a second layer (28) comprising a mixture of a hydrophobic polymer, an active therapeutic agent and the inclusion compound.

Abstract: The present invention provides an energy-saving and heat-dissipating power line manufacturing method, and relates to the technical field of line manufacturing, and the specific solution is as follows: two feeding mechanisms are arranged on a feeding table in parallel, and one end of a power line wound on the feeding mechanisms penetrates through a cut-off mechanism through a feeding wheel and is fed into a terminal machine; the cut-off mechanism is started through a handle and cuts off the power line; the two feeding mechanisms are driven by a motor to rotate at the same time, and the winding directions of power lines on the two feeding mechanisms are the same. According to the auxiliary device, the problem that an existing line manufacturing terminal machine is low in working efficiency is solved, and synchronous feeding can be achieved by driving the two feeding bases through one motor.

Abstract: A signal sampling method comprising: sampling an electrical signal to be measured using a pre-determined sampling method to obtain a plurality of first sampling points, each of which is represented by a first amplitude and a corresponding first time; measuring a second amplitude of the electrical signal to be measured, wherein the second amplitude is different from the plurality of the first amplitudes; and delaying the electrical signal to be measured, and using the delayed electrical signal to determine a second time when the amplitude of the electrical signal to be measured reaches the second amplitude in order to obtain a second sampling point, which is represented by the second amplitude and the second time. A greater number of sampling points can be sampled, such that the precision of sampling and also the accuracy of subsequent signal restoration may be improved.

Abstract: The present invention discloses an optical pulse design method for high-fidelity manipulation over ensemble qubits, so that fast and efficient two-color optical pulses that have high robustness against frequency detuning and a laser intensity fluctuation are constructed by using an inverse engineering method based on a Lewis-Riesenfeld invariant, and using a perturbation theory and a concept of a system error sensitivity. The pulses can be applied in an inhomogeneously broadened three-level system to create an arbitrary superposition state of ensemble qubits with a high fidelity. During action of the pulse, quantum manipulation has stronger robustness against instantaneous changes or spatial nonuniform distribution of a laser intensity. The robustness can increase a signal-to-noise ratio of a detected signal and reduce experimental difficulties.

Abstract: The present invention discloses a tumor necrosis factor-related apoptosis-inducing ligand variant, which is a fusion protein of a tumor necrosis factor-related apoptosis-inducing ligand and an F3 peptide. The F3 peptide is fused to the N-terminus or C-terminus of the tumor necrosis factor-related apoptosis-inducing ligand by a linker. The present invention also discloses a nucleotide sequence, as well as a recombinant vector and a recombinant bacterium comprising same, and also discloses a preparation method and use of the foregoing variant.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.

Abstract: The present invention discloses a tumor necrosis factor-related apoptosis-inducing ligand variant, which is a fusion protein of a tumor necrosis factor-related apoptosis-inducing ligand and an F3 peptide. The F3 peptide is fused to the N-terminus or C-terminus of the tumor necrosis factor-related apoptosis-inducing ligand by a linker. The present invention also discloses a nucleotide sequence, as well as a recombinant vector and a recombinant bacterium comprising same, and also discloses a preparation method and use of the foregoing variant. The tumor necrosis factor-related apoptosis-inducing ligand variant is prepared by means of genetic engineering in the present invention, characterized in that its affinity for tumor cells, ability to induce apoptosis in tumor cells, tumor targeting property and in vivo anti-tumor effect are significantly better than those of the tumor necrosis factor-related apoptosis-inducing ligand.

Abstract: Embodiments may include a forecasting component that, for each of different service levels offered to customers, generates a projection of the quantity of shipments to be shipped according to that service level during a time period. The forecasting component may be configured to, based on an aggregate quantity of shipments projected to be shipped, modify the projected quantities of shipments for the multiple service levels. The forecasting component may, for each service level, receive information specifying a distribution of different shipment methods that are projected to be utilized to ship shipments of a particular priority designation to meet requirements of that service level. The forecasting component may, based on the distribution for each service level and the modified projected quantity of shipments for each service level, generate a forecast specifying quantities of shipments that are to be shipped during the time period according to each of the different shipment methods.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.

Abstract: The present invention discloses a conductive sensor and a urinal having conductive sensor. Said conductive sensor is installed in the sewer pipe of the urinal or toilet, which comprises an insulating body and a detecting electrode used for detecting the electric conductivity of the liquid in the sewer pipe. Said conductive sensor also comprises a self-cleaning device used for cleaning the end of the detecting electrode. Said self-cleaning device comprises a housing, a piston unit and a brush head unit. A water inlet pipe connected with the tap water pipe and a water outlet pipe connected with the sewer pipe are installed to said housing. Said brush head unit comprises a brush head used for cleaning the end of the detecting electrode. Thus, the detected result of conductive sensor and the urinal having conductive sensor are more reliable and the device is easy to be maintained.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.

Abstract: A pickup location that includes a control station and one or more storage compartment modules provides the ability for items to be ordered and delivered for pickup by a user without having to pack those items in a shipping package prior to shipping from a materials handling facility. Delivering items for pickup by a user without having to package the items prior to shipping, may provide a better experience for the customer, reduce waste in packaging material and a lower cost of delivering the ordered items to the customer.