Abstract: A connection method includes obtaining first communication identification information stored in a local storage region of a remote controller, matching second communication identification information broadcasted by an electrical appliance with the first communication identification information, and establishing, in response to the second communication identification information being successfully matched with the first communication identification information, a short-range radio-frequency communication link between the remote controller and the electrical appliance. The short-range radio-frequency communication link being used for control of the electrical appliance by the remote controller.

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

Abstract: Disclosed are p53 peptidomimetic macrocycles, each p53 peptidomimetic macrocycle comprising an i, i+4 olefin staple and a polypeptide tail covalently linked to the p53 peptidomimetic macrocycle; an i, i+7 olefin staple and a polypeptide tail covalently linked to the p53 peptidomimetic macrocycle; or, an i, i+7 di-alkyne staple and optionally a polypeptide tail covalently linked to the p53 peptidomimetic macrocycle; wherein the p53 peptidomimetic macrocycle comprises all D-configuration amino acids and the polypeptide tail comprises three to nine amino acids, each amino acid of the polypeptide tail independently having a D-configuration or an L-configuration. The p53 peptidomimetic macrocycles are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX, thereby antagonizing MDM2 and MDMX binding to p53.

Abstract: The crosslinked peptidomimetic macrocycles disclosed herein comprise an alkene or alkyne staple and a poly-amino acid C-terminal tail. These crosslinked peptidomimetic macrocycles have improved binding to MDM2 and MDMX (aka MDM4), are protease resistant, cell permeable without inducing membrane disruption, and intracellularly activate p53 by binding MDM2 and MDMX thereby antagonizing MDM2 and MDMX binding to p53. These peptidomimetic macrocycles may be useful in anticancer therapies, particularly in combination with chemotherapy or radiation therapy.

Abstract: The present disclosure provides a storage control method, including: sending a command acquisition request for at least one first queue, where the at least one first queue is a queue among a plurality of queues which accumulates at least one queue request message, and a command acquisition request for each first queue of the at least one first queue corresponds to all accumulated queue request messages of the first queue; and receiving a storage command for each first queue in the at least one first queue.

Abstract: An operation control method for a household electrical appliance includes performing network configuration with a plurality of servers according to different network protocols; upon receiving a control instruction sent by one of the plurality of servers, determining a processing priority of the control instruction; and processing the control instruction according to the processing priority and a preset multi-protocol processing mechanism.

Abstract: A networking method for a household appliance, a household appliance, and a terminal device are provided. The household appliance is provided with a network module. According to the method, the network module receives router information and the account and the password of a router transmitted by a mobile terminal. The router information contains time-related data required for logging into the router; according to the router information and the account and the password of the router, log into the router.

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

Abstract: The present disclosure provides conjugates that comprise an insulin molecule conjugated via a conjugate framework to two or more separate ligands that each include a saccharide, wherein the framework, ligand, saccharide and insulin molecule optionally comprise a fatty chain (e.g., a C8-30 fatty chain), wherein when said insulin molecule is conjugated both to a C8-30 fatty chain and one or more separate ligands that each include a saccharide, said C8-30 fatty chain is linked to insulin molecule only, and wherein when the framework or ligand comprises a fatty chain the insulin molecule is conjugated to two or more separate ligands. In certain embodiments, a conjugate is characterized in that, when the conjugate is administered to a mammal, at least one pharmacokinetic (PK) and/or pharmacodynamic (PD) property of the conjugate is sensitive to serum concentration of a second saccharide. In certain embodiments, a conjugate is also characterized by having a protracted PK profile.

Abstract: The present invention relates to insulin analogues and processes of making such insulin analogues by direct conversion of a free amine to an azide via diazo-transfer with an azotransfer agent.

Abstract: Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

Abstract: An approach is disclosed that determines an amount of time before a webpage is ready to use by a user by performing various actions. The approach captures a recording of the webpage from an invocation of the webpage for a period of time sufficient to load completely load the webpage with the capturing resulting in sequenced image frames. An AI system provides a loading point in the sequenced image frames based on an analysis of the frames input to the trained AI system. Image diversity and saturation measurements are calculated on consecutive image frames from the sequenced image frames resulting in an image change analysis. Native webpage events and times are detected from webpage characteristics gathered from the captured digital recording. The amount of time is then calculated based on the loading point from the AI system, the image change analysis; and the webpage events and their corresponding times.

Abstract: A household appliance network configuration method includes controlling a household appliance to start a network configuration mode and a network monitoring mode, establishing a monitoring link between the household appliance and a client based on the network monitoring mode, receiving network configuration information of the client, performing a network configuration connection for the household appliance based on the network configuration information and the network configuration mode, monitoring a process of performing the network configuration connection to obtain network configuration monitoring information, and transmitting the network configuration monitoring information to the client through the monitoring link.

Abstract: Aspects of the present disclosure relate to input text management. Input text can be received from a user. A set of key elements can be extracted from the input text. A determination can be made whether the user is mapped to an existing cluster. In response to determining that the user is mapped to an existing cluster, a structured table mapping key elements to text modifications can be referenced. The input text can be modified according to the structured table mapping key elements to text modifications, wherein the existing cluster is associated with a text modification scheme within the structured table, wherein the text modification scheme includes a first mapping of key elements to text modifications.

Abstract: Insulin-incretin conjugates comprising a peptide having agonist activity at the glucagon-like 1 (GLP-1) receptor, the glucagon (GCG) receptor, and/or the gastric inhibitory protein (GIP) receptor conjugated to an insulin molecule having agonist activity at the insulin receptor and use of the conjugates for treatment of metabolic diseases, for example, Type 2 diabetes, are described.

Abstract: An approach is disclosed that determines an amount of time before a webpage is ready to use by a user by performing various actions. The approach captures a recording of the webpage from an invocation of the webpage for a period of time sufficient to load completely load the webpage with the capturing resulting in sequenced image frames. An AI system provides a loading point in the sequenced image frames based on an analysis of the frames input to the trained AI system. Image diversity and saturation measurements are calculated on consecutive image frames from the sequenced image frames resulting in an image change analysis. Native webpage events and times are detected from webpage characteristics gathered from the captured digital recording. The amount of time is then calculated based on the loading point from the AI system, the image change analysis; and the webpage events and their corresponding times.

Abstract: An operation control method for a household electrical appliance includes performing network configuration with a plurality of servers according to different network protocols; upon receiving a control instruction sent by one of the plurality of servers, determining a processing priority of the control instruction; and processing the control instruction according to the processing priority and a preset multi-protocol processing mechanism.

Abstract: Aspects of the present disclosure relate to input text management. Input text can be received from a user. A set of key elements can be extracted from the input text. A determination can be made whether the user is mapped to an existing cluster. In response to determining that the user is mapped to an existing cluster, a structured table mapping key elements to text modifications can be referenced. The input text can be modified according to the structured table mapping key elements to text modifications, wherein the existing cluster is associated with a text modification scheme within the structured table, wherein the text modification scheme includes a first mapping of key elements to text modifications.

Abstract: Glucose-responsive insulin conjugates that contain one or more trisaccharides are provided. Such insulin conjugates may display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose, even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule.

Abstract: A system for integrating wireless service providers' core networks with Wi-Fi radios using a Wireless Services Gateway (WSG). The WSG can allow wireless device users to seamlessly connect to a network such as the internet using both cellular phone antennae as well as Wi-Fi radio antennae while still utilizing their preferred wireless service provider's core network system of billing, authenticating and policy decision making. This system can allow for data transmission of wireless devices through Wi-Fi instead of through cellular antennae, thus increasing bandwidth and data transmission rates.