Abstract: A fabric light transmittance testing device comprises a supporting frame, a middle portion of an inner side of which is fixedly connected with a platform plate, a top surface of the supporting frame is fixedly connected with a top fixing plate having a top surface fixedly connected with a hydraulic rod, a bottom surface of the platform plate is fixedly connected with a light transmission testing mechanism, a cloth fastening mechanism is arranged above the light transmission testing mechanism, one side of the top fixing plate is provided with an unwinding control mechanism, four vertical sliding rods slidably penetrate through an upper surface of the top fixing plate, a bottom surface of the vertical sliding rod is fixedly connected with a detection bottom plate, a top surface of the platform plate is fixedly connected with a slope plate, and the light transmission testing mechanism comprises a side fixing plate.

Abstract: An outer surface polishing device for a pull-resistance type sensor comprises a mounting support for mounting polishing and grinding equipment, the mounting support comprises second shells fixedly mounted on a left side and a right side of a first shell and hydraulic arms mounted on an upper surface of the two second shells. The polishing and grinding equipment consists of a polishing wheel, a grinding and cleaning wheel and a driving motor; water conveying equipment is mounted on the first shell and comprises a gearbox fixedly mounted outside the first shell, a separation net detachably mounted in the first shell, a transmission gear and a driven gear rotationally arranged in the gearbox, and two communicating pipes fixedly communicated with opposite sides of the gearbox.

Abstract: The present disclosure provides for mouth rescue rinse, methods of using the mouth rescue rinse, and methods of regulating (e.g., maintaining or reducing) blood pressure in a subject.

Abstract: In this vein, we present CTLAP, a fluorogenic probe that is rapidly activated by CTL and displays good selectivity over CTB and CTV, the closest competing analytes for CTL activity probes. CTLAP exhibits intrinsically low background fluorescence, which we attribute to the notably low quantum yield measured for the probe. CTLAP demonstrates markedly higher turn-on ratios (24-fold) and moderately improved enzyme selectivity (6- to 10-fold) when compared to Z-FR-AMC (10-fold turn-on ratio, 6- to 7-fold selectivity), a commercially available CTL-selective probe commonly used to detect CTL activity in mixed samples. Optimum selectivity for CTL is achieved within 10 min of incubation with the enzyme, suggesting that CTLAP is amenable for rapid detection of CTL, even in the presence of competing cathepsins.

Abstract: Disclosed are imaging probes for detecting senescent cells based on quinone methide chemistry for different in vivo imaging modalities including near-infrared (NIR), positron emission tomography (PET) and magnetic resonance (MR) imaging and the methods of use thereof.

Abstract: A probe comprising a biomarker-triggered moiety, a near infrared (NIR) fluorophore reporter, a self-immolative linker and a self-immobilizing moiety for visualization of senescent cells and methods of use thereof.

Abstract: In this vein, we present CTLAP, a fluorogenic probe that is rapidly activated by CTL and displays good selectivity over CTB and CTV, the closest competing analytes for CTL activity probes. CTLAP exhibits intrinsically low background fluorescence, which we attribute to the notably low quantum yield measured for the probe. CTLAP demonstrates markedly higher turn-on ratios (24-fold) and moderately improved enzyme selectivity (6- to 10-fold) when compared to Z-FR-AMC (10-fold turn-on ratio, 6- to 7-fold selectivity), a commercially available CTL-selective probe commonly used to detect CTL activity in mixed samples. Optimum selectivity for CTL is achieved within 10 min of incubation with the enzyme, suggesting that CTLAP is amenable for rapid detection of CTL, even in the presence of competing cathepsins.

Abstract: The invention relates to compounds that interact with heparanase, uses in heparanase screening, uses in in vitro and in vivo imaging (e g , positron emission tomography (PET) and magnetic resonance imaging (MRI)), methods of synthesis, methods of modulating heparanase activity, and methods of treating disease and disorders associated with heparanase. The compounds of the invention are also useful in treating one or more diseases or disorders associated with the function of heparanase.

Abstract: Provided are embodiments of a small molecule tracer for positron emission tomography (PET) imaging of the enzyme activity of PARP-1 that is responsible for DNA-damage sensing and critically involved in radiation therapy and some chemotherapy response mechanisms. These PARP-1 tracers are derivatives of nicotinamide adenine dinucleotide (NAD), which is the natural substrate for PARP-1. Provided are NAD derivatives that include a linker moiety to which may be attached a label moiety such as a PET detectable fluorine to generate a 6N-(triazo-PEG2-18F)-NAD. Especially advantageous for use in PET and MRI scanning detection systems is the attachment of a chelating agent that allows for the formation of a chelator-metal ion complex.

Abstract: The present application provides an amphiphilic cyclodextrin-based compound of the formula I: R-G-D-A (I) wherein R is one or more hydrophilic groups; G is one or more linkers; D is a cyclodextrin, and A is one or more aliphatic groups. In cer-tain embodiments, the hydrophilic group is a sugar such as lactose, the linker comprises —(CHR?CH20)n- where R? is H or is an alkyl group substituted with —(CHR?CH20)n- where n is 1 to 20, typically n=4; the cyclodextrin is a B-cyclodextrin comprising 7 subunits, and the aliphatic groups are C6 alkyl groups. The compound can be used to enhance water solu-bility, bioavailability, cellular uptakes of active ingredients used in medicines, cosmetics and foods and other products, for detection, removal and immobilization of pathogenic organisms, toxins, and autoantibodies, and bio-markers on solid matrix, or for molecular biological techniques, such as ELISA, for example.

Abstract: The present application provides an amphiphilic cyclodextrin-based compound of the formula I: R-G-D-A (I) wherein R is one or more hydrophilic groups; G is one or more linkers; D is a cyclodextrin, and A is one or more aliphatic groups. In certain embodiments, the hydrophilic group is a sugar such as lactose, the linker comprises —(CHR?CH2O)n— where R? is H or is an alkyl group substituted with —(CHR?CH2O)n— where n is 1 to 20, typically n=4; the cyclodextrin is a ?-cyclodextrin comprising 7 subunits, and the aliphatic groups are C6 alkyl groups. The compound can be used to enhance water solubility, bioavailability, cellular uptakes of active ingredients used in medicines, cosmetics and foods and other products, for detection, removal and immobilization of pathogenic organisms, toxins, and autoantibodies, and biomarkers on solid matrix, or for molecular biological techniques, such as ELISA, for example.

Abstract: The present application provides an amphiphilic cyclodextrin-based compound of the formula I: R-G-D-A (I) wherein R is one or more hydrophilic groups; G is one or more linkers; D is a cyclodextrin, and A is one or more aliphatic groups. In certain embodiments, the hydrophilic group is a sugar such as lactose, the linker comprises —(CHR?CH2O)n— where R? is H or is an alkyl group substituted with —(CHR?CH2O)n— where n is 1 to 20, typically n=4; the cyclodextrin is a ?-cyclodextrin comprising 7 subunits, and the aliphatic groups are C6 alkyl groups. The compound can be used to enhance water solubility, bioavailability, cellular uptakes of active ingredients used in medicines, cosmetics and foods and other products, for detection, removal and immobilization of pathogenic organisms, toxins, and autoantibodies, and biomarkers on solid matrix, or for molecular biological techniques, such as ELISA, for example.

Abstract: Provided are embodiments of a small molecule tracer for positron emission tomography (PET) imaging of the enzyme activity of PARP-1 that is responsible for DNA-damage sensing and critically involved in radiation therapy and some chemotherapy response mechanisms. These PARP-1 tracers are derivatives of nicotinamide adenine dinucleotide (NAD), which is the natural substrate for PARP-1. Provided are NAD derivatives that include a linker moiety to which may be attached a label moiety such as a PET detectable fluorine to generate a 6N-(triazo-PEG2-18F)-NAD. Especially advantageous for use in PET and MRI scanning detection systems is the attachment of a chelating agent that allows for the formation of a chelator-metal ion complex.