Patents by Inventor Lina Li
Lina Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170334818Abstract: Disclosed is a method for preparing a double end capped glycol ether, the method comprising: introducing into a reactor a raw material comprising a glycol monoether and a monohydric alcohol ether, and enabling the raw material to contact and react with an acidic molecular sieve catalyst to generate a double end capped glycol ether, a reaction temperature being 50-300° C., a reaction pressure being 0.1-15 MPa, a WHSV of the glycol monoether in the raw material being 0.01-15.0 h?1, and a mole ratio of the monohydric alcohol ether to the glycol monoether in the raw material being 1-100:1. The method of the present invention enables a long single-pass lifespan of the catalyst and repeated regeneration, has a high yield and selectivity of a target product, low energy consumption during separation of the product, a high economic value of a by-product, and is flexible in production scale and application.Type: ApplicationFiled: December 22, 2014Publication date: November 23, 2017Applicant: Dalian Institute of Chemical Physics, Chinese Academy of SciencesInventors: Youming NI, Wenliang ZHU, Hongchao LIU, Yong LIU, Zhongmin LIU, Lina LI, Shiping LIU, Hui Zhou
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Publication number: 20170320808Abstract: A method for preparing methyl formate in which a raw material containing formaldehyde, methanol and/or dimethyl ether is introduced into a first reaction zone to come into contact with a catalyst A, and a component I is obtained by separation, the component I is introduced into a second reaction zone to come into contact with a catalyst B so as to obtain, by separation, methyl formate as a product, dimethyl ether that is returned to the first reaction zone and a component II that is returned to the second reaction zone, the catalysts have a long service life, the reaction conditions are mild, and the utilization rate of the raw material is high, thus enabling a continuous production for large-scale industrial application.Type: ApplicationFiled: November 17, 2014Publication date: November 9, 2017Applicant: Dalian Institute of Chemical Physics, Chinese Academy of SciencesInventors: Youming NI, Wenliang ZHU, Yong LIU, Hongchao LIU, Zhongmin LIU, Lina LI, Shiping LIU, Hui ZHOU
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Publication number: 20170320807Abstract: Method for preparing methyl formate and coproducing dimethyl ether by reacting a formaldehyde and methanol raw material (molar ratio range of 1:4 to 1:0.05) in a First Reaction Region at ranges from 50° C. to 100° C. with Catalyst A resulting in post-reaction material separated into Constituent I. Reacting Constituent I in a Second Reaction Region at ranges from 50° C. to 200° C. and from 0.1 MPa to 10 MPa with Catalyst B resulting in post-reaction material, which is separated into methyl formate, dimethyl ether and Constituent II. At least 1% of dimethyl ether is product, and recycling the rest to the First Reaction Region. Constituent II is recycled to the Second Reaction Region. Each component is gaseous phase and/or liquid phase, independently. The method shows long catalyst life, mild reaction condition, high utilization ratio of raw materials, continuous production and large scale industrial application potential.Type: ApplicationFiled: November 17, 2014Publication date: November 9, 2017Applicant: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Youming NI, Wenliang ZHU, Yong LIU, Hongchao LIU, Zhongmin LIU, Lina LI, Shiping LIU, Hui ZHOU
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Patent number: 9708240Abstract: A method for preparing a polyoxymethylene dimethyl ether carbonyl compound and/or methyl methoxyacetate as intermediates for producing ethylene glycol, which comprises passing a raw material: polyoxymethylene dimethyl ether or methylal together with carbon monoxide and hydrogen gas through a reactor carrying an acidic molecular sieve catalyst, and performing a reaction to prepare a corresponding product under an appropriate condition where no other solvent is added, in which the process of the reaction is a gas-liquid-solid three-phase reaction, the raw material of polyoxymethylene dimethyl ether or methylal has a high conversion rate, each product has a high selectivity, the catalyst has a long service life, additional solvents are not required to be used, and reaction conditions are relatively mild.Type: GrantFiled: December 23, 2013Date of Patent: July 18, 2017Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Youming Ni, Wenliang Zhu, Hongchao Liu, Yong Liu, Zhongmin Liu, Shuanghe Meng, Lina Li, Shiping Liu, Hui Zhou
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Patent number: 9598703Abstract: An isolated linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest and a second AAV ITR, wherein said nucleic acid molecule is devoid of AAV capsid protein coding sequences. The said nucleic acid molecule can be applied to a host at repetition without eliciting an immune response. Methods for producing and purifying this nucleic acid molecule, and use of the same for therapeutic purposes are also provided.Type: GrantFiled: March 12, 2012Date of Patent: March 21, 2017Assignees: ASSOCIATION INSTITUT DE MYOLOGIE; UNIVERSITÉ PIERRE ET MARIE CURIE (PARIS 6); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; INSTITUT NATIONAL DE LA SANTÉ DE LAD RECHERCHE MÉDICALE, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTHInventors: Luis Garcia, Cyriaque Beley, Thomas Voit, Robert Michael Kotin, Lina Li
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Publication number: 20170001941Abstract: A method for preparing a polyoxymethylene dimethyl ether carbonyl compound and/or methyl methoxyacetate as intermediates for producing ethylene glycol, which comprises passing a raw material: polyoxymethylene dimethyl ether or methylal together with carbon monoxide and hydrogen gas through a reactor carrying an acidic molecular sieve catalyst, and performing a reaction to prepare a corresponding product under an appropriate condition where no other solvent is added, in which the process of the reaction is a gas-liquid-solid three-phase reaction, the raw material of polyoxymethylene dimethyl ether or methylal has a high conversion rate, each product has a high selectivity, the catalyst has a long service life, additional solvents are not required to be used, and reaction conditions are relatively mild.Type: ApplicationFiled: December 23, 2013Publication date: January 5, 2017Inventors: Youming NI, Wenliang ZHU, Hongchao LIU, Yong LIU, Zhongmin LIU, Shuanghe MENG, Lina LI, Shiping LIU, HUI ZHOU
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Publication number: 20160311740Abstract: A method for producing ethanol and coproducing methanol on a catalyst in a reactor using a co-feed of a synthesis gas and acetate as a reaction raw material comprising passing a raw material gas containing an acetate and a synthesis gas through a reactor loaded with a catalyst to produce ethanol and coproduce methanol under conditions of a reaction temperature of 150-350° C., a reaction pressure of 0.1-20.0 MPa, a reaction volume hourly space velocity of 100-45000 mlg?1h?1, and an acetate weight hourly space velocity of 0.01-5.0 h?1; and the active components of the catalyst are copper and optionally zinc and/or aluminum, which greatly facilitates the conversion of carbon monoxide to methanol, while an extremely high activity of acetate hydrogenation is maintained.Type: ApplicationFiled: December 16, 2013Publication date: October 27, 2016Inventors: Yong LIU, Wenliang ZHU, Hongchao LIU, Youming NI, Zhongmin LIU, Shuanghe MENG, Lina LI, Shiping LIU, HUI ZHOU
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Patent number: 9440226Abstract: The present invention provides a method for preparing methyl acetate, in which a feed gas containing an organic amine, dimethyl ether, carbon monoxide and optional hydrogen gas goes through a reactor loaded with a H-type mordenite catalyst, to produce methyl acetate; wherein said H-type mordenite catalyst is a H-type mordenite catalyst with adsorption of an organic amine. The method in the present invention improves the catalyst stability and prolongs the catalyst life, by using the H-type mordenite catalyst with adsorption of an organic amine as the catalyst and adding the organic amine in the feed gas to replenish the organic amine desorbed from the catalyst during the reaction.Type: GrantFiled: January 28, 2014Date of Patent: September 13, 2016Assignee: DALIAN INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCESInventors: Youming Ni, Wenliang Zhu, Hongchao Liu, Yong Liu, Zhongmin Liu, Shuanghe Meng, Lina Li, Shiping Liu, Hui Zhou
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Publication number: 20150298108Abstract: The present invention provides a method for preparing methyl acetate, in which a feed gas containing an organic amine, dimethyl ether, carbon monoxide and optional hydrogen gas goes through a reactor loaded with a H-type mordenite catalyst, to produce methyl acetate; wherein said H-type mordenite catalyst is a H-type mordenite catalyst with adsorption of an organic amine. The method in the present invention improves the catalyst stability and prolongs the catalyst life, by using the H-type mordenite catalyst with adsorption of an organic amine as the catalyst and adding the organic amine in the feed gas to replenish the organic amine desorbed from the catalyst during the reaction.Type: ApplicationFiled: January 28, 2014Publication date: October 22, 2015Applicant: Dalian Institute of Chemical Physics, Chinese Academy of SciencesInventors: Youming NI, Wenliang ZHU, Hongchao LIU, Yong LIU, Zhongmin LIU, Shuanghe MENG, Lina LI, Shiping LIU, Hui ZHOU
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Patent number: 7723044Abstract: This invention generally relates to apparatus and methods for high-throughput, reproducible and inexpensive detection of virus infection using multiplexing technologies such as slide-based, microtiter plate-based and membrane-based microarrays and beads technologies. The apparatus and methods allow simultaneous detection of multiple viral infections in a plurality of test samples.Type: GrantFiled: April 12, 2005Date of Patent: May 25, 2010Assignee: Allied Biotech, Inc.Inventors: Yongyi Yu, Lina Li, Zhuangwu Li, Jun Bao
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Publication number: 20100093051Abstract: A process for regulating transcriptional activity of a gene is provided. The process comprises introducing genetic material into an organism, placing a gene downstream of a light-regulated promoter within the organism having a light responsive element and subjecting the organism to an exogenous light source. The genetic material is selected from a photosynthetic bacterium and the light source is configured to control the level of transcriptional activity of the gene.Type: ApplicationFiled: October 26, 2007Publication date: April 15, 2010Inventors: David M. Kehoe, Lina Li, Richard M. Alvey
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Patent number: 7390621Abstract: A method for determining telomerase activity using primer extension followed with real time PCR quantification is disclosed. The method of the present invention provides a rapid, sensitive and accurate measurement for telomerase activity in a biological sample. In one embodiment, the method includes the steps of: adding the biological sample to a reaction tube containing a first reaction mixture having a first primer and nucleoside triphosphates, a second reaction mixture having a second primer and a DNA polymerase, and a wax layer that separates the first reaction mixture from the second reaction mixture; incubating the biological sample with the first reaction mixture; admixing the extension product with the second reaction mixture; amplifying and quantifying the extension product using real-time PCR and a control template. In another embodiment, the detection method includes an in situ primer extension step that allows the production of the extension product within an intact cell.Type: GrantFiled: November 12, 2003Date of Patent: June 24, 2008Assignee: Allied Biotech, Inc.Inventors: Zhunagwu Li, Jun Bao, Hua Mao, Wenbin Ma, Lina Li
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Publication number: 20070212682Abstract: This invention generally relates to apparatus and methods for high-throughput, reproducible and inexpensive detection of virus infection using multiplexing technologies such as slide-based, microtiter plate-based and membrane-based microarrays and beads technologies. The apparatus and methods allow simultaneous detection of multiple viral infections in a plurality of test samples.Type: ApplicationFiled: April 12, 2005Publication date: September 13, 2007Inventors: Yongyi Yu, Lina Li, Zhuangwu Li, Jun Bao
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Publication number: 20060246441Abstract: A method for determining telomerase activity using primer extension followed with real time PCR quantification is disclosed. The method of the present invention provides a rapid, sensitive and accurate measurement for telomerase activity in a biological sample. In one embodiment, the method includes the steps of: adding the biological sample to a reaction tube containing a first reaction mixture having a first primer and nucleoside triphosphates, a second reaction mixture having a second primer and a DNA polymerase, and a wax layer that separates the first reaction mixture from the second reaction mixture; incubating the biological sample with the first reaction mixture; admixing the extension product with the second reaction mixture; amplifying and quantifying the extension product using real-time PCR and a control template. In another embodiment, the detection method includes an in situ primer extension step that allows the production of the extension product within an intact cell.Type: ApplicationFiled: November 12, 2003Publication date: November 2, 2006Applicant: Allied Biotech, Inc.Inventors: Li Zhuangwu, Bao Jun, Ma Wenbin, Lina Li