Abstract: The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of mustards and mustard-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

Abstract: In some examples, a user equipment may perform a method that includes identifying that a first wireless network operated by an enterprise is accessible to the user equipment as well as identifying that a second wireless network different from the first wireless network and also operated by the enterprise is accessible to the user equipment. The method performed by the user equipment may further include selecting the first wireless network to connect to instead of the second wireless network based on an enterprise employee characteristic associated with the user equipment.

Abstract: A method for configuring a Near Field Communication (NFC) smart card, includes: receiving a card selected by a user, the card being included in a card set corresponding to the user; determining at least one card which has no conflict with the selected card in the card set; adding the at least one card and the selected card in the NFC smart card, wherein each card in the NFC smart card is in an activated state.

Abstract: The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for 4-aminophenol derivatives, which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes.

Abstract: One aspect of the invention provides a composition of novel high penetration compositions (HPC) or a high penetration prodrug (HPP) for treatment of Parkinson's disease. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

Abstract: Provided are a high-affinity full human monoclonal antibody highly specifically targeting to TIM-3 and a preparation method therefor. The monoclonal antibody has a remarkable antitumor activity, and can be used for preparing a related diagnostic reagent or a pharmaceutical composition preventing or treating diseases related to TIM-3 dysfunction.

Abstract: Disclosed is a pesticide composition for controlling Spodoptera frugiperda. The pesticide includes an auxiliary material, an active ingredient A and an active ingredient B. The active ingredient A is tea saponin, the active ingredient B is chlorantraniliprole or tolfenpyrad, and the mass ratio of the active ingredient A to the active ingredient B is 1-20:20-1. In the present invention, by mixing tea saponin with chlorantraniliprole or tolfenpyrad, a pesticide with certain ratio is prepared to control Spodoptera frugiperda, has the advantages of good effect and low dosage, and can delay the resistance of Spodoptera frugiperda to pesticides.

Abstract: The present disclosure provides a method and device for switching an NFC card. The method can include determining a non-smart NFC card from a card set that includes smart NFC cards that are activated by default. The method can further include performing an activation operation on the non-smart NFC card, and calling the non-smart NFC card on which the activation operation has been completed to perform near-field communication interaction with a card reading device in a case of receiving response information of activation success, where the response information of activation success indicates that the non-smart NFC card and the smart NFC cards do not conflict. Through the technical solution of the present disclosure, the near-field communication interaction efficiency based on the NFC card can be improved.

Abstract: The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for non-steroidal anti-inflammatory agents (NSAIAs), which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes.

Abstract: Disclosed by the present invention are an antibody targeting CTLA-4, a preparation method therefor and a use thereof. In particular, disclosed by the present invention is a novel fully human monoclonal antibody that targets CTLA-4. Further disclosed by the present invention is a method for preparing the monoclonal antibody. The monoclonal antibody of the present invention is capable of binding a CTLA-4 antigen with high specificity, has a high affinity, remarkable anti-tumor activity, and so on.

Abstract: The present invention relates to compositions and uses of novel high penetration compositions or high penetration prodrugs (HPP), in particular HPPs for 4-aminophenol derivatives, which are capable of crossing biological barriers with high penetration efficiency. The HPPs herein are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, due to the ability of penetrating biological barriers, the HPPs herein are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs herein can be administered to a subject through various administration routes.

Abstract: A method includes receiving information that defines a three-dimensional subterranean structure; splitting the three-dimensional subterranean structure into portions; generating convex hulls for the portions; and generating a discrete fracture network based at least in part on the convex hulls.

Abstract: A preprocessing method for configuring a near field communication (NFC) smart card, includes: determining a card set belonging to a user; generating identifier information corresponding to the card set according to a non-contact parameter corresponding to a card included in the card set, the identifier information identifying at least one of a state of conflict or a state of compatibility between two cards included in the card set; and sending the identifier information to electronic equipment used by the user, such that the electronic equipment adds, to an NFC smart card according to the identifier information, at least two cards compatible with each other in the card set.

Abstract: One aspect of the invention provides a composition of novel high penetration compositions (HPC) or a high penetration prodrug (HPP) for treatment of Parkinson's disease. The HPCs/HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPCs/HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

Abstract: In some examples, a user equipment may perform a method that includes identifying that a first wireless network operated by an enterprise is accessible to the user equipment as well as identifying that a second wireless network different from the first wireless network and also operated by the enterprise is accessible to the user equipment. The method performed by the user equipment may further include selecting the first wireless network to connect to instead of the second wireless network based on an enterprise employee characteristic associated with the user equipment.

Abstract: Disclosed in the present invention are an antibody targeting LAG-3, a preparation method therefor and the use thereof. In particular, disclosed in the present invention is a novel monoclonal antibody targeting LAG-3. Also disclosed in the present invention is a method for the preparation of the monoclonal antibody. The monoclonal antibody of the present invention is capable of binding LAG-3 antigens with high specificity, and has very high affinity and significant activities such as anti-tumor activity.

Abstract: A preprocessing method for configuring a near field communication (NFC) smart card, includes: determining a card set belonging to a user; generating identifier information corresponding to the card set according to a non-contact parameter corresponding to a card included in the card set, the identifier information identifying at least one of a state of conflict or a state of compatibility between two cards included in the card set; and sending the identifier information to electronic equipment used by the user, such that the electronic equipment adds, to an NFC smart card according to the identifier information, at least two cards compatible with each other in the card set.

Abstract: A method for configuring a Near Field Communication (NFC) smart card, includes: receiving a card selected by a user, the card being included in a card set corresponding to the user; determining at least one card which has no conflict with the selected card in the card set; adding the at least one card and the selected card in the NFC smart card, wherein each card in the NFC smart card is in an activated state.

Abstract: The present disclosure provides a method and device for switching an NFC card. The method can include determining a non-smart NFC card from a card set that includes smart NFC cards that are activated by default. The method can further include performing an activation operation on the non-smart NFC card, and calling the non-smart NFC card on which the activation operation has been completed to perform near-field communication interaction with a card reading device in a case of receiving response information of activation success, where the response information of activation success indicates that the non-smart NFC card and the smart NFC cards do not conflict. Through the technical solution of the present disclosure, the near-field communication interaction efficiency based on the NFC card can be improved.

Abstract: The present invention provides an anti-C5aR antibody and a preparation method and use thereof. The anti-C5aR antibody comprises one or more of the followings: a heavy chain CDR1, heavy chain CDR2 or heavy chain CDR3 of a heavy chain variable region of an anti-C5aR antibody, and one or more of the followings: a light chain CDR1, light chain CDR2 or light chain CDR3 of a light chain variable region of the anti-C5aR antibody. The anti-C5aR antibody has a high affinity to human C5aR protein and can block the binding of the C5aR protein to a C5a, thus downregulating or switching off a corresponding signaling pathway, stopping C5a directed migration of a neutrophil in vitro and inhibiting chemotaxis of the neutrophil.