Patents by Inventor Lina Setti

Lina Setti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tricyclic compounds as histone methyltransferase inhibitors
    Patent number: 11584734
    Abstract: The present disclosure provides tricyclic compounds of formula (I) that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: February 21, 2023
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Ming Yu, Zhe Li, Qing Xu, Calvin Yee, Lina Setti, Hing Sham
  • TRICYCLIC COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS
    Publication number: 20200361896
    Abstract: The present disclosure provides tricyclic compounds of formula (I) that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
    Type: Application
    Filed: August 13, 2018
    Publication date: November 19, 2020
    Inventors: Ming YU, Zhe LI, Qing XU, Calvin YEE, Lina SETTI, Hing SHAM
  • Bridged bicyclic kallikrein inhibitors
    Patent number: 9815853
    Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: November 14, 2017
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Manuel Zancanella, Chul Yu, Lina Setti, Hing Sham, Qing Xu, Calvin Yee, Ming Yu
  • Pyrazolopyridine pyrazolopyrimidine and related compounds
    Patent number: 9695166
    Abstract: In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: July 4, 2017
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Qing Xu, Chul Yu, Calvin Yee, Stephen L. Gwaltney, II, Brian W. Metcalf, Steven Richards, Matthew A. Lardy, Lina Setti, Hing Sham
  • Biaryl amide compounds as kinase inhibitors
    Patent number: 9694016
    Abstract: The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 4, 2017
    Assignee: NOVARTIS AG
    Inventors: Robert John Aversa, Paul Andrew Barsanti, Matthew Burger, Michael Patrick Dillon, Alan Dipesa, Cheng Hu, Yan Lou, Gisele Nishiguchi, Yue Pan, Valery Polyakov, Savithri Ramurthy, Alice Rico, Lina Setti, Aaron Smith, Sharadha Subramanian, Benjamin Taft, Huw Tanner, Lifeng Wan, Naeem Yusuff
  • BRIDGED BICYCLIC KALLIKREIN INHIBITORS
    Publication number: 20160362427
    Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
    Type: Application
    Filed: June 9, 2016
    Publication date: December 15, 2016
    Inventors: Zhe Li, Manuel Zancanella, Chul Yu, Lina Setti, Hing Sham, Qing Xu, Calvin Yee, Ming Yu
  • BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS
    Publication number: 20160038504
    Abstract: The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
    Type: Application
    Filed: March 13, 2014
    Publication date: February 11, 2016
    Applicant: NOVARTIS AG
    Inventors: Robert AVERSA, Paul A. BARSANTI, Matthew BURGER, Michael Patrick DILLON, Alan DIPESA, Cheng HU, Yan LOU, Gisele NISHIGUCHI, Yue PAN, Valery POLYAKOV, Savithri RAMURTHY, Alice RICO, Lina SETTI, Aaron SMITH, Sharadha SUBRAMANIAN, Benjamin TAFT, Huw TANNER, Lifeng WAN, Naeem YUSUFF
  • Biaryl amide compounds as kinase inhibitors
    Patent number: 9242969
    Abstract: The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: January 26, 2016
    Assignee: Novartis AG
    Inventors: Paul A. Barsanti, Matthew Burger, Yan Lou, Gisele Nishiguchi, Valery Polyakov, Savithri Ramurthy, Alice Rico, Lina Setti, Aaron Smith, Benjamin Taft, Huw Tanner, Alan DiPesa, Naeem Yusuff
  • PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS
    Publication number: 20150315198
    Abstract: In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.
    Type: Application
    Filed: May 4, 2015
    Publication date: November 5, 2015
    Applicant: Global Blood Therapeutics, Inc.
    Inventors: Zhe Li, Qing Xu, Chul Yu, Calvin Yee, Stephen L. Gwaltney,, II, Brian W. Metcalf, Steven Richards, Matthew A. Lardy, Lina Setti, Hing Sham
  • BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS
    Publication number: 20140275003
    Abstract: The present invention provides compounds of Formula (I) as described herein, and salts thereof, and therapeutic uses of these compounds for treatment of disorders associated with Raf kinase activity. The invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds and a therapeutic co-agent.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: NOVARTIS AG
    Inventors: Paul A. Barsanti, Matthew Burger, Yan Lou, Gisele Nishiguchi, Valery Polyakov, Savithri Ramurthy, Alice Rico, Lina Setti, Aaron Smith, Benjamin Taft, Huw Tanner, Alan DiPesa, Naeem Yusuff