Abstract: The present invention discloses a multi-channel impact-resistant intelligent-constant-deceleration hydraulic braking system, and relates to the field of safety braking control for mine hoist systems. A technical point of the braking system is that the braking system includes a braking circuit formed by a constant-deceleration hydraulic system, a constant-deceleration electrical closed-loop control system, and a detection and feedback apparatus. The constant-deceleration hydraulic system is provided with N+1 independent complete oil return channels, where N is a positive integer greater than or equal to 3. The oil return channels are disposed in parallel to form parallel independent braking circuits, that is, are “multi-channel” and do not have a “common output point”. The oil return channel includes a backup oil source, an electro-hydraulic signal conversion and amplification component, an operating mode switching apparatus, and an execution component that are sequentially connected.

Abstract: A JAK inhibitor may be used in preparation of a medicament. The medicament may be used for preventing and/or treating a disease or condition associated with an antitumor agent in a subject. A pharmaceutical composition may include the JAK inhibitor as may a kit. The JAK inhibitor may include a compound of formula (I) or a pharmaceutically acceptable salt thereof: Q, X, Y, and Z being independently N or C, and R1, R2 and R3 being independently a 5-6-membered aromatic ring, 5-6-membered heteroaromatic ring, 5-6-membered cycloalkyl, 5-6-membered heterocycloalkyl, amino, or amido, the aromatic ring, heteroaromatic ring, cycloalkyl, and/or heterocycloalkyl being optionally substituted by a substituent.

Abstract: The present invention relates to methods and compositions for assessing copy number of a target polynucleotide in a sample, methods and compositions for establishing a standard curve for a target polynucleotide, and the uses of the methods and compositions for detecting a pathogen, e.g., human papillomavirus (HPV).

Abstract: The present invention relates to methods and compositions, and uses thereof, for simultaneously detecting expression of multiple target genes in a sample. The present invention further relates to certain isolated polynucleotides that can be used as primers or primer pairs in the present methods and compositions for simultaneously detecting expression of multiple target genes in a sample.

Abstract: The present invention provides methods and compositions, and uses thereof, for simultaneously detecting one target SNP locus or multiple target SNP loci in a sample. In exemplary embodiments, the present invention also provides a multiplex SNP assay technique, which can simultaneously detect up to 20 SNP loci (40 alleles) with high level of specificity (e.g., >99.9%), sensitivity (e.g. 100%) and accuracy, high throughput, cost-effective and time-saving, reduced or no false-negative results. The present invention further provides certain isolated polynucleotides that can be used as primers or primer pairs in the present methods and composition for simultaneously detecting one target SNP locus or multiple target SNP loci in a sample.

Abstract: The present invention relates to methods and compositions for assessing copy number of a target polynucleotide in a sample, methods and compositions for establishing a standard curve for a target polynucleotide, and the uses of the methods and compositions for detecting a pathogen, e.g., human papillomavirus (HPV).