Abstract: Provided is an anti-HER3 humanized monoclonal antibody. The antibody binds HER3 antigen, has high affinity and biological activity and low immunogenicity, and is stable in structure. The antibody can be used for preparing drugs for preventing or treating HER3-related diseases.

Abstract: The disclosure relates to KRASG12D inhibitor compounds having the structure of Formula (A) or Formula (B), pharmaceutical compositions thereof, and methods of use thereof for inhibiting, treating, and/or preventing KRASG12D mutation-associated diseases, disorders and conditions.

Abstract: An enzyme synthesizes hydroxyl acetaldehyde and/or 1,3-dihydroxyacetone by catalyzing formaldehyde. Site-directed mutation of benzoylformate decarboxylase (BFD) creates a mutant of the enzyme, which can polymerize the formaldehyde, A phosphoketalose (F/XPK) generates acetyl phosphoric acid from the hydroxyl acetaldehyde or 1,3-dihydroxyacetone (DHA). Combination with phosphotransacetylase (Pta) provides a route from the formaldehyde to acetyl coenzyme A in three steps.

Abstract: A data transmission method and an apparatus used in a virtual switch technology are provided, and the method includes: receiving an IO request of a virtual machine VM for accessing a file or a disk, and When the IO request is to be sent to a physical NIC by using a user mode Open vSwitch (OVS), converting the IO request into an Internet Small Computer Systems Interface (iSCSI) command in a user mode, and then sending the iSCSI command to the user mode OVS, where the user mode OVS sends the iSCSI command to the physical NIC.

Abstract: A virtualized cache implementation solution, where a memory of a virtual machine stores cache metadata. The cache metadata includes a one-to-one mapping relationship between virtual addresses and first physical addresses. After an operation request that is delivered by the virtual machine and that includes a first virtual address is obtained, when the cache metadata includes a target first physical address corresponding to the first virtual address, a target second physical address corresponding to the target first physical address is searched for based on preconfigured correspondences between the first physical addresses and second physical addresses, and data is read or written from or to a location indicated by the target second physical address.

Abstract: A data transmission method and an apparatus used in a virtual switch technology are provided, and the method includes: receiving an IO request of a virtual machine VM for accessing a file or a disk, and When the IO request is to be sent to a physical NIC by using a user mode Open vSwitch (OVS), converting the IO request into an Internet Small Computer Systems Interface (iSCSI) command in a user mode, and then sending the iSCSI command to the user mode OVS, where the user mode OVS sends the iSCSI command to the physical NIC.

Abstract: A data transmission method and an apparatus used in a virtual switch technology are provided. An IO request of a virtual machine VM for accessing a file or a disk is received. When the IO request is to be sent to a physical NIC by using a user mode Open vSwitch (OVS), the IO request is converted into an Internet Small Computer Systems Interface (iSCSI) command in a user mode The iSCSI command is then sent to the user mode OVS. The user mode OVS sends the iSCSI command to the physical NIC.

Abstract: A virtualized cache implementation solution, where a memory of a virtual machine stores cache metadata. The cache metadata includes a one-to-one mapping relationship between virtual addresses and first physical addresses. After an operation request that is delivered by the virtual machine and that includes a first virtual address is obtained, when the cache metadata includes a target first physical address corresponding to the first virtual address, a target second physical address corresponding to the target first physical address is searched for based on preconfigured correspondences between the first physical addresses and second physical addresses, and data is read or written from or to a location indicated by the target second physical address.

Abstract: A method and an apparatus for processing a read/write request in a physical machine, where the method includes polling, by a host by accessing memory of at least one of virtual storage devices, at least one instruction transmit queue of the at least one virtual storage device in order to obtain a first read/write request from the at least one instruction transmit queue, performing a first forwarding operation on the first read/write request, and obtaining, by the host, another first read/write request from the at least one instruction transmit queue by polling such that the host performs the first forwarding operation on the other first read/write request. According to the method and the apparatus in embodiments of the present disclosure, a speed of processing a read/write request in a virtualization storage scenario can be increased.

Abstract: An enzyme synthesizes hydroxyl acetaldehyde and/or 1,3-dihydroxyacetone by catalyzing formaldehyde. Site-directed mutation of benzoylformate decarboxylase (BFD) creates a mutant of the enzyme, which can polymerize the formaldehyde, A phosphoketalose (F/XPK) generates acetyl phosphoric acid from the hydroxyl acetaldehyde or 1,3-dihydroxyacetone (DHA). Combination with phosphotransacetylase (Pta) provides a route from the formaldehyde to acetyl coenzyme A in three steps.

Abstract: A data transmission method and an apparatus used in a virtual switch technology are provided. An IO request of a virtual machine VM for accessing a file or a disk is received. When the IO request is to be sent to a physical NIC by using a user mode Open vSwitch (OVS), the IO request is converted into an Internet Small Computer Systems Interface (iSCSI) command in a user mode The iSCSI command is then sent to the user mode OVS. The user mode OVS sends the iSCSI command to the physical NIC.

Abstract: A method and an apparatus for processing a read/write request in a physical machine, where the method includes polling, by a host by accessing memory of at least one of virtual storage devices, at least one instruction transmit queue of the at least one virtual storage device in order to obtain a first read/write request from the at least one instruction transmit queue, performing a first forwarding operation on the first read/write request, and obtaining, by the host, another first read/write request from the at least one instruction transmit queue by polling such that the host performs the first forwarding operation on the other first read/write request. According to the method and the apparatus in embodiments of the present disclosure, a speed of processing a read/write request in a virtualization storage scenario can be increased.

Abstract: A method of inhibiting graft rejection includes isolating Hepatic Stellate Cells from a mammal liver, activating the isolated Hepatic Stellate Cells, and administering a combination of Hepatic Stellate cells and a graft to a mammal.

Abstract: A method of inhibiting graft rejection includes isolating Hepatic Stellate Cells from a mammal liver, activating the isolated Hepatic Stellate Cells, and administering a combination of Hepatic Stellate cells and a graft to a mammal.

Abstract: The present invention relates to tolerogenic mammalian dendritic cells (DCs) and methods for the production of the tolerogenic DCs. In addition, the present invention provides a method for enhancing tolerogenicity in a host comprising administering the tolerogenic mammalian DCs of the present invention to the host. The tolerogenic DCs of the present invention comprise an oligodeoxyribonucleotide (ODN) which has one or more NF-?B binding sites. The tolerogenic DCs of the present invention may further comprise a viral vector, and preferably an adenoviral vector, which does not affect the tolerogenicity of the tolerogenic DCs when present therein. Enhanced tolerogenicity in a host is useful for prolonging foreign graft survival and for treating inflammatory related diseases, such as autoimmune diseases.

Abstract: The present invention relates to tolerogenic dendritic cells (DCs) and methods for enriching for these cells in tissue preparations and using the cells for preventing or minimizing transplant rejection or for treating or preventing an autoimmune disease.

Abstract: The present invention relates to tolerogenic mammalian dendritic cells (DCs) and methods for the production of the tolerogenic DCs. In addition, the present invention provides a method for enhancing tolerogenicity in a host comprising administering the tolerogenic mammalian DCs of the present invention to the host. The tolerogenic DCs of the present invention comprise an oligodeoxyribonucleotide (ODN) which has one or more NF-&kgr;B binding sites. The tolerogenic DCs of the present invention may further comprise a viral vector, and preferably an adenoviral vector, which does not affect the tolerogenicity of the tolerogenic DCs when present therein. Enhanced tolerogenicity in a host is useful for prolonging foreign graft survival and for treating inflammatory related diseases, such as autoimmune diseases.