Patents by Inventor Lina M. Obeid

Lina M. Obeid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
    Patent number: 8093393
    Abstract: The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: January 10, 2012
    Assignee: MUSC Foundation for Research Development
    Inventors: Alicja Bielawska, Zdzislaw M. Szulc, Yusuf A. Hannun, Lina M. Obeid, Besim Ogretmen
  • Cationic Ceramides, And Analogs Thereof, And Their Use For Preventing Or Treating Cancer
    Publication number: 20110071099
    Abstract: The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.
    Type: Application
    Filed: October 31, 2005
    Publication date: March 24, 2011
    Inventors: Alicja Bielawska, Zdzislaw M. Szuic, Yusuf A. Hannun, Lina M. Obeid, Besim Ogretmen