Abstract: Disclosed in the present invention are a compound having a BRD4 inhibitory activity, a preparation method therefor and the use thereof. The structure of the compound having the BRD4 inhibitory activity of the present invention is as shown in formula I, and the definition of each substituent is as described in the description and claims. The compound of the present invention has a high bromodomain protein inhibitory activity, in particular a BRD4-targeting inhibitory activity, and can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: A SRE-PTPRZ1 inhibitor or a PTPRZ1 inhibitor in the preparation of a drug for treating squamous cell carcinoma are provided. The SRE-PTPRZl inhibitor is an inhibitor for SRE-PTPRZ1 structural variation, the SRE-PTPRZ1 structural variation being somatic simple repeat expansion at insertion site GRCh38 chr7: 121603263-121603506, the repeating pattern of an insertion region and a somatic cell simple repeat expansion sequence are (CTTT)n, in which 10?n<500. The PTPRZ1 inhibitor is one of the followings compounds, a pharmaceutically acceptable salt thereof, one or two derivatives among derivatives thereof, or a mixture of the above: NAZ2329, SCB4380, MY-33-3, or MY-10; and the HGNC number of the PTPRZ1 gene is 9685.

Abstract: A dry low NOX staged combustion system includes a fuel nozzle and a combustion compartment. The fuel nozzle includes a purge gas tube, a diffusion combustion fuel tube, an isolation gas tube, a premixed combustion fuel tube, a premixed combustion air tube. The purge gas tube is configured to feed a purge gas. The diffusion combustion fuel tube is fitted over the purge gas tube, and having an end provided with a diffusion combustion fuel swirler. The isolation gas tube is fitted over the diffusion combustion fuel tube. The premixed combustion fuel tube is fitted over the isolation gas tube. The premixed combustion air tube is fitted over the premixed combustion fuel tube. The combustion compartment is located downstream of the fuel nozzle.

Abstract: Disclosed is a nitrogen-containing heterocyclic compound, pharmaceutical compositions thereof and use thereof. The present disclosure provides a nitrogen-containing heterocyclic compound represented by formula I, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of pharmaceutically acceptable salt thereof, a crystal thereof, a stereoisomer thereof, a tautomer thereof or an isotopically labeled compound thereof. The nitrogen-containing heterocyclic compound represented by formula I is expected to treat and/or prevent various PI3K-meditated diseases.

Abstract: Disclosed in the present invention are a compound having a BRD4 inhibitory activity, a preparation method therefor and the use thereof. The structure of the compound having the BRD4 inhibitory activity of the present invention is as shown in formula I, and the definition of each substituent is as described in the description and claims. The compound of the present invention has a high bromodomain protein inhibitory activity, in particular a BRD4-targeting inhibitory activity, and can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: A button battery including a housing assembly, an electrode assembly, a first tab and a second tab. The housing assembly includes a first conductive portion and a second conductive portion insulated from each other. The electrode assembly includes first electrode plates and second electrode plates of opposite polarities. The first tab includes a first connecting portion and a first extension portion. The first connecting portion is connected to each first electrode plate, and the first extension portion assumes a continuously curved shape. One of the first conductive portion or the second conductive portion is connected to the first electrode plate. When the button battery is dropped, the electrode assembly inside the housing assembly is displaced relative to the housing assembly.

Abstract: A pulse detonation combustion system includes: an inlet pipe; an intake cone disposed in the inlet pipe, having an end provided with a pneumatic valve, and including an atomizing air transfer tube, a fuel transfer tube, and a conical swirl nozzle connected to the atomizing air transfer tube and the fuel transfer tube; an atomizing air intake tube connected with the atomizing air transfer tube; a fuel supply tube connected with the fuel transfer tube; a pulse detonation combustion chamber located downstream of and communicated to the inlet pipe, and provided with a spark plug mounting seat for mounting a spark plug; a gas energy distribution adjustment device located downstream of and communicated to the pulse detonation combustion chamber; and a transition section located downstream of and communicated to the gas energy distribution adjustment device.

Abstract: A gas turbine power generation device includes: an inlet pipe (1), a compressor (2), an air storage compartment (3), a compressor rotor (4), a compressor gear shift (6), a compressor exhaust pipeline (8), a combustion chamber intake pipeline (10), a combustion chamber intake cone (11), a combustion chamber pneumatic valve (14), a spark plug (19), a combustion chamber (21), a Tesla turbine (22), a gas collection compartment (27), an outlet pipe (28), a turbine rotor (30), a generator gear shift (32) and a generator (33).

Abstract: An electrode plate including an electrode plate body, a tab, a first adhesive layer, and a second adhesive layer. The tab includes a connecting portion connected to an extending portion. The connecting portion overlaps with and is connected to the electrode plate body. The extending portion protrudes from the connecting portion out of one side of the electrode plate body along a first direction. The first adhesive layer is disposed on the extending portion. The second adhesive layer includes a first part bonded to a surface of the electrode plate body and covering the connecting portion; and a second part formed by extending the first part from a side near the first adhesive layer along the first direction and bonded to the first adhesive layer. In a second direction perpendicular to the first direction, a width of the second part is less than a width of the first part.

Abstract: A gas turbine power generation device includes: an inlet pipe (1), a compressor (2), an air storage compartment (3), a compressor rotor (4), a compressor gear shift (6), a compressor exhaust pipeline (8), a combustion chamber intake pipeline (10), a combustion chamber intake cone (11), a combustion chamber pneumatic valve (14), a spark plug (19), a combustion chamber (21), a Tesla turbine (22), a gas collection compartment (27), an outlet pipe (28), a turbine rotor (30), a generator gear shift (32) and a generator (33).

Abstract: A pulse detonation combustion system includes: an inlet pipe; an intake cone disposed in the inlet pipe, having an end provided with a pneumatic valve, and including an atomizing air transfer tube, a fuel transfer tube, and a conical swirl nozzle connected to the atomizing air transfer tube and the fuel transfer tube; an atomizing air intake tube connected with the atomizing air transfer tube; a fuel supply tube connected with the fuel transfer tube; a pulse detonation combustion chamber located downstream of and communicated to the inlet pipe, and provided with a spark plug mounting seat for mounting a spark plug; a gas energy distribution adjustment device located downstream of and communicated to the pulse detonation combustion chamber; and a transition section located downstream of and communicated to the gas energy distribution adjustment device.

Abstract: A dry low NOX staged combustion system includes a fuel nozzle and a combustion compartment. The fuel nozzle includes a purge gas tube, a diffusion combustion fuel tube, an isolation gas tube, a premixed combustion fuel tube, a premixed combustion air tube. The purge gas tube is configured to feed a purge gas. The diffusion combustion fuel tube is fitted over the purge gas tube, and having an end provided with a diffusion combustion fuel swirler. The isolation gas tube is fitted over the diffusion combustion fuel tube. The premixed combustion fuel tube is fitted over the isolation gas tube. The premixed combustion air tube is fitted over the premixed combustion fuel tube. The combustion compartment is located downstream of the fuel nozzle.

Abstract: The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical composition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Abstract: Embodiments provide methods and systems for modeling the flow of fluid in variable physical and geological environments using dynamically determined Navier-Stokes equations (NSE), such as Darcy Flow and Poiseuille flow.

Abstract: A split-screen display method and apparatus, and an electronic device thereof. A horizontal slide signal along a touchscreen or a vertical slide signal along the touchscreen entered by using the touchscreen is obtained; a current display area of the touchscreen is divided, according to the horizontal slide signal, into at least two display windows arranged up and down, or a current display area of the touchscreen is divided, according to the vertical slide signal, into at least two display windows arranged side by side, thereby implementing that multiple application programs are simultaneously displayed on a screen up and down or side by side, and a user does not need to frequently switch between programs, which facilitates user operations.

Abstract: A method and system for evaluating fitness between a wearer and eyeglasses worn by the wearer, the method comprising steps of: generating facial attribute data associated with the wearer; generating attribute data of the eyeglasses; establishing wearer model based on the facial attribute data; establishing eyeglasses model based on the eyeglasses attribute data; comparing the wearer model and the eyeglasses model and evaluating the fitness there between; and generating a rating score information indicative of to which extent the eyeglasses improves the wearer visage based on the fitness evaluation result. By means of this method, the wearer of the eyeglasses can easily learn the matching/fitness degree of the eyeglasses worn by the wearer with his or her face, so as to help the wearer to decide whether or not to purchase or use the eyeglasses.

Abstract: A computer-implemented method includes defining respective positions of a first set of nodes and a second set of nodes in an enrichment region, and performing a coupled pore fluid diffusion and stress analysis on the enrichment region at the first set of nodes. It is then determined whether the second set of nodes is activated—representing a fracture—as a result of the analysis, and the results are visually output to a user.

Abstract: Embodiments provide methods and systems for modeling the flow of fluid in variable physical and geological environments using dynamically determined Navier-Stokes equations (NSE), such as Darcy Flow and Poiseuille flow.

Abstract: A split-screen display method and apparatus, and an electronic device thereof. A horizontal slide signal along a touchscreen or a vertical slide signal along the touchscreen entered by using the touchscreen is obtained; a current display area of the touchscreen is divided, according to the horizontal slide signal, into at least two display windows arranged up and down, or a current display area of the touchscreen is divided, according to the vertical slide signal, into at least two display windows arranged side by side, thereby implementing that multiple application programs are simultaneously displayed on a screen up and down or side by side, and a user does not need to frequently switch between programs, which facilitates user operations.

Abstract: Embodiments of the present invention disclose a method, an apparatus, and a system for a layer 2 interworking based on an IPv6. The method includes: receiving a router solicitation packet of the first terminal device, and sending a router advertisement packet to the first terminal device. The router advertisement packet carries a prefix option including an AdvOnlink tag and a management tag, to enable generation of a direct route to the second terminal device according to the AdvOnlink tag, and the management tag is used to direct the first terminal device to adopt a DHCP to obtain an IP address. The method, apparatus, and system provided according to embodiments of the present invention may implement the direct route between terminal devices to which IPv6 addresses with a same prefix are assigned by a same DHCP server.