Abstract: Described here is are antibodies to CCR8 having enhanced binding, ligand blocking and antibody dependent cellular cytotoxicity. Also described is are methods of treating a cancer by targeting tumor infiltrating lymphocytes in a cancer patient using a formulation comprising a CCR8 antibody described above.

Abstract: A starting signal providing module, a starting signal providing method and a splicing display device are provided. The starting signal providing module comprises a detection circuit, a plurality of signal generating circuits and a plurality of enabling circuits. The signal generating circuit is configured to generate and provide a feedback signal to the detecting circuit when a last-stage scan driving signal output terminal of a scan driving circuit in a corresponding display panel outputs a valid scan driving signal. The detection circuit is configured to provide an enabling control signal to enabling circuits corresponding to at least two signal generating circuits according to the feedback signals from at least two signal generating circuits. The enabling circuit is configured to control a starting signal to be supplied to a scan driving circuit included in a corresponding display panel upon receiving the enabling control signal.

Abstract: The present application relates to the technical field of material processing, and especially relates to a method for preparing a magnesium alloy bone screw bar via room-temperature rotary forging under alternating magnetic field in conjunction with cryogenic processing and a magnesium alloy bone screw product.

Abstract: A starting signal providing module, a starting signal providing method and a splicing display device are provided. The starting signal providing module comprises a detection circuit, a plurality of signal generating circuits and a plurality of enabling circuits. The signal generating circuit is configured to generate and provide a feedback signal to the detecting circuit when a last-stage scan driving signal output terminal of a scan driving circuit in a corresponding display panel outputs a valid scan driving signal. The detection circuit is configured to provide an enabling control signal to enabling circuits corresponding to at least two signal generating circuits according to the feedback signals from at least two signal generating circuits. The enabling circuit is configured to control a starting signal to be supplied to a scan driving circuit included in a corresponding display panel upon receiving the enabling control signal.

Abstract: The present application relates to the technical field of material processing, and especially relates to a method for preparing a magnesium alloy bone screw bar via room-temperature rotary forging under alternating magnetic field in conjunction with cryogenic processing and a magnesium alloy bone screw product.

Abstract: A display substrate and a touch-control display device are disclosed. The display substrate comprises pixel units arranged in an array on a base substrate, signal lines, and a grid-shaped cathode layer; a sub-pixel in the pixel unit comprises a pixel opening area; the cathode layer comprises first cathode patterns and a second cathode patterns, the first cathode patterns are arranged in an array, and adjacent first cathode patterns are coupled via at least one second cathode pattern; an orthographic projection of the first cathode pattern onto the base substrate covers each pixel opening area in a corresponding pixel unit; an orthographic projection of the second cathode pattern onto the base substrate at least partially overlaps with an orthographic projection of at least part of the signal lines onto the base substrate.

Abstract: The present disclosure provides an electromagnetic shielding film, a flexible circuit board and a display device. The electromagnetic shielding film includes a central portion and an edge portion. The central portion has a plurality of surrounding side edges; and the edge portion is provided on at least one side edge of the central portion, and includes a plurality of protruding units protruding away from the central portion. The plurality of protruding units are arranged in an extending direction of the side edge where the edge portion is located. The electromagnetic shielding film is used to attach on a flexible circuit board body, the central portion is located on a non-bending area, and the edge portion is located on a bending area, so that the flexible circuit board is formed.

Abstract: The present disclosure provides a flexible display screen and a display device. The flexible display screen includes: a substrate; a backing film stacked on a side of the substrate facing away from a light-emitting surface of the flexible display screen; and a pressure sensor stacked on a side of the backing film facing away from the substrate and configured to output a signal related to a force applied on the flexible display screen.

Abstract: A method for preparing 1,3-diacylglycerol by immobilizing Sn-2 lipase. The present application obtains the Sn-2 lipase adsorbed by the macroporous resin by adsorbing the Sn-2 lipase on the resin, cross-links and immobilizes the Sn-2 lipase, and obtains 1,3-diglycerol by one-step hydrolysis with the lipase. The method improves the utilization times, hydrolysis activity and specificity of the Sn-2 lipase during hydrolysis, and determines the optimal parameters by improving the experimental conditions. This makes up for the shortcomings of immobilization and realizes the one-step hydrolysis of 1,3-diacylglycerol. Under optimal conditions, the hydrolase activity of immobilized lipase CAL-A is 1937.86U/g, and the immobilization rate can reach 94.49%, and has good operational stability and storage stability. Secondly, the DAG content can reach 36.

Abstract: Provided is an antibody-drug conjugate (ADC) using one or more cysteine or derivatives thereof as linkers to couple one or more drugs at the limited binding sites of an antibody, making it possible to produce an ADC product with high drug payload, or to choose a drug with less toxicity, thereby obtaining an ADC product with wide therapeutic window. In addition, since a plurality of drugs may be coupled to one binding site, the ADC products obtained by the method of the present disclosure have better uniformity in the case of same DAR value. Moreover, the amount of antibody required for production may be greatly reduced, thereby lowering the cost. Compared with the antibody-drug conjugates coupled only one drug, the antibody-drug conjugates produced by the method of the present disclosure have the same inhibition or killing effect on tumor cells while using fewer drugs for coupling to the same site.

Abstract: Display apparatuses and self-capacitance touch panels thereof are provided. A self-capacitance touch panel includes a touch wiring layer and a signal transmission wiring layer. The touch wiring layer includes a plurality of touch units arranged in an array, each of which includes a plurality of touch lines electrically connected. The signal transmission wiring layer includes a plurality of signal transmission lines extending in a row direction or a column direction, at least one of which is electrically connected with a corresponding one of the touch units and electrically insulated from the rest of the touch units in an extending direction thereof. At least a portion of an orthographic projection of the signal transmission line in a plane where the self-capacitance touch panel is located is misaligned with an orthographic projection of each of the touch lines of the touch units electrically insulated from the signal transmission line in the plane.

Abstract: A display panel and a display device are provided. The display panel comprises an encapsulation layer and a touch control structure on the encapsulation layer. The encapsulation layer comprises a plurality of pixel opening portions and spacing portions between the pixel opening portions. The touch control structure comprises a first conductive film layer, a second conductive film layer and an insulating layer between the first conductive film layer and the second conductive film layer, wherein the first conductive film layer comprises a plurality of touch control blocks, and the second conductive film layer comprises a plurality of touch control lines and a plurality of dummy lines. At least one dummy line is between adjacent touch control lines of at least some touch control lines. Each touch control block is electrically connected to one of the touch control lines via a conductive element arranged in the insulating layer.

Abstract: The present disclosure provides an electromagnetic shielding film, a flexible circuit board and a display device. The electromagnetic shielding film includes a central portion and an edge portion. The central portion has a plurality of surrounding side edges; and the edge portion is provided on at least one side edge of the central portion, and includes a plurality of protruding units protruding away from the central portion. The plurality of protruding units are arranged in an extending direction of the side edge where the edge portion is located. The electromagnetic shielding film is used to attach on a flexible circuit board body, the central portion is located on a non-bending area, and the edge portion is located on a bending area, so that the flexible circuit board is formed.

Abstract: The present application provides a touch panel, a display panel and a display device. The touch panel includes: a base substrate; a first conductive structure on the base substrate; and a dielectric structure on the first conductive structure. The first conductive structure includes: a first electrode structure and a second electrode structure that are spaced apart from each other. A projection of the dielectric structure to the base substrate overlaps at least a part of a projection of the first electrode structure and the second electrode structure to the base substrate.

Abstract: A display panel and a display device are provided. The display panel comprises an encapsulation layer and a touch control structure on the encapsulation layer. The encapsulation layer comprises a plurality of pixel opening portions and spacing portions between the pixel opening portions. The touch control structure comprises a first conductive film layer, a second conductive film layer and an insulating layer between the first conductive film layer and the second conductive film layer, wherein the first conductive film layer comprises a plurality of touch control blocks, and the second conductive film layer comprises a plurality of touch control lines and a plurality of dummy lines. At least one dummy line is between adjacent touch control lines of at least some touch control lines. Each touch control block is electrically connected to one of the touch control lines via a conductive element arranged in the insulating layer.

Abstract: The present application provides a touch panel, a display panel and a display device. The touch panel includes: a base substrate; a first conductive structure on the base substrate; and a dielectric structure on the first conductive structure. The first conductive structure includes: a first electrode structure and a second electrode structure that are spaced apart from each other. A projection of the dielectric structure to the base substrate overlaps at least a part of a projection of the first electrode structure and the second electrode structure to the base substrate.

Abstract: A display device, a touch panel and a method for manufacturing the touch panel. The touch panel of the present disclosure includes a substrate, a plurality of first touch electrodes, and a plurality of second touch electrodes. The first touch electrodes are arranged on the substrate. The second touch electrodes are arranged in the same layer as the first touch electrodes. Each of the second touch electrodes is formed by connecting in series a plurality of sub-electrodes insulated from the first touch electrodes, and two adjacent sub-electrodes in the same second touch electrode are respectively positioned on two sides of one of the first touch electrodes.

Abstract: Display apparatuses and self-capacitance touch panels thereof are provided. A self-capacitance touch panel includes a touch wiring layer and a signal transmission wiring layer. The touch wiring layer includes a plurality of touch units arranged in an array, each of which includes a plurality of touch lines electrically connected. The signal transmission wiring layer includes a plurality of signal transmission lines extending in a row direction or a column direction, at least one of which is electrically connected with a corresponding one of the touch units and electrically insulated from the rest of the touch units in an extending direction thereof. At least a portion of an orthographic projection of the signal transmission line in a plane where the self-capacitance touch panel is located is misaligned with an orthographic projection of each of the touch lines of the touch units electrically insulated from the signal transmission line in the plane.

Abstract: The present disclosure provides a flexible display screen and a display device. The flexible display screen includes: a substrate; a backing film stacked on a side of the substrate facing away from a light-emitting surface of the flexible display screen; and a pressure sensor stacked on a side of the backing film facing away from the substrate and configured to output a signal related to a force applied on the flexible display screen.

Abstract: The disclosure provides an ocular drug delivery system that includes a contact lens and a drug delivery portion, which may include a compound having the formula X—(CH2)n-Z, wherein X is a photocrosslinkable group. Advantageously, the drug delivery portion may aid in loading a high concentration of a negatively-charged therapeutic agent into the ocular drug delivery system. Additionally, the disclosed ocular drug delivery system may aid in controlled delivery of the negatively-charged therapeutic agent to the eye of a patient over a period of about 4 to about 24 hours.